I-Etravirine TMC-125 CAS 269055-15-4 Assay ≥99.0% (HPLC) API Factory High Purity
Umkhiqizi onokuhlanzeka Okuphezulu kanye Nekhwalithi Ezinzile
Igama Lekhemikhali: Etravirine (I-TMC-125)
I-CAS: 269055-15-4
Ikhwalithi ephezulu ye-API, Ukukhiqiza Kwezentengiso
Igama Lekhemikhali | I-Etravirine |
Omqondofana | I-TMC-125 |
Inombolo ye-CAS | 269055-15-4 |
Inombolo yeCAT | I-RF-API54 |
Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani |
I-Molecular Formula | I-C20H15BrN6O |
Isisindo samangqamuzana | 435.28 |
Ukuminyana | 1.439 g/cm3 |
Isimo Sokuthumela | Ngaphansi Kwezinga Lokushisa Le-Ambient |
Ibhrendi | I-Ruifu Chemical |
Into | Imininingwane |
Ukubukeka | Impushana Eqinile Emhlophe |
Ukuhlonza | Nge-IR, HPLC |
I-Melting Point | 211.0~216.0℃ |
Okuqukethwe Amanzi | ≤0.50% |
Izinsalela ekushiseni | ≤0.20% |
Izinsimbi Ezisindayo | ≤20ppm |
Noma Ikuphi Ukungcola Okukodwa | ≤0.50% |
Ukungcola Okuphelele | ≤1.0% |
Isivivinyo | ≥99.0% (HPLC) |
Izinga Lokuhlola | I-Enterprise Standard |
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, isigubhu seCardboard, 25kg/Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni, umswakama kanye nezinambuzane.
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I-Etravirine (TMC-125) (CAS 269055-15-4) iyisizukulwane sesibili i-non-nucleoside reverse transcriptase inhibitor (NNRTI) esetshenziselwa ukwelapha i-HIV.Ikhonjiswe ukuthi isetshenziswe ngokuhlanganyela namanye ama-antiretroviral ekwelapheni i-HIV-1 ezigulini ezinolwazi lokwelashwa ezinobufakazi bokuphindaphinda kwegciwane kanye nezinhlobo ze-HIV-1 ezimelana nama-NNRTI atholakalayo kanye nezinye izidambisi gciwane.Ama-NNRTI, kanye ne-nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs/NtRTIs), ziyizingxenye ezibalulekile zemithi eyinhlanganisela esetshenziswa njengamanje ukwelapha ukutheleleka nge-HIV-1.Ama-NRTIs/NtRTIs enza ngokuncintisana nama-nucleotide substrates we-reverse transcriptase ukuze afakwe ku-DNA yegciwane kanye nokuqedwa kweketango okulandelayo.Ngokuphambene, ama-NNRTI abophezela endaweni ye-allosteric ye-enzyme futhi aphazamise umsebenzi we-DNA polymerase ngokudala izinguquko zokuvumelana endaweni ye-catalytic.
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