I-Erlotinib Hydrochloride CAS 183319-69-9 Ubumsulwa >99.0% (HPLC)

Incazelo emfushane:

Igama Lekhemikhali: I-Erlotinib Hydrochloride

Synonym: Erlotinib HCl;Tarceva

CAS: 183319-69-9

Ukuhlanzeka (HPLC): >99.0%

Ukubukeka: I-Crystalline Powder Emhlophe ukuya Kokumhlophe

Thintana: UDkt. Alvin Huang

Iselula/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Imikhiqizo Ehlobene

Omaka bomkhiqizo

Incazelo:

Umkhiqizi ohamba phambili nomphakeli we-Erlotinib Hydrochloride Intermediates
I-Erlotinib Hydrochloride CAS 183319-69-9
3-Ethynylaniline CAS 54060-30-9
6,7-Bis(2-Methoxyethoxy)-3H-Quinazolin-4-one CAS 179688-29-0
Please contact: alvin@ruifuchem.com

Chemical Properties:

Igama Lekhemikhali	I-Erlotinib Hydrochloride
Omqondofana	I-Erlotinib HCl;Tarceva;I-CP-358774 Hydrochloride;I-6,7-Bis(2-methoxyethoxy) -4-(3-ethynylanilino)quinazoline Hydrochloride;N-(3-Ethynylphe nyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine HCl
Inombolo ye-CAS	183319-69-9
Inombolo yeCAT	I-RF-PI2242
Isimo Sesitoko	Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani
I-Molecular Formula	I-C22H24ClN3O4
Isisindo samangqamuzana	429.90
Ibhrendi	I-Ruifu Chemical

Imininingwane:

Into	Imininingwane
Ukubukeka	I-Crystalline Powder emhlophe ukuya kokumhlophe
Ukuhlonza	A: IR: Ihambisana ne-Reference Spectrum B: I-HPLC: Ihambisana ne-Reference RT
Ukuncibilika	Incibilika Kancane Kancane Emanzini, Incibilika Kancane ku-Methanol futhi Ayincibiliki Kakhulu ku-Acetonitrile, i-Acetone, i-Ethyl Acetate ne-Hexane
I-Melting Point	223.0~229.0℃
Ukulahlekelwa Ekumisweni	<0.50%
Izinsalela ekushiseni	<0.20%
Izinsimbi Ezisindayo	<20ppm
Ukungcola Okukodwa	<0.50%
Ukungcola Okuphelele	<1.00%
Izincibilikisi Ezisele
I-Pyridine	<4000ppm
I-Chloroform	<4000ppm
I-DMF	<3000ppm
Ukuhlanzeka / Indlela Yokuhlaziya	>99.0%
Indlela Yokuhlola / Yokuhlaziya	98.5%~101.0% (Ibalwe Ngokusekelwe I-Anhydrous)
Izinga Lokuhlola	I-Enterprise Standard
Ukusetshenziswa	I-API

Iphakheji nesitoreji:

Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwemfuneko yekhasimende

Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni nakumswakama

Izinzuzo:

I-FAQ:

Isicelo:

I-Erlotinib Hydrochloride (i-CAS: 183319-69-9) iyi-molecule encane ye-epidermal growth factor receptor tyrosine kinase reversible inhibitor, isetshenziswa kakhulu ekwelapheni umdlavuza wamaphaphu osethuthuke kakhulu endaweni noma ongewona omncane weseli kanye nomugqa wesibili noma imigqa emithathu yokwelashwa umdlavuza we-pancreatic.I-Erlotinib Hydrochloride yavunywa ngoNovemba, 2004, ukuze yelashwe umdlavuza wamaphaphu othuthukisiwe noma we-metastatic non-smallcell.Ingokwesigaba esifanayo ne-Gefitinib, enye i-quinazoline egunyazwe ukwelashwa komdlavuza wamaphaphu othuthukisiwe, kodwa enezici ze-pharmacokinetic ezithuthukisiwe.I-molecule yasungulwa yi-Pfizer futhi ukuthuthukiswa kwaqalwa ngokubambisana ne-OSI, eyathatha amalungelo aphelele esidakamizwa lapho i-Pfizer ihlanganiswa no-Warner Lambert.Ngokulandelayo, i-Genentech/Roche yangena esivumelwaneni selayisense ne-OSI ukuze ithuthukise futhi imakethe umuthi e-US nasemhlabeni wonke.I-Selective epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor.I-Antineoplastic.I-Erlotinib Hydrochloride iyi-HER1/EGFR inhibitor ene-IC50 ye-2 nM.I-Erlotinib HCl itholakala njengamaphilisi angama-25-, 100-, kanye ne-150-mg yokuphathwa ngomlomo.