I-Fondaparinux Sodium CAS 114870-03-0 API
Nikeza Ngokuhlanzeka Okuphezulu kanye Nekhwalithi Ezinzile
Igama Lekhemikhali: Fondaparinux Sodium
I-CAS: 114870-03-0
I-Antithrombotic Anticoagulant, i-Factor Xa Inhibitor
Ikhwalithi ephezulu ye-API, Ukukhiqiza Kwezentengiso
Igama Lekhemikhali | I-Fondaparinux Sodium |
Inombolo ye-CAS | 114870-03-0 |
Inombolo yeCAT | I-RF-API84 |
Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifika Emakhulwini Amakhilogremu |
I-Molecular Formula | I-C31H43N3O49S8.10Na |
Isisindo samangqamuzana | 1728.08 |
Ibhrendi | I-Ruifu Chemical |
Into | Imininingwane |
Ukubukeka | Impushana Emhlophe Kuya Kumhlophe |
Indlela Yokuhlola / Yokuhlaziya | 95.0%~103.0% (ngokomisiwe) |
Ukuncibilika | I-Soluble Freely in Water, 2.0M Sodium Chloride kanye ne-0.5M Sodium Hydroxide kanye ne-Insoluble ku-Ethanol |
Ukuhlonza 13C-NMR | Ama-resonances we-Fondaparinux Sodium kufanele abonwe ku-58.2, 29.5, 60.5, 60.8, 68.9, 69.2, 69.6, 98.9, 100.4, 101.1, 102.4, 103.9, 103.9, 176.7Ukushintsha kwamakhemikhali kwalezi zimpawu akuhlukani ngaphezu kuka-±0.3ppm ezinye izimpawu zokuphakama okuguquguqukayo nokushintsha kwamakhemikhali, okubangelwa i-Fondaparinux Sodium, okungenzeka kubonakale phakathi kuka-58.0~80.5 ppm no-98.7~104.5ppm. |
Ukuhlonza HPLC | Isikhathi sokugcina sesiqongo esikhulu sesixazululo sesampula sihambisana naleso sesixazululo esijwayelekile |
Ukuhlonza i-AAS | I-sodium kufanele ibe nokumuncwa kwesici ku-330.2nm ngaphansi kokunqunywa kwe-sodium |
pH | 6.0~8.0 |
I-Sodium (Na) | 11.5%~15.0% (Ibalwa ku-anhydrous nezincibilikisi mahhala) |
I-sulfate yamahhala | ≤0.30% |
I-Chloride esele | ≤1.00% |
Izinto Ezihlobene | |
Ukungcola A | ≤0.80% |
Ukungcola B | ≤0.60% |
Okunye Ukungcola Okukodwa | ≤0.30% |
Ukungcola Okuphelele | ≤2.00% |
Izincibilikisi Ezisele | |
I-Methanol | ≤3000ppm |
I-Ethanol | ≤5000ppm |
I-Ethyl Acetate | ≤5000ppm |
I-DMF | ≤880ppm |
I-methylbenzene | ≤890ppm |
I-Pyridine | ≤50ppm |
Okuqukethwe kwamanzi (KF) | ≤15.0% |
Ama-bacterium Endotoxins | ≤3.3EU/mg |
Umkhawulo weMicrobial | Isamba senani Lezinto Ezincane ≤100cfu/g |
Izinga Lokuhlola | Izinga lebhizinisi;I-United States Pharmacopoeia (USP) Standard |
Ukusetshenziswa | I-API, I-Antithrombotic Anticoagulant, i-Factor Xa Inhibitor |
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, isigubhu seCardboard, 25kg/Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni, umswakama kanye nezinambuzane.
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I-Fondaparinux Sodium (CAS 114870-03-0) ingeyokuqala ekilasini elisha le-antithrombotic anticoagulant ehlobene ngamakhemikhali ne-low molecular weight heparins (LMWH).I-Fondaparinux sodium iyisici se-factor Xa inhibitor ukwakha indawo ephezulu yokubopha i-anti-coagulant factor antithrombin III (ATIII).Ukubophezela kwe-Fondaparinux sodium kule sayithi kwandisa umphumela wemvelo wokuvimbela we-ATIII ngokumelene ne-factor Xa nge-factory cishe engu-300, okuholela ekuvinjweni kokukhiqizwa kwe-thrombin.Imakethwa ngabakwa-GlaxoSmithKline.Inguqulo ejwayelekile eyakhiwe yi-Alchemia imakethwa ngaphakathi e-US yi-Dr. Reddy's Laboratories.I-Fondaparinux sodium yethulwa okokuqala e-US nge-prophylaxis ye-deep vein thrombosis engaholela embolism yamaphaphu kulandela ukuhlinzwa okukhulu kwamathambo.Le molekyuli yokwenziwa ngokuphelele iyikhophi yokulandelana kwe-heparin pentasaccharide, ucezu olufushane kakhulu olukwazi ukwenza i-antithrombin lllmediated inhibition of factor Xa ngaleyo ndlela ivimbele ukukhiqizwa kwe-thrombin ngaphandle kwesenzo se-antithrombin.
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