I-Diethylphosphonoacetic Acid CAS 3095-95-2 Ukuhlanzeka >99.5% (HPLC) I-Afatinib Dimaleate Intermediate Factory

Incazelo emfushane:

Igama Lekhemikhali: I-Diethylphosphonoacetic Acid

I-CAS: 3095-95-2

Ubumsulwa: >99.5% (HPLC)

Ukubukeka: Uketshezi Olungenambala

I-Intermediate ye-Afatinib Dimaleate (CAS: 850140-73-7)

Ikhwalithi Ephezulu, Ukukhiqizwa Kwezohwebo

E-Mail: alvin@ruifuchem.com

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Imikhiqizo Ehlobene

Omaka bomkhiqizo

Incazelo:

I-Ruifu Chemical Supply Intermediates ye-Afatinib
I-Afatinib CAS 439081-18-2
I-Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(I-Dimethylamino)i-acetaldehyde I-Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
I-Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-one CAS 162012-69-3
I-7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineI-CAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineI-CAS 314771-88-5

Chemical Properties:

Igama Lekhemikhali	I-Diethylphosphonoacetic Acid
Omqondofana	2-(Diethoxyphosphoryl)i-acetic Acid;(Diethoxyphosphinyl)i-acetic Acid;I-Diethyl Carboxymethylphosphonate;I-NSC 272281
Inombolo ye-CAS	3095-95-2
Inombolo yeCAT	I-RF-PI2024
Isimo Sesitoko	Esitokweni, Amandla Okukhiqiza 30MT/Inyanga
I-Molecular Formula	(C2H5O)2P(O)CH2CO2H
Isisindo samangqamuzana	196.14
Iphuzu elibilayo	150℃/0.05 mmHg (lit.)
Ukuminyana	1.220 g/mL ku-25℃ (lit.)
I-Refractive Index	n20/D 1.445 (lit.)
Ibhrendi	I-Ruifu Chemical

Imininingwane:

Into	Imininingwane
Ukubukeka	Uketshezi Olungenambala
I-Identification (HPLC)	Isikhathi sokugcina sesilinganiso esiphezulu esitholwe kusampula singaphakathi kuka-5% wesampula yereferensi.
Ukuhlanzeka / Indlela Yokuhlaziya	>99.5% (HPLC)
I-Infrared Spectrum	Ivumelana Nesakhiwo
I-Proton NMR Spectrum	Ivumelana Nesakhiwo
Umswakama (KF)	<0.50%
Ukungcola Okuphelele	<0.50%
Izinga Lokuhlola	I-Enterprise Standard
Ukusetshenziswa	I-Intermediate ye-Afatinib Dimaleate (CAS: 850140-73-7)

Iphakheji nesitoreji:

Iphakheji: Ibhodlela eliFluorinated, 25kg/ Drum, noma ngokwezidingo zekhasimende

Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni nakumswakama

Izinzuzo:

I-FAQ:

Isicelo:

I-Diethylphosphonoacetic Acid (CAS: 3095-95-2), Isebenza njenge-nucleophile ye-nucleophilic add reactions for synthesis of allene epoxides I-Reactant for: Izifundo ze-Stereoselectivity zokusabela kwe-Staudinger;Ukwakheka kwe-enantioselective kwama-diols nge-epoxidation kanye nokusabela kwe-hydration;ukusabela kukaHorner-Wadsworth-Emmons;Ukuhlelwa kabusha kwe-Ireland-Claisen kulawulwa kude;Ukusabela kwe-Ugi-Dieckmann kokuhlanganiswa kwe-tetramic acid derivatives;Isetshenziselwa ukwenza i-phosphonoester intermediate yokusabela kwe-intramolecular HEW.I-Diethylphosphonoacetic Acid iphakathi kwe-Afatinib Dimaleate (CAS: 850140-73-7).U-Afatinib Dimaleate wagunyazwa yi-US Food and Drug Administration (FDA) ngo-2013 ukuze welaphe umdlavuza wamaphaphu ongewona omncane (NSCLC).Ngokukhethekile, kugunyazwe iziguli ezethula izimila ze-metastatic NSCLC eziqukethe ukususwa kwe-epidermal growth factor receptor (EGFR) noma ukuguqulwa kwe-exon 21.I-Afatinib Dimaleate iyi-covalent inhibitor ye-ErbB tyrosine kinases (tyk), eyehlisa ukusayinda kwe-ErbB ngokubophezela okungenakuhlehliswa kwamasayithi okubophezela kwe-EGFR tyk.