I-DMF-DMA CAS 4637-24-5 N,N-Dimethylformamide Dimethyl Acetal Purity >99.0% (GC) Ukudayiswa Okushisayo Kwefekthri

Njengoba u-Meenvin abike ngokulungiswa kwe-DMF-DMA (N,N-Dimethylformamide Dimethyl Acetal) ngo-1956, i-DMF-DMA isiphenduke i-reagent evame ukusetshenziswa ekuhlanganiseni kwezinto eziphilayo.
I-DMF-DMA isetshenziswa kabanzi ekwakhiweni kwamasongo e-heterocyclic anamalungu amahlanu noma ayisithupha ekuphenduleni kokuvalwa kwendandatho.I-DMF-DMA inokusabela okuthambile kanye nesivuno esikhulu, ikakhulukazi kumakhompiyutha aphezulu wokumelana.
Isakhiwo esijwayelekile sama-amide acetal compounds simi kanje:
Okusetshenziswa kakhulu i-DMF-DMA kanye ne-DMF-DEA, i-amide acetal i-hydrolyzed kalula, ingafakwa esterified, i-amidine, i-alkylation kanye nokusabela kwe-cyclization.
I-athomu ye-carbon emaphakathi ye-DMF-DMA ixhunywe nama-heteroatom amathathu ane-electronegative enkulu, okuyenza ibe nomsebenzi onamandla we-electrophilic.Ngaphansi kwesenzo se-asidi, iqembu le-alkoxy kulula ukulishiya, futhi ama-ion amahle anomsebenzi onamandla we-electrophilic ayatholakala.Ukusabela kwe-DMF-DMA ikakhulukazi kuqukethe ukusabela kwe-methylation kanye nokusabela kokwakheka.
"I-One-carbon Syntheson" ye-DMF-DMA
Ekuphenduleni kokuvalwa kweluphu okubandakanya i-DMF-DMA, i-athomu yekhabhoni eyodwa kuphela emkhiqizweni ivamise ukuhlinzekwa yi-DMF-DMA, ngakho-ke i-DMF-DMA ingathathwa njenge-carbon syntheson.
Ukusabela kwe-DMF-DMA esterification
I-DMF-DMA esterification inika amandla ama-acids e-carboxylic ahlukahlukene ukuthi akhiqize kalula i-C1-20 alkyl noma i-aryl esters, futhi imikhiqizo ekhiqizwayo ingahlukaniswa kalula ngokuhluzwa kwezinti.
I-adipic acid ne-DMF-DMA zafakwa esterified ku-80 degrees amahora amabili.I-Amide acetal iyinketho efanelekile yokufakwa kwe-esterification kwamanye ama-carboxylic acid anesithiyo esibulalayo noma ukuqina okungekuhle.
Ukusabela kwe-DMF-DMA amidination kanye nokuvikelwa kwama-amine ayinhloko
I-Amide acetals ayikwazi ukusabela kuphela ngama-amine ayinhloko, kodwa futhi nama-amides, ama-carbamates, ama-sulfonamides ukuze enze izibopho ze-hydrocarbon.
Okufana nokuthi: 2, 4-dimethyl aniline kanye ne-DMF-DMA kuma-degree angu-80 ingasusa ngokushesha i-methanol ukuze yenze izinhlanganisela ze-dimethamidine.
I-DMF-DMA ingasetshenziswa njengeqembu eliyinhloko lokuvikela i-amine, iqembu eliyinhloko lokuvikela i-amine (2 NH konke ukuvikela) cishe abantu abaningi bacabanga nge-phthalyl, i-pyrrole ring, i-Double Boc, i-PMB ephindwe kabili, njll., kodwa ukuvikelwa kwe-DMF-DMA kwesisekelo sokuqala. i-amine, kwezinye izimo futhi isikimu sokuvikela esiwusizo kakhulu, ukuvikela okuvaliwe kudinga kuphela i-TFA imiksi.
Ukuvikelwa kwe-amino - 13 isethulo esivamile sokuvikela, isipiliyoni sokukhetha isisekelo sokuvikela, ububanzi bokusetshenziswa, izimo zesingeniso, imibandela yokususa ukwabelana ngesifinyezo
I-DMF-DMA ihlangana namaqembu e-methyl ne-methylene asebenzayo ukwenza amabhondi e-carbon-carbon double
I-Phenylmethylation ye-DMF-DMA
Ukusabela kwe-Heterocyclic kwamakhemikhali ku-DMF-DMA
I-amide acetal njengomnikezeli wekhabhoni oyedwa ingasetshenziswa ukwenza izinhlanganisela ezihlukahlukene eziyinkimbinkimbi nezinto zemvelo ze-biomimetic.Nge-Acetals Acetals ingahletha: 1,2.4 Triazole, 1.2, 4 Triazolone, i-Aminoheterocyclic Derivatives, i-iSooxazole, i-Pyridine, iPyranenine, i-Pyrazine, iPyyrazine kanye nolunye uchungechunge ye-ammonia heterocyclic derivatives, ingabuye ihlanganiswe ne-oksijeni, i-sulphur heterocyclic compounds.
Ngokohlobo lokusabela kwamakhemikhali, ukusetshenziswa kwe-amide acetal ku-heterocyclic compound synthesis kungahlukaniswa kube yizici ezintathu ezilandelayo.
(1): i-amide acetal ne-amine, i-amide, i-carbamate lipid reaction, yenza izindandatho ezihlukahlukene ze-heterocyclic
Ukusabela kwe-amidoacetal kanye ne-amine ku-formamidine emaphakathi, bese kuba yindandatho ye-intramolecular nucleophilic ukukhiqiza ama-heterocycle ahlukahlukene, noma i-formamidine ne-hydrazine, i-hydroxylamine, i-l, i-2, i-alkyl halide eyodwa noma amabili aqukethe amaqembu amabili asebenzayo wezinhlanganisela kanye neketango elide lekhabhoni, bese kuba indandatho ye-intramolecular. .
Ukuhlanganiswa kwe-heterocyclic compounds ngokusabela kwe-amide acetals nama-amides, njengokuhlanganiswa kwe-l, i-2,4 monotriazole derivatives.Okokuqala, i-acetal ihlangana ne-amide yakhe i-N, N 'tritradil, bese ikhala nge-phenylhydrazine ukuze yakhe u-l, okuphuma ku-2,4 monotriazole.
I-amide acetals isabela nge-carbamic acid noma i-acetate ukwenza izindandatho ze-heterocyclic ezine-chlorine.I-diactive intermediate eyakhiwe ukusabela kwe-amide acetal ene-aminoethyl ester: i-nn-dimethyl-n 'alkyl-carboxymethyl formamidine, esabela nge-hydrazine noma i-hydrazine esikhundleni.Isibonelo, ukulungiselela i-1,2,4 triazinone-6, i-equation iboniswe ngezansi.Uma usabela nge-nitro-formate uthola i-1,2,4 triazolone-5.
Indlela yokusabela yokwakheka kwe-1,2,4 triazolone-5
Ukwakheka kwe-1.2.4-triazolidin-5 kuyizinyathelo ezimbili.Okokuqala, i-ethyl carbamate kanye ne-DMF diformaldehyde acetals zakha i-Nn-dimethyl-n-ethoxy-formamidine ephakathi.Okwesibili, iqembu le-amino ku-phenylhydrazine livimbela ikhabhoni ku-formamidine, elahlekelwa -N (CH3).Bese i-ammonia eseringini ye-benzene eduze ne-phenylhydrazine ihlasela ikhabhoni eseqenjini lekhabhoni, yakhe i-anion ye-oxygen, bese kuthi i-electron eyodwa eyodwa kumoya-mpilo yehle, ilahlekelwe yiqembu le-ethoxy, bese ikhiqiza i-1.2, 4-triazolone-5.
(II) Ukulungiswa kwama-heterocyclic compounds ngokusabela kwe-amide acetal ne-amide
Lena indlela ebikwe kakhulu yokungcola kwe-synthesis emashumini eminyaka amuva nje.Isenzo se-amide acetal silingana ne-Grignard reagent, kodwa isimo sokusabela se-amide acetal silula futhi sithambile.
I-Amide acetal inamaqembu amabili asebenzayo, i-reactivity ephezulu, kanye ne-methyl esebenzayo, ukusabela kwe-methylene ukwenza ama-amidine intermediates, kungaba ukusabela okuqhubekayo, ukuvalwa kwendandatho, kanye ne-Grignard reagent kanye ne-methylene reaction, ukwandisa kuphela i-carbon chain, ayikwazi ukusabela okuqhubekayo.Ngokwesibonelo, synthesis of furanochroone derivatives.
(3): i-amide acetal ne-hydroxyl, i-sulfhydryl compound reaction ukukhiqiza umoya-mpilo, izinhlanganisela ze-sulfur heterocyclic
Ukuhlanganiswa okungenhla kwe-furothulane kuyisibonelo esihle sokukhiqizwa kwe-acetal kokuphuma kokuphuma kwe-enamine kanye neqembu le-hydroxyl ngokuhlukanisa isigxobo se-endolateral, okuholela ku-oxy-containing heteramine:.Esinye isibonelo: i-catechol ne-DMF -- i-DMA yenza amasongo aqukethe umoya-mpilo phambi kwe-dichloromethane.
Ukusabela kwe-DMF -- DMA kanye ne-o-mercaptoaniline kungakhiqiza iringi ye-heterocyclic enesulfure, indlela yokusabela imi kanje
Indaba efundwayo yokusabela kokuvalwa kweringi ye-DMF-DMA kanye nokusabela komuntu siqu
(1) I-Batcho-Leimgruber indole synthesis
Ukulungiswa kwezinhlobonhlobo ze-Vindol ezivela ku-o-nitrotoluene.
Indlela yokusabela
Okokuqala, i-dimethylformamide dimethylacetal, ama-ion angalungile weqembu le-methoxy ashiya ukukhiqiza okuphakathi okusebenzayo.Ihlaselwa ama-carboanion akhiwa ukuchithwa kwe-o-nitrotoluene methyl hydrogen futhi ilahlekelwa i-methanol ukuze ithole i-enylamine eshiwo ngenhla.Umkhiqizo walesi sinyathelo, i-enamine, ufana ne-alkene ene-electron-withdrawing and electron-donating substitutives enamathiselwe nhlangothi zombili (Push-pull olefin i-polar kakhulu futhi ngokuvamile ibomvu ngokumnyama ngenxa yobubanzi obukhulu bokuhlangana ku-molecule. Esinyathelweni sesibili yokusabela, iqembu le-nitro lincishiswa libe yiqembu le-amino, lilandelwa yibhayisikili nokuqedwa ukuze kutholwe umkhiqizo wokugcina.
(2) Izithombe ezihlanganisiwe ze-pyridine derivatives
(3) Ukuhlanganiswa kokuphuma kwe-pyrazole