I-Fulvestrant (ICI 182780) CAS 129453-61-8 API Factory High Quality

Incazelo emfushane:

Igama: Fulvestrant (ICI 182780)

I-CAS: 129453-61-8

Ukubukeka: I-Crystalline Powder Emhlophe ukuya Kokumhlophe

I-Assay: 97.0% ~ 102.0% (ngokomisiwe)

I-Fulvestrant isetshenziswa ekwelapheni umdlavuza webele othuthukisiwe ozwela i-hormone kwabesifazane be-postmenopausal.

Ikhwalithi ephezulu ye-API, Ukukhiqiza Kwezentengiso

Inquiry: alvin@ruifuchem.com

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Incazelo:

Ukunikezela Komkhiqizi Ngokuhlanzeka Okuphezulu kanye Nekhwalithi Ezinzile
Igama: Fulvestrant
I-CAS: 129453-61-8
I-Fulvestrant isetshenziswa ekwelapheni umdlavuza webele othuthukisiwe ozwela i-hormone kwabesifazane be-postmenopausal.
Ikhwalithi ephezulu ye-API, Ukukhiqiza Kwezentengiso

Chemical Properties:

Igama Lekhemikhali	I-Fulvestrant
Omqondofana	(7α,17β)-7-[9-[(4,4,5,5,5-Pentafluorpentyl)sulfinyl]nonyl]estra-1,3,5(10)-trien-3,17-diol;I-ICI 182780
Inombolo ye-CAS	129453-61-8
Inombolo yeCAT	I-RF-API81
Isimo Sesitoko	Esitokweni, Isikali Sokukhiqiza Sifika Emakhulwini Amakhilogremu
I-Molecular Formula	I-C32H47F5O3S
Isisindo samangqamuzana	606.77
I-Melting Point	104.0 ~ 106.0℃
Ukuncibilika	I-Soluble ku-Methanol, i-Ethanol;Ayincibiliki Emanzini
Ibhrendi	I-Ruifu Chemical

Imininingwane:

Into	Imininingwane
Ukubukeka	I-Crystalline Powder emhlophe ukuya kokumhlophe
Ukuhlonza	Nge-IR, HPLC
I-Specific Optical Rotation	+108.0° ukuze +115.0°
Ukulahlekelwa Ekumisweni	≤0.50%
Izinsalela ekushiseni	≤0.10%
I-6-Keto-Fulvestrant	≤0.10%
6,7-Fulvestrant	≤0.10%
I-Fulvestrant Sulfone	≤0.20%
I-Fulvestrant Yandisiwe	≤0.30%
I-Fulvestrant sterol Dimmer	≤0.80%
Noma Ikuphi Ukungcola Komuntu Ngamunye Okungashiwongo	≤0.10%
Ukungcola Okuphelele	≤1.0%
Fulvestrant A	42.0%~48.0%
UFulvestrant B	52.0%~58.0%
I-DMF	≤620ppm
Izinsimbi Ezisindayo	≤10ppm
Isivivinyo	97.0%~102.0% (ngokomisiwe)
Isitoreji	Londoloza esitolo seziqukathi ezikwazi ukumelana nokukhanya ezivaleke kahle futhi esiqandisini esingu-2~8℃
Izinga Lokuhlola	I-United States Pharmacopoeia (USP) Standard
Ukusetshenziswa	I-Estrogen Receptor Antagonist

Iphakheji nesitoreji:

Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, isigubhu seCardboard, 25kg/Drum, noma ngokwezidingo zekhasimende.

Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni, umswakama kanye nezinambuzane.

Izinzuzo:

I-FAQ:

Isicelo:

I-Fulvestrant (ICI-182780) I-CAS 129453-61-8, iyisidakamizwa sokujova imisipha esakhiwe yinkampani i-AstraZeneca futhi sisetshenziswa ekwelapheni umdlavuza webele othuthukisiwe ozwela i-hormone kwabesifazane be-postmenopausal.I-Fulvestrant ukuphela kwesidakamizwa se-antiestrogen esingasetshenziswa kabanzi emtholampilo ngemva kokwelashwa kwe-tamoxifen okungaphumelelanga.Lo muthi uwuhlobo lokwelapha lwe-endocrine, ngakho-ke ngeke ubangele noma yimiphi imiphumela emibi evame ukubonwa ekwelapheni ngamakhemikhali, okuwunikeza ukuthobela kwesiguli okuhle kakhulu.Izivivinyo eziningi zemitholampilo zithole ukuthi i-250mg Fulvestrant iyasebenza futhi iphephile ngokungaguquki njengomugqa wesibili wokwelashwa komdlavuza webele othuthukile.I-Fulvestrant iyi-synthetic Estrogen Receptor (ER) Umphikisi one-IC50 ka-0.94 nM ekuhlolweni okungenamaseli.I-Fulvestrant iphinde ifake i-autophagy ne-apoptosis futhi inomsebenzi we-antitumor.