I-Fmoc-Gly-OH CAS 29022-11-5 Fmoc-Glycine Purity >99.0% (HPLC) Factory

I-Fmoc-Glycine (Fmoc-Gly-OH) (CAS: 29022-11-5) iwuhlobo lwe-Glycine oluvikelwe yi-N-Fmoc.I-Glycine iyi-amino acid engabalulekile.Ama-Fmoc-amino acids, asetshenziswa ku-peptide synthesis, asetshenziswa njenge-organic synthesis intermediate, pharmaceutical intermediate, reagent biochemical noma i-chemical reagent.
Isingeniso: I-Fmoc-Glycine i-Glycine ivikelwe yi-Fmoc.I-Fluorene methoxycarbonyl (Fmoc) iyiqembu elivikelayo elizwela isisekelo, elingasetshenziswa emanzini e-ammonia agxilile noma i-dioxane-methanol-4N NaOH(30:9:1) kanye ne-piperidine, i-ethanolamine, i-cyclohexylamine, i-1,4-Dioxane, i-pyrrolidone enye isixazululo se-ammonia 50% dichloromethane.Ngaphansi kwezimo ze-alkaline ezibuthakathaka njenge-sodium carbonate noma i-sodium bicarbonate, iqembu lokuvikela i-Fmoc ngokuvamile lethulwa yi-Fmoc-Cl noma i-Fmoc-OSu.
Isicelo: I-Fmoc-Glycine i-Fmoc-protected Glycine, esetshenziswa kakhulu ukwenza ama-polypeptides.Umehluko wamaqembu okuvikela i-amino acid unomthelela omkhulu ekusebenzeni kahle nasekuvunweni kwe-polypeptide synthesis.Isibonelo, i-Fmoc-Glycine ingasetshenziselwa ukulungisa i-glycine derivative corrosion inhibitor, futhi iqembu le-Fmoc-protecting kanye neketango elide le-hydrophobic lixhunywe ku-molecule ye-Glycine ngokusabela kwe-amidation, kanye ne-heteroatom (N, O, njll.) Noma amabhondi angagcwele) kanye neringi ye-bisphenyl equkethe ama-electron angu-π akhangisiwe ensimbi, futhi iketango elide le-hydrophobic livimba ama-molecule wamanzi, ukuze lenze ifilimu evikelayo endaweni yensimbi ukuze kufezwe injongo yokuvikela ukugqwala.
Ukulungiselela: Izinyathelo eziqondile zokwenziwa kwe-Fmoc-Glycine zimi kanje: I-3.0g Glycine incibilika ku-115ml ka-10% Na2CO3, ipholiswe ku--4~0℃, 11.2g Fmoc-Cl incibilike ku-35.0ml we-acetone futhi yengezwa ohlelweni lwe-dropwise, Ngemva kwalokho dropwise, igqugquzele e okugeza ice for 30min, bese ugovuze ekamelweni lokushisa 2.0h.Inqubekelaphambili yokusabela iqashwe nge-chromatography yesendlalelo esincanyana.Ngemuva kokuthi ukusabela kuqediwe, i-400ml yamanzi yathululelwa emanzini, i-ether yakhishwa kabili, ipholile futhi ilungiswa ku-pH2 nge-concentrated hydrochloric acid, inani elikhulu eliqinile elimhlophe lavulwa, i-50 ml ye-ethyl acetate yakhishwa kathathu, i-magnesium anhydrous. i-sulfate yomiswa, i-solvent yahlanjululwa ngaphansi kwengcindezi encishisiwe, futhi i-petroleum ether yasetshenziselwa ukwehla ukuze kutholwe i-11.5g ye-Fmoc-Glycine.Ngemuva kokuhlanzwa, ukuhlanzeka komkhiqizo kwaba ngu-97.35% ngokusebenza okuphezulu kwe-chromatography ye-liquid.