I-Desmopressin Acetate CAS 16789-98-3 Peptide Purity (HPLC) ≥98.5% Factory

Izimpawu Zengozi Xn - Ziyingozi
Amakhodi Engozi 20 - Ayingozi ngokuhogela
Incazelo Yezokuphepha 36 - Gqoka izingubo ezifanele zokuzivikela.
I-WGK Germany 3

I-Desmopressin Acetate (CAS: 16789-98-3) okungukuthi, i-1-cysteine ​​deamination kanye ne-8-D-arginine esikhundleni se-8-l-arginine, eyaziwa nangokuthi i-arginine vasopressin, iyi-analog yesakhiwo se-arginine vasopressin yemvelo, okuphuma kuyo. i-vasopressin, umphumela wayo we-antidiuretic unamandla futhi uhlala isikhathi eside kune-vasopressin, kodwa awukho umphumela we-vasoconstrictor, imiphumela emibi yezidakamizwa, umtholampilo wokungasebenzi kahle kweplatelet yokuzalwa noma yezidakamizwa, i-uremia, i-cirrhosis yesibindi kanye nezimbangela ezingaziwa ezibangelwa isikhathi sokopha isikhathi eside;Ingasetshenziselwa ukulawula nokuvimbela ukopha ngesikhathi sokuhlinzwa okuncane;Isifo sikashukela i-insipidus.Ezimweni ezingazodwana, lo mkhiqizo uzokhiqiza ukusebenza kahle ezigulini ezinezifo zesistimu yomchamo ophakathi, evame ukukhutshazwa ezigulini ezine-Type IIB von Willebrand isifo.
Isenzo se-Pharmacological: I-Desmopressin Acetate iqukethe i-desmopressin enesakhiwo esifana ne-arginine vasopressin yomdabu.Kungumehluko phakathi kwe-arginine vasopressin, ikakhulukazi engxenyeni ye-amino acid kanye ne-D arginine esikhundleni se-L Arginine.Lezi zinguquko zesakhiwo zandisa isikhathi sokusebenza somthamo womtholampilo we-desmopressin ngaphandle kwemiphumela emibi yokucindezelwa.Olunye ucwaningo luye lwabonisa ukuthi umphumela we-anti-enuresis ubalulekile, okungenzeka kube ngenxa yokwanda kwamazinga e-arginine vasopressin egazini lezingane ebusuku, bese ugxilisa umchamo, unciphise umthamo womchamo kanye nokucindezela kwe-intravascular, ukwehla kwentamo kanye ne-intravascular pressure. i-detrusor contraction.
Ukusebenza kwayo, ukuphatha kalula (intranasal), isikhathi eside sokusebenza, kanye nokuntuleka kwemiphumela emibi kwenza kube umuthi okhethwayo ekwelapheni isifo sikashukela esimaphakathi ne-insipidus.Ingase futhi inikezwe nge-intramuscularly ortravenously.Kukhethwa umjovo we-vasopressin kanye nama-antidiuretics ngomlomo ukuze asetshenziswe ezinganeni.Kuboniswa ekuphathweni kwe-polydipsia yesikhashana kanye ne-polyuria ehambisana nokuhlukumezeka, noma ukuhlinzwa endaweni ye-pituitary.
Ukusetshenziswa Komtholampilo: I-Desmopressin, njengosawoti wayo we-acetate, iyi-analogue yokwenziwa ye-vasopressin lapho i-N terminal Cys ingenawo umsebenzi wayo we-α-amino (1-Deamino) nalapho i-Arg8 ikhona njenge-D-isomer (D-Arg8) , ngaleyo ndlela isifinyezo sezohwebo i-DDAVP.Ukuba khona kwe-D-Arg kanye nokungabikho kwe-N-terminal amine esakhiweni se-desmopressin kukhulise isigamu sempilo yayo kangangokuthi itholakalela ukusetshenziswa ngomlomo, ngomzali, noma emakhaleni.Isetshenziswa yizo zontathu lezi zindlela zokuphatha ukuvimbela noma ukulawula i-polydipsia (ukoma ngokweqile), i-polyuria, nokuphelelwa amanzi emzimbeni kweziguli ezinesifo sikashukela i-insipidus okubangelwa ukuntuleka kwe-vasopressin.Iphinde yagunyazwa ukwelapha i-enuresis yasebusuku (ukumanzisa embhedeni), okukholakala ukuthi kubangelwa ukungabikho kokwenyuka kwesikhathi sasebusuku okujwayelekile kumazinga e-vasopressin.I-Desmopressin yaziwa ngokubangela ukwanda kokubili kwe-plasma factor VIII (antihemophilic factor) kanye ne-activator ye-plasminogen.Ngakho-ke kuvunywe yi-US FDA ukuthi isetshenziswe, ngokuzala namakhala, ekwehliseni iziqephu zokopha okuzenzakalelayo noma ezibangelwa ukuhlukumezeka ezigulini ezine-hemophilia A kanye nohlobo I-Von Willebrand's disease, inqobo nje uma umsebenzi wazo we-plasma factor VIII ungaphezu kuka-5%.I-Stimate, isifutho samakhala esisetshenziswa ekwelapheni iziguli ezine-hemophilia A kanye nohlobo I-Von Willebrand's disease, siphindwe izikhathi ezingu-15 ukugxila kwe-DDAVP nasal spray;Lesi sakamuva sisetshenziswa ekwelapheni isifo sikashukela i-insipidus.