EDC·HCl CAS 25952-53-8 Coupling Reagent Purity >99.0% (T) Isithombe Esifakiwe Sefekthri

EDC·HCl CAS 25952-53-8 Coupling Reagent Purity >99.0% (T) Factory

Incazelo emfushane:

1-(3-Dimethylaminopropyl)-3-Ethylcarbodiimide Hydrochloride

Amazwi afanayo: EDC·HCl

I-CAS: 25952-53-8

Ubumsulwa: >99.0% (I-Argentmetric Titration)

Ukubukeka: I-Crystalline Powder Emhlophe

I-Coupling Reagent ye-Peptides Synthesis

Thintana: UDkt. Alvin Huang

Iselula/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Imikhiqizo Ehlobene

Omaka bomkhiqizo

Incazelo:

I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi ohamba phambili we-1-(3-Dimethylaminopropyl)-3-Ethylcarbodiimide Hydrochloride (EDC·HCl) (CAS: 25952-53-8) enekhwalithi ephezulu.I-Ruifu Chemical ihlinzeka ngochungechunge lwama-reagents avikelayo kanye nama-reagents ahlanganisayo.I-Ruifu inganikeza ukulethwa komhlaba wonke, intengo encintisanayo, amanani amancane nayinqwaba atholakalayo.Thenga i-EDC·HCl,Please contact: alvin@ruifuchem.com

Chemical Properties:

Igama Lekhemikhali	1-(3-Dimethylaminopropyl)-3-Ethylcarbodiimide Hydrochloride
Omqondofana	EDC·HCl;EDAC·HCl;EDCI·HCl;I-EDC Hydrochloride;I-EDAC Hydrochloride;I-N-(3-Dimethylaminopropyl)-N′-Ethylcarbodiimide Hydrochloride;I-1-Ethyl-3-(3-Dimethylaminopropyl)carbodiimide Hydrochloride;I-N-Ethyl-N'-(3-dimethylaminopropyl)carbodiimide Hydrochloride;Amanzi e-Soluble Carbodiimide
Isimo Sesitoko	In Stock, Mass Production
Inombolo ye-CAS	25952-53-8
I-Molecular Formula	C8H17N3·HCl
Isisindo samangqamuzana	191.70 g/mol
I-Melting Point	110.0~115.0℃
Ukuminyana	0.877 g/mL at 20℃(lit.)
I-Refractive Index n20/D	1.461
Gcina Ngaphansi Kwegesi Ye-inert	Gcina Ngaphansi Kwegesi Ye-inert
Kuyazwela	I-Hygroscopic.Kuyazwela Umswakama, Kuyazwela Ukushisa
Ukuncibilika kwamanzi	Incibilika Ngokuphelele Emanzini
Ukuncibilika	Incibilika ku-Dimethylformamide, Utshwala
Isikhathi Sokugcina.	Indawo epholile neyomile (<5℃)
I-COA ne-MSDS	Iyatholakala
Isigaba	Ama-Reagents wokuhlanganisa
Ibhrendi	I-Ruifu Chemical

Imininingwane:

Izinto	Amazinga Wokuhlola	Imiphumela
Ukubukeka	I-Crystalline Powder Emhlophe	Iyahambisana
I-Melting Point	110.0~115.0℃	112.0~114.0℃
Amanzi nguKarl Fischer	<0.50%	0.10%
Izinsalela ekushiseni	<0.10%	0.04%
Ukuhlanzeka (I-Argentmetric Titration)	>99.0%	99.70%
Ukuhlanzeka / Indlela Yokuhlaziya	>99.0% (HPLC)	Iyahambisana
I-Infrared Spectrum	Ivumelana Nesakhiwo	Iyahambisana
Ukunyibilika ku-H2O (100 mg/mL)	Ayinambala ukuya kokuphuzi kakhulu, Kucacile	Dlula
Isiphetho	Umkhiqizo uhloliwe futhi uthobelana nemibandela enikeziwe

Iphakheji/Isitoreji/Ukuthumela ngomkhumbi:

Iphakheji:Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Kuyazwela Umswakama.Gcina ezitsheni ezivaliwe endaweni epholile futhi eyomile (<5℃) kude nezinto ezingahambelani.Vikela ekukhanyeni nakumswakama.
Ukuthumela:Thumela emhlabeni wonke nge-FedEx / DHL Express.Nikeza ukulethwa okusheshayo nokuthembekile.

Indlela Yokuhlola:

Izakhiwo: Lo mkhiqizo uyimpushana emhlophe ecwebezelayo.
2. Ukunqunywa kokuqukethwe:
2.1 Izinsimbi nama-reagents: i-potentiometric titrator, isisombululo se-nitric acid (12.5 wt%), isixazululo esijwayelekile se-AgNO3 (0.1mol/L)
2.2 Ukulungiswa nokusebenza kwesampula:
I-200 kuya ku-220mg yachithwa ku-40ml wamanzi acwecwe, futhi ngemva kwe-5ml yesisombululo se-nitric acid, isisombululo sancibilika nge-nitrate yesiliva.
Uketshezi lwaluthithiwe lwaze lwafika ekugcineni.Ifomula yokubala okuqukethwe komkhiqizo imi kanje:
X = (VAgNO3*19.171)/W,
X- Iphesenti le-EDC.HCl, 100%.
V-Ivolumu esetshenziswe isisombululo esijwayelekile se-AgNO3, ml
I-19.171-1ml isisombululo esijwayelekile se-AgNO3 (0.1mol/L) sidliwe I-EDC.HCl mass, mg;
W - isampula yesisindo, mg;
Indlela yenziwa izikhathi ezintathu ngokuhambisana futhi isilinganiso sathathwa, futhi iphutha akufanele lidlule u-0.3%.Okuqukethwe komkhiqizo kufanele kube >99.0%.
3. Iphuzu elincibilikayo: ngokwendlela yokunquma iphuzu lokuncibilika (Isithasiselo VII C soshicilelo lwe-Chinese Pharmacopoeia 2010), indawo yokuncibilika yalo mkhiqizo kufanele ibe ngu-110.0~115.0℃.
4. Ukunqunywa kokuqukethwe kwamanzi: ngokwendlela yokulinganisa umswakama (indlela ye-KF) yokunquma, okuqukethwe kwamanzi alo mkhiqizo kufanele kube ngu-<0.50%.
5. Isitoreji: Gcina endaweni emnyama nepholile eyomile (<5℃).
6. Isikhathi sokubukeza: unyaka owodwa

Umzila Wokwenziwa:

Izinzuzo:

Amandla Anele: Izinsiza ezanele kanye nochwepheshe

Isevisi Yobuchwepheshe: Isevisi yokuthenga yokuma eyodwa

Iphakheji le-OEM: Iphakheji yangokwezifiso kanye nelebula iyatholakala

Ukulethwa Okusheshayo: Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe

Impahla Ezinzile: Gcina isitoko esinengqondo

Ukusekelwa Kwezobuchwepheshe: Isixazululo sezobuchwepheshe siyatholakala

Isevisi Yokuhlanganisa Ngokwezifiso: Isukela kumagremu kuye kumakhilo

Ikhwalithi Ephezulu: Kusungulwe uhlelo oluphelele lokuqinisekisa ikhwalithi

I-FAQ:

Indlela Yokuthenga?Sicela uxhumaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

Iminyaka engu-15 Yokuhlangenwe nakho?Sinesipiliyoni seminyaka engaphezu kwe-15 ekwakhiweni nasekuthumeleni kwamanye amazwe uhla olubanzi lwezinga eliphezulu lokuxhumanisa imithi noma amakhemikhali amahle.

Izimakethe Eziyinhloko?Thengisa emakethe yasekhaya, eNyakatho Melika, eYurophu, eNdiya, eKorea, eJapane, e-Australia, njll.

Izinzuzo?Ikhwalithi ephezulu, intengo ethengekayo, izinsizakalo ezichwepheshile nokusekelwa kobuchwepheshe, ukulethwa okusheshayo.

IkhwalithiIsiqiniseko?Isistimu yokulawula ikhwalithi eqinile.Imishini yobuchwepheshe yokuhlaziya ifaka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, NOMA, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njll.

Amasampula?Imikhiqizo eminingi inikeza amasampula wamahhala wokuhlolwa kwekhwalithi, izindleko zokuthumela kufanele zikhokhelwe amakhasimende.

Ukuhlolwa Kwemboni?Wamukelekile ekucwaningweni kwemboni.Sicela wenze i-aphoyintimenti kusengaphambili.

I-MOQ?Ayikho i-MOQ.I-oda elincane liyamukeleka.

Isikhathi sokuthumela? Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe.

Ezokuthutha?By Express (FedEx, DHL), by Air, by Sea.

Amadokhumenti?Ngemuva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njll.

Custom Synthesis?Ingahlinzeka ngezinsizakalo zokwenziwa ngokwezifiso ukuze zilingane kangcono nezidingo zakho zocwaningo.

Imigomo Yokukhokha?I-invoyisi ye-Proforma izothunyelwa kuqala ngemva kokuqinisekiswa kwe-oda, kufakwe nemininingwane yethu yasebhange.Inkokhelo nge-T/T (Telex Transfer), PayPal, Western Union, njll.

25952-53-8 - Ubungozi Nokuphepha:

Amakhodi Engozi
R34 - Ibangela ukusha
R36/37/38 - Ukucasula amehlo, uhlelo lokuphefumula kanye nesikhumba.
R41 - Ingozi yokulimala okubi emehlweni
R37/38 - Ukucasula uhlelo lokuphefumula kanye nesikhumba.
R20/21/22 - Kuyingozi ngokuhogela, ukuthintana nesikhumba futhi uma ukugwinyile.
Incazelo Yokuphepha
S26 - Uma uthintana namehlo, geza ngokushesha ngamanzi amaningi futhi ufune iseluleko sezokwelapha.
I-S36/37/39 - Gqoka izingubo zokuzivikela ezifanele, amagilavu nokuvikela iso/ubuso.
S45 - Uma kwenzeka ingozi noma uzizwa ungaphilile, funa iseluleko sezokwelapha ngokushesha (bonisa ilebula noma nini lapho kunokwenzeka.)
I-S37/39 - Gqoka amagilavu afanelekile kanye nokuvikela iso/ubuso
I-S36 - Gqoka izingubo ezifanele zokuzivikela.
Omazisi be-UN UN 2735 8/PG 3
I-WGK Germany 3
I-RTECS FF2200000
I-FLUKA BRAND F AMAKHODI 1-3-10
I-TSCA Y
I-HS Code 2925290090
I-Hazard Note Irritant
Ubuthi be-LD50 bokungena emthanjeni kumagundane: 56mg/kg

Isicelo:

I-1-(3-Dimethylaminopropyl) -3-Ethylcarbodiimide Hydrochloride (EDC·HCl) (CAS: 25952-53-8) iyimpushana emhlophe ecwebezelayo, ephunduka kalula, encibilika emanzini, encibilika ku-ethanol, esetshenziswa njenge-reagent esebenzayo ye-carboxyl. amaqembu ku-amide synthesis, esetshenziselwa ukwenza amaqembu e-phosphate asebenze, ukuxhumanisa amaprotheni nama-nucleic acid, kanye nokukhiqizwa kwama-immunocouplers.I-EDC-HCl isetshenziswa kuhlu lwe-pH lwe-4.0-6.0 futhi ivame ukusetshenziswa ngokuhambisana ne-N-Hydroxysuccinimide (NHS) noma i-N-Hydroxysulfosuccinimide usawoti we-sodium ukuze kuthuthukiswe ukusebenza kahle kokuhlanganisa.
I-EDC·HCl i-carbodiimide encibilika emanzini, isetshenziswa kakhulu ukuhlanganisa i-peptide.I-EDC·HCl isetshenziswa njenge-ejenti evuselela i-carboxyl.Idlala indima ebalulekile ekwenzeni ama-biomolecules amakhulu ahlanganiswe ne-N-hydroxysuccinimide.Ibuye isetshenziswe ku-acylation ye-phosphoranes.
Okuphuma emanzini okuncibilika kwe-carbodiimide kuyasiza ekuhlanganiseni i-haptens kumaprotheni nama-polypeptides.Isetshenziselwa ukuguqula ama-NMDA receptors futhi njenge-ejenti ejiya ekuhlanganiseni kwe-peptide.Inzuzo enkulu yokuhlanganisa i-EDAC ukususwa kalula kwe-reagent eyeqile kanye ne-urea ehambisanayo ngokugeza nge-asidi exubile noma amanzi.I-Carbodiimides igqugquzela ukwakheka kwama-amide bond, ama-carboxylic acid, nama-amine ngokwenza i-carboxylate yakhe i-O-acylurea.Lokhu okuphakathi kungahlaselwa i-amine ngokuqondile ukuze kwakhe i-amide.I-EDAC ikhishwa njengokuphuma kwe-urea encibilikayo.
I-EDC·HCl ingasetshenziselwa ukuhlanganiswa kwama-amide.Isetshenziswa njenge-ejenti yokuhlanganisa ekuhlanganisweni kwama-esters asuka ku-carboxylic acid kusetshenziswa i-dimethylaminopyridine njenge-catalyst.
Ikakhulukazi kunama-ejenti amathathu ajwayele ukusetshenziswa: i-DCC, i-DIC kanye ne-EDC·HCl.Ukusetshenziswa kwalolu hlobo lwe-ejenti yokujiya ngokuvamile kudinga ukungezwa kwama-acylation catalysts noma ama-activator, njenge-DMAP, HOBt, njll. Njengoba ukungezwa okumaphakathi kwe-asidi ku-carbodiimide esigabeni sokuqala sokusabela kuzinzile, uma i-acylation i-catalyst ayisetshenziselwa ukuyiguqula ibe i-ester esebenzayo ehambisanayo noma i-amide esebenzayo, izohlelwa kabusha ibe umkhiqizo ohambisanayo ozinzile we-urea (Umzila B).I-activator ye-condensation: Kunezinhlobo ezilandelayo ze-condensation activator evame ukusetshenziswa.Njengamanje, i-4-N, N-dimethylpyridine (DMAP) isetshenziswe kabanzi ukuze kuthuthukiswe ukusabela okuhlukahlukene kwe-acylation.Kwesinye isikhathi i-4-PPY ingasetshenziswa uma umphumela we-catalytic we-DMAP ungemuhle.Ngokusho kwezincwadi ezifanele, ikhono layo lokuvuselela liphakeme ngokuphindwe izikhathi eziyinkulungwane kune-DMAP.phakathi kwama-condenser amathathu asetshenziswa kakhulu, i-DCC ne-DIC ishibhile.Ngokuvamile i-DCC ne-DMAP zisetshenziswa ndawonye.Enye yezinto ezimbi kakhulu zokusebenzisa i-DCC ukuthi omunye umkhiqizo wokusabela, i-dicyclohexylurea, inokuncibilika okuncane esigabeni esivamile sezinto eziphilayo kodwa iyancibilika kancane, ngakho-ke kunzima ukuyisusa ngokuphelele ngokusebenzisa ezinye izindlela zokuhlanza ezivame ukusetshenziswa, ukuvuselela kabusha, ikholomu yechromatography, njll.;ngenxa yokuthi ukunyibilika kwe-dicyclohexylurea ku-ether kuncane kakhulu kunezinye izincibilikisi, ngakho-ke, ukwelashwa kwalolu hlobo lokusabela ngokuvamile kuhwamulisa i-solvent yokusabela futhi kwengeze i-ether, futhi kuhlunga iningi le-dicyclohexylurea ngaphambi kokwelashwa okwengeziwe.Ngenxa yokuthi i-disopropylurea ekhiqizwe i-DIC inokunyibilika kangcono kuzinyibilikisi zemvelo ezijwayelekile, imvamisa isetshenziswa ekuhlanganiseni kwamakhemikhali e-solid-phase synthesis.I-EDCI okwamanje isetshenziswa kakhulu kumakhemikhali okwelapha.Esinye sezici zayo eziyinhloko ukuthi i-urea ekhiqizwa ngemva kokusabela iyancibilika emanzini futhi kulula ukuyigeza.Ngokuvamile, i-EDCI ihlanganiswe ne-HOBt (qaphela: lokhu kusabela kwe-HOBt ngokuvamile kudingekile, ngaphandle kwalokho kungase kuholele ekuvuneni okuphansi kakhulu kokufiphala).Kwesinye isikhathi uma isithiyo se-asidi sesikhundla sisikhulu noma kuneqembu elikhipha i-electron, ukusabela kuzohlala esinyathelweni se-ester esisebenzayo (i-ester esebenzayo inesiginali ye-mass spectrum enamandla futhi ingatholwa yi-MS noma i-LC-MS).