I-Ganciclovir CAS 82410-32-0 API BW 759 GCV Antiviral CMV Inhibitor High Quality
Ukunikezela Komkhiqizi Ngokuhlanzeka Okuphezulu kanye Nekhwalithi Ezinzile
Igama Lekhemikhali: Ganciclovir
I-CAS: 82410-32-0
I-Agent ye-Antiviral yokwelashwa kwe-Cytomegalovirus (CMV) Infection
Ikhwalithi ephezulu ye-API, Ukukhiqiza Kwezentengiso
Igama Lekhemikhali | I-Ganciclovir |
Omqondofana | I-GCV;BW 759;9-[[2-Hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine;I-2-Amino-9- (1,3-dihydroxypropan-2-yloxymethyl) -3H-purin-6-one;2'-Nor-2'-Deoxyguanosine |
Inombolo ye-CAS | 82410-32-0 |
Inombolo yeCAT | I-RF-API82 |
Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani |
I-Molecular Formula | I-C9H13N5O4 |
Isisindo samangqamuzana | 255.23 |
I-Melting Point | 250 ℃ |
Izinga Lokushisa Lesitoreji | 2-8℃ |
Ibhrendi | I-Ruifu Chemical |
Into | Imininingwane |
Ukubukeka | I-Crystalline Powder emhlophe ukuya kokumhlophe |
Ukuncibilika | Incibilika Kancane Emanzini |
Ukuhlonza | Ukumuncwa kwe-Ultraviolet, ukumuncwa kwe-infrared |
Ukulahlekelwa Ekumisweni | ≤6.0% |
Izinsalela ekushiseni | ≤0.10% |
Izinto Ezihlobene | I-Ganciclovir Related Compound A ≤0.50% |
Umkhawulo we-Guanine | ≤0.50% |
I-Residual Solvents (GC) | I-Ethanol ≤5000ppm |
Izinsimbi Ezisindayo | ≤10ppm |
I-Absorption Coefficient | 516-548 ku-252nm |
Ama-bacterium Endotoxins | ≤0.84EU/mg |
Isivivinyo | 98.0%~102.0% (I-Titration) |
Izinga Lokuhlola | Izinga lebhizinisi;I-United States Pharmacopoeia (USP) Standard |
Ukusetshenziswa | I-API, i-CMV Inhibitor |
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, isigubhu seCardboard, 25kg/Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni, umswakama kanye nezinambuzane.
I-Ganciclovir (CAS 82410-32-0) ingeyemithi elwa namagciwane e-nucleoside, iwuhlobo lokuphuma kwe-guanosine.I-Ganciclovir iyi-ejenti ye-antiviral esebenzayo kubazali ekhonjelwe izifo ezisongela impilo ze-cytomegalovirus (CMV) ezigulini ezingenawo amandla omzimba.Ine-spectrum ebanzi, imiphumela esebenza kahle kakhulu yokuvimbela igciwane le-herpes futhi iyisidakamizwa esikhethwa kuqala sokwelapha ukutheleleka kwe-cytomegalovirus nomthelela oqinile kugciwane le-hepatitis B kanye ne-adenovirus futhi.Kuyi-homologue ye-acyclovir (ACV) nomphumela wayo we-antiviral ofana, kodwa unamandla kune-aciclovir, enemiphumela enamandla ikakhulukazi evimbela i-cytomegalovirus ehambisana neziguli ze-AIDS.Isetshenziswa emtholampilo ekwelapheni isigaba sokungeniswa kanye nesigaba sokunakekela ezigulini ezingenawo amandla omzimba (kuhlanganise neziguli ezine-AIDS) ezine-cytomegalovirus retinitis.Ingasetshenziselwa futhi ukuvimbela isifo se-cytomegalovirus ezigulini ezithola ukufakelwa kwezitho noma iziguli ze-AIDS ezinemiphumela emihle ekuhlolweni kwe-cytomegalovirus serology.
I-Ganciclovir (CAS 82410-32-0) iyi-inhibitor yegciwane esebenza kahle kakhulu, enobuthi obuphansi futhi ekhetheke kakhulu eyakhiwe yiNkampani ye-Syntex (United States).Umuthi wokuqala ogunyazwe yi-FDA yase-US ekwelapheni ukutheleleka nge-cytomegalovirus (CMV).I-Syntex inikezwe ilungelo elikhethekile lokukhiqiza.NgoJuni 1988, le thebhulethi yagunyazwa okokuqala ngqa ukuthi ifakwe ohlwini e-UK, kulandele ukugunyazwa ngokulandelana yi-France, i-United States, i-Japan, ne-West Germany, i-Italy ne-Canada namanye amazwe.Kuze kube sekupheleni kukaJuni 1999, sekuvunyelwe emazweni angaphezu kuka-70 nasezifundeni zokuvimbela iziguli ezinesifo sokuzivikela komzimba kanye nokutheleleka kwe-cytomegalovirus yeziguli zokufakelwa kwezitho zomzimba.Ngo-2002, amaphilisi e-Ganciclovir athole imvume ye-FDA, aseyatholakala manje.