I-Entecavir Monohydrate CAS 209216-23-9 API Factory High Quality Antiviral Hepatitis B Infection

Incazelo emfushane:

Igama Lekhemikhali: I-Entecavir Monohydrate

I-CAS: 209216-23-9

Ukubukeka: I-Crystalline Powder Emhlophe noma Cishe Emhlophe

I-antiviral esetshenziswa ekwelapheni i-Hepatitis B Infection

Ikhwalithi ephezulu ye-API, Ukukhiqiza Kwezentengiso

Inquiry: alvin@ruifuchem.com

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Incazelo:

Ukunikezela Komkhiqizi Ngokuhlanzeka Okuphezulu kanye Nekhwalithi Ezinzile
Igama Lekhemikhali: I-Entecavir Monohydrate
I-CAS: 209216-23-9
Isetshenziswa ekwelapheni i-Hepatitis B Infection
Ikhwalithi ephezulu ye-API, Ukukhiqiza Kwezentengiso

Chemical Properties:

Igama Lekhemikhali	I-Entecavir Monohydrate
Omqondofana	I-Entecavir Hydrate;9-[(1S,3R,4S)-4-Hydroxy-3-(hydroxymethyl)-2-methylenecyclopenyl]guanine Monohydrate
Inombolo ye-CAS	209216-23-9
Inombolo yeCAT	I-RF-API79
Isimo Sesitoko	Esitokweni, Isikali Sokukhiqiza Sifika Emakhulwini Amakhilogremu
I-Molecular Formula	I-C12H17N5O4
Isisindo samangqamuzana	295.3
I-Melting Point	>220℃
Ukuminyana	1.81
Isimo Sokuthumela	Kuthunyelwe Ngaphansi Kwezinga Lokushisa Le-Ambient
Ibhrendi	I-Ruifu Chemical

Imininingwane:

Into	Imininingwane
Ukubukeka	I-Crystalline Powder Emhlophe noma Cishe Emhlophe
Ukuncibilika	I-Soluble Ngokukhululekile ku-Dimethylformamide, Incibilika Kancane Emanzini, i-Ethanol ne-Methanol
Ukuhlonza IR	I-Spectrum yesampula ihambisana naleyo yezinga lereferensi
Ukuhlonza HPLC	Isikhathi sokugcinwa kwesampula yokuhlola sihambisana naleso sezinga lesithenjwa
Okuqukethwe kwamanzi (nge-KF)	5.5%~6.5%
I-Specific Optical Rotation	+24.0° ukuya +30.0° (DMF: MeOH=1:1 C=1%) (entweni engenamanzi)
Izinsalela ekushiseni	≤0.10%
Izinto Ezihlobene
I-Furoentecavir	≤0.10%
I-Entecavir 1-Epimer	≤0.10%
I-Entecavir 3-Epimer	≤0.10%
8-Methyoxy Entecavir	≤0.10%
I-Entecavir 4-Epimer	≤0.10%
I-8-Hydroxy Entecavir	≤0.10%
I-4-Dimethylsilyl Entecavir	≤0.10%
I-Entecavir Inhlanganisela Ehlobene A	≤0.10%
Noma Ikuphi Ukungcola Okungashiwongo	≤0.10%
Ukungcola Okuphelele	≤0.30%
Izincibilikisi Ezisele
I-Methanol	≤600ppm
I-Dichloromethane	≤300ppm
I-Ethyl Acetate	≤1000ppm
I-Tetrahydrofuran	≤720ppm
I-Toluene	≤890ppm
I-Benzyl Chloride	≤1000ppm
I-Benzyl Alcohol	≤1000ppm
Umkhawulo weMicrobial
Izibalo eziphelele ze-Aerobic	≤100cfu/g
Imvubelo kanye Nesikhunta	≤10cfu/g
Escherichia Coli	Akufanele Kutholwe
Izinsimbi Ezisindayo	≤10ppm
Isivivinyo	98.0%~102.0% (HPLC; kusisekelo se-anhydrous)
Usayizi Wezinhlayiyana	U-95% wezinhlayiya kufanele ube phakathi kuka-125um
Izinga Lokuhlola	Izinga lebhizinisi;I-United States Pharmacopoeia (USP) Standard
Ukusetshenziswa	I-antiviral esetshenziswa ekwelapheni i-Hepatitis B Infection

Iphakheji nesitoreji:

Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, isigubhu seCardboard, 25kg/Drum, noma ngokwezidingo zekhasimende.

Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni, umswakama kanye nezinambuzane.

Izinzuzo:

I-FAQ:

Isicelo:

I-Entecavir Monohydrate (i-CAS 209216-23-9) iyisidakamizwa somlomo esisetshenziselwa ukwelashwa kwe-Hepatitis B Virus (HBV) ukutheleleka.I-Entecavir Monohydrate iyi-analog ye-nucleoside (ikakhulukazi, i-analogue ye-guanine) evimbela ukubhalwa okuphambene, ukuphindaphinda kwe-DNA nokulotshwa ku-vira.Iwuhlobo olusha lwezidakamizwa ze-cyclopenyl acyl guanosine anti-Hepatitis B ezinemiphumela yayo yezemithi efana ne-Entecavir.Isetshenziswa ngokomtholampilo ekwelapheni i-Hepatitis B yabantu abadala lapho kunokuphindaphinda kwegciwane okusebenzayo, ukwanda kwe-serum transaminase ALT noma izilonda ezisebenzayo ezivezwa ku-histology yesibindi.I-Entecavir Monohydrate iyi-inhibitor enamandla futhi ekhethayo ye-HBV, ene-EC50 ye-3.75 nM kuseli ye-HepG2.I-Entecavir iyi-reverse transcriptase inhibitor.Ivimbela i-Hepatitis B Virus (HBV) ukuthi ingaphindaphindi futhi yehlise inani legciwane emzimbeni.