I-Fmoc-Leu-OH CAS 35661-60-0 N-Fmoc-L-Leucine Purity >99.0% (HPLC) Factory
I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi ohamba phambili we-N-Fmoc-L-Leucine (Fmoc-Leu-OH) (CAS: 35661-60-0) enekhwalithi ephezulu.I-Ruifu Chemical ihlinzeka ngochungechunge lwama-amino acid.Singahlinzeka ngezidingo zomhlaba wonke, amanani ancintisanayo, amanani amancane kanye nenqwaba etholakalayo.Thenga i-Fmoc-Leu-OH,Please e-mail: alvin@ruifuchem.com
| Igama Lekhemikhali | I-N-Fmoc-L-Leucine |
| Omqondofana | Fmoc-Leu-OH;Fmoc-L-Leu-OH;I-Fmoc-L-Leucine;N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-Leucine;I-N-(9-Fluorenylmethoxycarbonyl)-L-Leucine |
| Isimo Sesitoko | Esitokweni, Amandla Okukhiqiza Amathani Njalo Ngenyanga |
| Inombolo ye-CAS | 35661-60-0 |
| I-Molecular Formula | I-C21H23NO4 |
| Isisindo samangqamuzana | 353.42 g/mol |
| I-Melting Point | 153.0 ukuze 160.0 ℃ |
| Ukuminyana | 1.207±0.06 g/cm3 |
| Kuyazwela | I-Hygroscopic |
| I-Solubility ku-Methanol | Cishe Ukungafihli |
| Isikhathi Sokugcina. | Indawo epholile neyomile (2~8℃) |
| I-COA ne-MSDS | Iyatholakala |
| Isigaba | I-Fmoc-Amino Acids |
| Ibhrendi | I-Ruifu Chemical |
| Izinto | Amazinga Wokuhlola | Imiphumela |
| Ukubukeka | Impushana Emhlophe | Impushana Emhlophe |
| Ukuzungezisa Okuthile [α]20/D | -25.0°±2.0° (C=1 ku-DMF) | -24.6° |
| I-Melting Point | 153.0 ukuze 160.0 ℃ | 155.1℃ |
| I-TLC | ≥98.0% | >98.0% |
| I-Optical Purity | <0.30% D-Enantiomer | Iyahambisana |
| Ukucaca Kwesixazululo | 0.3 amagremu ku-2ml Isixazululo Esicacile se-DMF | Iyahambisana |
| Ukuhlolwa kwe-Kaiser | <0.05% | <0.05% |
| Amanzi nguKarl Fischer | <0.50% | 0.12% |
| Ukulahlekelwa Ekumisweni | <0.50% (60℃, 2h) | 0.15% |
| I-Fmoc-β-Ala-OH | <0.20% (HPLC) | Iyahambisana |
| I-Fmoc-β-Ala-Leu-OH | <0.10% (HPLC) | Iyahambisana |
| I-Fmoc-Leu-Leu-OH | <0.10% (HPLC) | Iyahambisana |
| Fmoc-Ile-OH | <0.10% (HPLC) | Iyahambisana |
| I-Assay Free Amino Acid | <0.20% (GC) | Iyahambisana |
| I-Ethyl Acetate | <0.50% (GC) | Iyahambisana |
| Ukuhlanzeka / Indlela Yokuhlaziya | >99.0% (HPLC) | 99.85% |
| I-Mass Spectrum | Ngokuvumelana Nezinga | Iyahambisana |
| I-NMR Spectrum | Ngokuvumelana Nezinga | Iyahambisana |
| Isiphetho | Umkhiqizo uhloliwe futhi uthobelana nezicaciso | |
Iphakheji: Ibhodlela eliFluorinated, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile (2~8℃) kude nezinto ezingahambelani.Vikela ekukhanyeni nakumswakama.
Inqubo yokuhlola
1. Ukubukeka
-- Ukuhlola okubonakalayo
2. Ubumsulwa (HPLC)
2.1 Ithuluzi
Ukusebenza okuphezulu kwe-chromatography ye-liquid, umtshina we-PDA.
Ibhalansi yokuhlaziya ye-elekthronikhi
2.2 I-Reagent
I-Acetonitrile (ibanga le-chromatographic), i-Trifluoroacetic acid (ibanga le-chromatographic)
2.3 Izimo zeChromatographic
2.3.1 Ikholomu: YMC-ODS-AM, 5μL, 250x4.6 mm
2.3.2 Ubude begagasi bokutholwa: INC220nm
Izinga lokugeleza: 1.0mL/min
Usayizi wesampula: 10μL (inkomba)
I-Diluent: i-acetonitrile
Isikhathi sokuqoqwa kwedatha: 25.00min
2.4 Ukulungiselela isigaba sikamakhalekhukhwini
Isigaba seselula A (0.1% samanzi e-trifluoroacetic acid): amunca kahle i-2.0ml trifluoroacetic acid, ehlanjululwe ngamanzi abe ngu-2000ml, xuba kahle, futhi ukhiphe umoya;
Isigaba seselula B (0.1% i-acetonitrile trifluoroacetic acid): thatha ngokunembile i-2.0ml trifluoroacetic acid, ihlanjululwe ku-2000ml nge-acetonitrile, ukuxuba nokukhipha umoya;
Isikhathi (amaminithi) A% B%
0.00 90 10
13.00 10 90
18.00 10 90
18.01 90 10
23.00 90 10
2.6 Ukulungiswa kwesixazululo sesampula
Kala bese uncibilikisa isampula engu-0.1g nge-acetonitrile bese uncibilikisa ibe ngu-100ml, xukuza kahle ukuze uyisebenzise, noma ukugxila okufanayo.Lungiselela amasampula amabili ngokuhambisana.
2.7 Ukunqunywa kwesampula
Hlaziya isampula ngokuya ngenqubo yamasampula elandelayo:
Umjovo ongaphezu ko-1 wesixazululo esingenalutho
Isampula yenaliti eyisampula yesixazululo 1#
1 isampula yenaliti yesixazululo 2#
2.8 Ukubalwa kwemiphumela
2.8.1 Indlela yokujwayela yendawo ephakemeyo yasetshenziswa ukubala ubumsulwa be-HPLC ngokudonsa indawo engenalutho.
2.8.2 Isilinganiso sokuchezuka kwesihlobo sokuhlanzeka kwezinalithi ezimbili akumele sibe ngaphezu kuka-1%
2.8.3 Uma imiphumela yayo yomibili imijovo ihlangabezana nemibandela yokwamukelwa, ukuhlanzeka okumaphakathi kuthathwa njengomphumela wokugcina.
3, Indawo encibilikayo -- RY-1 ithuluzi lokuncibilika
4. Ukulahlekelwa endleleni yokuhlola yokomisa
4.1 Izinsimbi:
Ihhavini yokomisa i-thermostatic kagesi, ibhalansi engu-1/10,000.
4.2 Inqubo:
Ebhodleleni lesisindo esiyisicaba elinesisindo esingaguquki kanye nesembozo somlomo womhlabathi omiswe ngokweqile, kala igremu elingu-1 (elinembile ukuya ku-0.0001 igremu) lesampula.Isampula kufanele isatshalaliswe ngokulinganayo ngaphansi kwebhodlela lesisindo ngogqinsi olungekho ngaphezu kuka-10mm, ifakwe kuhhavini wokomisa kagesi we-thermostatic, yome ku-105 ~ 110 ℃ amahora angu-3, bese ingena ekamelweni lokumisa ukuze kuphole. izinga lokushisa lekamelo lokukala.
Ukubala: Ukulahlekelwa ekomisweni %= (M1-M2) ÷M×100
Kuphi: M1: isisindo sesampula nebhodlela lokulinganisa ngaphambi kokoma, amagremu
I-M2: isisindo sesampula kanye nebhodlela lokulinganisa ngemva kokumiswa, ngamagremu
M: Isisindo sesampula, amagremu
5. Ukujikeleza okuqondile
-- Ukuzungeza okuqondile kukalwa ngokuhambisana ne-GB/T613-1988
Ukulungiswa kwesampula: isampula ye-0.5000g yakalwa ngokunembile futhi yayiswa ebhodleleni levolumu ehlanzekile neyomile elingu-50ml, i-DMF engu-20ml yengezwa, ibhodlela lavalwa futhi lanyakaziswa ukuze lincibilike, bese lihlanjululwa esikalini nge-DMF.
Isivivinyo: Lungisa uziro we-gyroscope ngaphambi kokuhlolwa, bese ulayisha ithubhu lokuhlola ngesixazululo sesampula, urekhode i-engeli yokuzungezisa, futhi ubale ukuzungezisa okuthile kwesampula ngefomula elandelayo.
[а]D20=(r×50) ÷ (L×W)
[а]D20: Ukujikeleza okuqondile kokubona ku-25℃ kwesixazululo sesampula
r: Ukuzungezisa okubonwa ku-20℃ ngesixazululo sesampula
50: Umthamo wesixazululo sesampula esilungisiwe (ml)
w: Isisindo sesampula (g)
L: Ubude beshubhu elijikelezayo lokubuka (dm)
Indlela Yokuthenga?Sicela uxhumaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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Izimakethe Eziyinhloko?Thengisa emakethe yasekhaya, eNyakatho Melika, eYurophu, eNdiya, eKorea, eJapane, e-Australia, njll.
Izinzuzo?Ikhwalithi ephezulu, intengo ethengekayo, izinsizakalo ezichwepheshile nokusekelwa kobuchwepheshe, ukulethwa okusheshayo.
IkhwalithiIsiqiniseko?Isistimu yokulawula ikhwalithi eqinile.Imishini yobuchwepheshe yokuhlaziya ifaka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, NOMA, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njll.
Amasampula?Imikhiqizo eminingi inikeza amasampula wamahhala wokuhlolwa kwekhwalithi, izindleko zokuthumela kufanele zikhokhelwe amakhasimende.
Ukuhlolwa Kwemboni?Wamukelekile ekucwaningweni kwemboni.Sicela wenze i-aphoyintimenti kusengaphambili.
I-MOQ?Ayikho i-MOQ.I-oda elincane liyamukeleka.
Isikhathi sokuthumela? Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe.
Ezokuthutha?By Express (FedEx, DHL), by Air, by Sea.
Amadokhumenti?Ngemuva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njll.
Custom Synthesis?Ingahlinzeka ngezinsizakalo zokwenziwa ngokwezifiso ukuze zilingane kangcono nezidingo zakho zocwaningo.
Imigomo Yokukhokha?I-invoyisi ye-Proforma izothunyelwa kuqala ngemva kokuqinisekiswa kwe-oda, kufakwe nemininingwane yethu yasebhange.Inkokhelo nge-T/T (Telex Transfer), PayPal, Western Union, njll.
Izimpawu Zengozi Xi - Iyacasula
Amakhodi Engozi 36/37/38 - Ukucasula amehlo, uhlelo lokuphefumula kanye nesikhumba.
Incazelo Yezokuphepha S22 - Ungaluphefumuli uthuli.
I-S24/25 - Gwema ukuthintana nesikhumba namehlo.
I-S36/37/39 - Gqoka izingubo zokuzivikela ezifanele, amagilavu nokuvikela iso/ubuso.
S27 - Khumula ngokushesha zonke izingubo ezingcolile.
S26 - Uma uthintana namehlo, geza ngokushesha ngamanzi amaningi futhi ufune iseluleko sezokwelapha.
I-WGK Germany 3
I-HS Code 2922491990
I-N-Fmoc-L-Leucine (Fmoc-Leu-OH) (CAS: 35661-60-0) iphuma ku-amino acid engalungiselelwa ukusabela kwe-L-Leucine ne-9-Fluorenomethoxycarbonyl Chloride.
Ama-Fmoc-amino acids, asetshenziswa ku-peptide synthesis, asetshenziswa njenge-organic synthesis intermediate, pharmaceutical intermediate, reagent biochemical noma i-chemical reagent.
I-Fmoc-L-Leu-OH, iphuma ku-amino acid, esetshenziswa kumakhemikhali e-peptide.Ibhulokhi yokwakha ejwayelekile yokwenziwa kwesigaba esiqinile se-peptide kulandela amaqhinga e-Fmoc.Futhi kungenye yenoveli ye-PPARγ ligands engenza i-PPARγ isebenze ngezindlela ezihlukene, enciphisa ukuhlukaniswa kwama-osteoclasts, futhi ngaleyo ndlela ibe okuhloswe kangcono kokwelapha esisifo sikashukela kunezidakamizwa zendabuko ze-antidiabetic.
Ukulungiselela i-1.05g (0.008 mol) i-L-Leucine solid incibilika ku-10% yesisombululo se-sodium carbonate, inyakaziswa ukuze incibilike ngokugcwele i-glycine solid, kanye ne-9-fluorene methoxycarbonyl chloride (2.10g, 0.008 mol) isixazululo esincibilikisiwe ku-toluene (2~205 ml) yengezwa ngokudonsela phansi ku-20 ~ 30 ℃, yehlisa ukwengeza imizuzu engama-30 ~ 60, vala isengezo se-dropwise, gudluza ku-20 ~ 30 ℃ amahora angu-1 ~ 8, engeza u-30-200 ml wamanzi ukuze uhlanjululwe, futhi ukhiphe nge-n-butyl. i-acetate (80 ml) ukuze ikhiphe i-9-fluorene methoxycarbonyl chloride eyeqile, Isigaba se-aqueous esitholiwe sifakwa i-asidi nge-hydrochloric acid egxilile iye ku-PH = 0.5~3.5, bese ikhishwa nge-n-butyl acetate (80 ml), futhi isigaba sikawoyela esitholiwe igezwe ngamanzi ukuze ikhiphe i-hydrochloric acid, isigaba sikawoyela sagxiliswa ukususa i-n-butyl acetate solvent, amakristalu amhlophe ancishiswa, ahlungwa futhi omiswa ukuze kutholwe i-2.46g ye-Nα-9-fluorene methoxycarbonyl-L-leucine, enesivuno esingu-87.0 %.
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