I-Decitabine CAS 2353-33-5 Purity >99.5% (HPLC) Factory
I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi oholayo nomphakeli we-Decitabine (CAS: 2353-33-5) enekhwalithi ephezulu.Singahlinzeka nge-COA, ukulethwa komhlaba wonke, amanani amancane kanye nenqwaba etholakalayo.Uma unentshisekelo kulo mkhiqizo, sicela uthumele imininingwane enemininingwane ehlanganisa inombolo ye-CAS, igama lomkhiqizo, nenani kithi.Please contact: alvin@ruifuchem.com
| Igama Lekhemikhali | I-Decitabine |
| Omqondofana | 5-Aza-2'-Deoxycytidine;5-Aza-1-(2-Deoxy-β-D-Ribofuranosyl)cytosine;5-Aza-CdR;5-Aza-dC;5-Deoxy-2'-Azacytidine;I-ZdCyd;I-DAC;β-Decitabine |
| Inombolo ye-CAS | 2353-33-5 |
| Inombolo yeCAT | RF2728 |
| Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani |
| I-Molecular Formula | I-C8H12N4O4 |
| Isisindo samangqamuzana | 228.21 |
| I-Melting Point | 191℃(dec.) |
| Kuyazwela | Izwela Umoya, Izwela Ukushisa |
| Ukuncibilika | Ihlakazwe ku-DMSO;Incibilika Kancane Emanzini |
| Ibhrendi | I-Ruifu Chemical |
| Into | Imininingwane |
| Ukubukeka | I-Crystalline Powder Emhlophe noma Engamhlophe |
| Ukuhlonza A | IR: Isampula ye-IR Spectrum Ihambisana Naleyo Yezinga |
| Ukuhlonza B | I-HPLC: I-RT ye-Major Peak Yesixazululo Sokuhlola Ihambisana naleyo Yesixazululo Esijwayelekile |
| Ukuhlonza C | I-PXRD: Kuhle |
| Ukuhlanzeka / Indlela Yokuhlaziya | >99.5% (HPLC) |
| I-Alpha | +56.0°~ 63.0° |
| Ukulahlekelwa Ekumisweni | <0.50% |
| Izinsalela ekushiseni | <0.10% |
| Izinsimbi Ezisindayo | <20ppm |
| Izinto Ezihlobene | |
| I-α-Decitabine | <0.20% |
| Ukungcola Okungaziwa Okukodwa | <0.20% |
| Ukungcola Okuphelele | <0.50% |
| Izincibilikisi Ezisele | |
| I-DMSO | <0.50% |
| I-Methanol | <0.30% |
| I-Methyl Formate | <0.05% |
| I-acetonitrile | <0.041% |
| Ukuncibilika | I-Colorless Clear 50 mg/ml, i-HOAc ne-H2O (1:1) Dlula |
| Izinga Lokuhlola | I-Enterprise Standard |
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwemfuneko yekhasimende
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni nakumswakama
Indlela Yokuthenga?Please contact: sales@ruifuchem.com or alvin@ruifuchem.com
Iminyaka engu-15 Yokuhlangenwe nakho?Sinesipiliyoni seminyaka engaphezu kwe-15 ekwakhiweni nasekuthumeleni kwamanye amazwe uhla olubanzi lwezinga eliphezulu lokuxhumanisa imithi noma amakhemikhali amahle.
Izimakethe Eziyinhloko?Thengisa emakethe yasekhaya, eNyakatho Melika, eYurophu, eNdiya, eRussia, eKorea, eJapane, e-Australia, njll.
Izinzuzo?Ikhwalithi ephezulu, intengo ethengekayo, izinsizakalo ezichwepheshile nokusekelwa kobuchwepheshe, ukulethwa okusheshayo.
IkhwalithiIsiqiniseko?Isistimu yokulawula ikhwalithi eqinile.Imishini yobuchwepheshe yokuhlaziya ifaka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, NOMA, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njll.
Amasampula?Imikhiqizo eminingi inikeza amasampula wamahhala wokuhlolwa kwekhwalithi, izindleko zokuthumela kufanele zikhokhelwe amakhasimende.
Ukuhlolwa Kwemboni?Wamukelekile ekucwaningweni kwemboni.Sicela wenze i-aphoyintimenti kusengaphambili.
I-MOQ?Ayikho i-MOQ.I-oda elincane liyamukeleka.
Isikhathi sokuthumela? Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe.
Ezokuthutha?By Express (FedEx, DHL), by Air, by Sea.
Amadokhumenti?Ngemuva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njll.
Custom Synthesis?Ingahlinzeka ngezinsizakalo zokwenziwa ngokwezifiso ukuze zilingane kangcono nezidingo zakho zocwaningo.
Imigomo Yokukhokha?I-invoyisi ye-Proforma izothunyelwa kuqala ngemva kokuqinisekiswa kwe-oda, kufakwe nemininingwane yethu yasebhange.Inkokhelo nge-T/T (Telex Transfer), PayPal, Western Union, njll.
I-Decitabine (CAS: 2353-33-5) (igama lokuhweba i-Dacogen), noma i-5-Aza-2'-Deoxycytidine.Ngamakhemikhali, i-analog ye-cytidine.I-Decitabine iyi-ejenti ye-hypomethylating.I-Decitabine yethulwe ukwelashwa kwe-myelodysplastic syndromes (MDS).I-MDS iqoqo lezinkinga ze-hematological ezithinta umnkantsha oholela ekwakhekeni okungasebenzi kahle nokuthuthukiswa kwamangqamuzana egazi.Ngaphezu kwalokho, iziguli ezine-MDS zisengozini enkulu yokuthuthukela ku-acute myeloid leukemia (AML).Ukwelapha okuvamile kuhlanganisa ukumpontshelwa igazi, izici zokukhula kwe-hematopoietic, kanye nama-antibiotic e-prophylactic, kodwa lezi zinyathelo zithuthukisa izinga lempilo ngemiphumela engabazekayo ekuguqulweni kwezifo.Nakuba ukufakelwa kwe-stem-cell kuyindlela enolaka, engase yelaphe, iminyaka yobudala noma ezinye izinkinga zezempilo eziyinkimbinkimbi zeziguli eziningi zibavimbela ekucabangeni le nketho.Intuthuko yakamuva ku-etiology eyisisekelo ye-MDS, nokho, iholele ekwakhiweni kwesigaba esisha sezinhlanganisela ezaziwa ngokuthi ''i-demethylating agents''.I-Decitabine ilandela ukwethulwa ngempumelelo kwe-DNA methyltransferase inhibitor yokuqala i-Azacitidine.I-hypomethylates i-DNA ngokuvimbela i-DNA methyltransferase.Isebenza ngendlela efanayo ne-Azacitidine, nakuba i-decitabine ingafakwa kuphela emicu ye-DNA kuyilapho i-azacitidine ingafakwa kuwo womabili amaketanga e-DNA ne-RNA.Ama-reagents ocwaningo: I-Decitabine isetshenziswa kabanzi kubhayoloji yamangqamuzana, i-pharmacology, nolunye ucwaningo lwesayensi.I-Decitabine njenge-DNA methyltransferase inhibitor ethile, inqubo ye-DNA methylation ehlehliswayo, yenza amaseli wesimila kumaseli avamile ukuze ahlukanise noma enze i-tumor cell apoptosis.Sicela wazi ukuthi ukugxila okuphezulu kwe-Decitabine kungadlala umphumela wayo we-cytotoxic: kungavimbela ukuhlanganiswa kwe-DNA okubangelwa ukufa kweseli.
