I-Fondaparinux Sodium CAS 114870-03-0 API

Incazelo emfushane:

Igama Lekhemikhali: Fondaparinux Sodium

I-CAS: 114870-03-0

Ukubukeka: Impushana Emhlophe ukuya Emhlophe

I-Assay: 95.0%~103.0% (Kusisekelo Esomisiwe)

I-Antithrombotic Anticoagulant, i-Factor Xa Inhibitor

Thintana: UDkt. Alvin Huang

Iselula/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Imikhiqizo Ehlobene

Omaka bomkhiqizo

Incazelo:

Nikeza Ngokuhlanzeka Okuphezulu kanye Nekhwalithi Ezinzile
Igama Lekhemikhali: Fondaparinux Sodium
I-CAS: 114870-03-0
I-Antithrombotic Anticoagulant, i-Factor Xa Inhibitor
Ikhwalithi ephezulu ye-API, Ukukhiqiza Kwezentengiso

Chemical Properties:

Igama Lekhemikhali	I-Fondaparinux Sodium
Inombolo ye-CAS	114870-03-0
Inombolo yeCAT	I-RF-API84
Isimo Sesitoko	Esitokweni, Isikali Sokukhiqiza Sifika Emakhulwini Amakhilogremu
I-Molecular Formula	I-C31H43N3O49S8.10Na
Isisindo samangqamuzana	1728.08
Ibhrendi	I-Ruifu Chemical

Imininingwane:

Into	Imininingwane
Ukubukeka	Impushana Emhlophe Kuya Kumhlophe
Indlela Yokuhlola / Yokuhlaziya	95.0%~103.0% (ngokomisiwe)
Ukuncibilika	I-Soluble Freely in Water, 2.0M Sodium Chloride kanye ne-0.5M Sodium Hydroxide kanye ne-Insoluble ku-Ethanol
Ukuhlonza 13C-NMR	Ama-resonances we-Fondaparinux Sodium kufanele abonwe ku-58.2, 29.5, 60.5, 60.8, 68.9, 69.2, 69.6, 98.9, 100.4, 101.1, 102.4, 103.9, 103.9, 176.7Ukushintsha kwamakhemikhali kwalezi zimpawu akuhlukani ngaphezu kuka-±0.3ppm ezinye izimpawu zokuphakama okuguquguqukayo nokushintsha kwamakhemikhali, okubangelwa i-Fondaparinux Sodium, okungenzeka kubonakale phakathi kuka-58.0~80.5 ppm no-98.7~104.5ppm.
Ukuhlonza HPLC	Isikhathi sokugcina sesiqongo esikhulu sesixazululo sesampula sihambisana naleso sesixazululo esijwayelekile
Ukuhlonza i-AAS	I-sodium kufanele ibe nokumuncwa kwesici ku-330.2nm ngaphansi kokunqunywa kwe-sodium
pH	6.0~8.0
I-Sodium (Na)	11.5%~15.0% (Ibalwa ku-anhydrous nezincibilikisi mahhala)
I-sulfate yamahhala	≤0.30%
I-Chloride esele	≤1.00%
Izinto Ezihlobene
Ukungcola A	≤0.80%
Ukungcola B	≤0.60%
Okunye Ukungcola Okukodwa	≤0.30%
Ukungcola Okuphelele	≤2.00%
Izincibilikisi Ezisele
I-Methanol	≤3000ppm
I-Ethanol	≤5000ppm
I-Ethyl Acetate	≤5000ppm
I-DMF	≤880ppm
I-methylbenzene	≤890ppm
I-Pyridine	≤50ppm
Okuqukethwe kwamanzi (KF)	≤15.0%
Ama-bacterium Endotoxins	≤3.3EU/mg
Umkhawulo weMicrobial	Isamba senani Lezinto Ezincane ≤100cfu/g
Izinga Lokuhlola	Izinga lebhizinisi;I-United States Pharmacopoeia (USP) Standard
Ukusetshenziswa	I-API, I-Antithrombotic Anticoagulant, i-Factor Xa Inhibitor

Iphakheji nesitoreji:

Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, isigubhu seCardboard, 25kg/Drum, noma ngokwezidingo zekhasimende.

Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni, umswakama kanye nezinambuzane.

Izinzuzo:

I-FAQ:

Isicelo:

I-Fondaparinux Sodium (CAS 114870-03-0) ingeyokuqala ekilasini elisha le-antithrombotic anticoagulant ehlobene ngamakhemikhali ne-low molecular weight heparins (LMWH).I-Fondaparinux sodium iyisici se-factor Xa inhibitor ukwakha indawo ephezulu yokubopha i-anti-coagulant factor antithrombin III (ATIII).Ukubophezela kwe-Fondaparinux sodium kule sayithi kwandisa umphumela wemvelo wokuvimbela we-ATIII ngokumelene ne-factor Xa nge-factory cishe engu-300, okuholela ekuvinjweni kokukhiqizwa kwe-thrombin.Imakethwa ngabakwa-GlaxoSmithKline.Inguqulo ejwayelekile eyakhiwe yi-Alchemia imakethwa ngaphakathi e-US yi-Dr. Reddy's Laboratories.I-Fondaparinux sodium yethulwa okokuqala e-US nge-prophylaxis ye-deep vein thrombosis engaholela embolism yamaphaphu kulandela ukuhlinzwa okukhulu kwamathambo.Le molekyuli yokwenziwa ngokuphelele iyikhophi yokulandelana kwe-heparin pentasaccharide, ucezu olufushane kakhulu olukwazi ukwenza i-antithrombin lllmediated inhibition of factor Xa ngaleyo ndlela ivimbele ukukhiqizwa kwe-thrombin ngaphandle kwesenzo se-antithrombin.