I-Gemcitabine CAS 95058-81-4 Assay 98.0~102.0%

Incazelo emfushane:

Igama Lekhemikhali: Gemcitabine

I-CAS: 95058-81-4

Isilinganiso: 98.0 ~ 102.0%

I-Crystalline Powder Emhlophe noma Cishe Emhlophe, Ayinaphunga

Thintana: UDkt. Alvin Huang

Iselula/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Imikhiqizo Ehlobene

Omaka bomkhiqizo

95058-81-4 - Incazelo:

I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi ohamba phambili we-Gemcitabine (CAS: 95058-81-4) enekhwalithi ephezulu.I-Ruifu Chemical inganikeza ukulethwa komhlaba wonke, intengo encintisanayo, isevisi enhle kakhulu, amanani amancane kanye nenqwaba etholakalayo.Thenga iGemcitabine,Please contact: alvin@ruifuchem.com

95058-81-4 - Izakhiwo Zamakhemikhali:

Igama Lekhemikhali	Gemcitabine
Omqondofana	2'-Deoxy-2',2'-Difluorocytidine;4-Amino-1-[3,3-Difluoro-4-Hydroxy-5-(Hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;I-dFDC;Gemzar (Lilly);I-LY-188011;dFdCyd;I-DDFC;2',2'-Difluoro-2'-deoxycytidine;2',2'-Difluorodeoxycytidine;I-Folfugem;I-GemLip;Gemcel;I-Gamcitabine
Isimo Sesitoko	Esitokweni, Amandla Okukhiqiza Amathani angu-5
Inombolo ye-CAS	95058-81-4
I-CAS ehlobene	122111-03-9
I-Molecular Formula	I-C9H11F2N3O4
Isisindo samangqamuzana	263.20 g/mol
I-Melting Point	217.0 ukuze 222.0℃
Ukuminyana	1.84±0.10 g/cm3
Kuyazwela	Ukushisa Kuyazwela
Ukuncibilika kwamanzi	Ayincibiliki Emanzini
I-COA ne-MSDS	Iyatholakala
Umsuka	Shanghai, China
Ibhrendi	I-Ruifu Chemical

95058-81-4 - Imininingwane:

Izinto	Imininingwane	Imiphumela
Ukubukeka	I-Crystalline Powder Emhlophe noma Cishe Emhlophe, Ayinaphunga	Iyahambisana
I-Cytosine	≤0.10%	0.002%
α-Isomer	≤0.10%	0.01%
Ukungcola Ngamunye	≤0.10%	0.03%
Ukungcola Okuphelele	≤1.00%	0.10%
Amanzi nguKarl Fischer	≤1.00%	0.67%
Ukuzungezisa okuqondile	+68.0°~+74.0°	+70.5°
Izinsimbi Ezisindayo	≤10ppm	<10ppm
Izinsalela ekushiseni	≤0.10%	0.03%
I-Assay (Nge-HPLC)	98.0%~102.0%	99.9%
I-Infrared Spectrum	Ihambisana Nesakhiwo	Iyahambisana
1H NMR Spectrum	Ihambisana Nesakhiwo	Iyahambisana
Isiphetho	Umkhiqizo uhloliwe futhi uthobela imininingwane enikeziwe

Iphakheji/Isitoreji/Ukuthumela ngomkhumbi:

Iphakheji:Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina isitsha sivalwe ngokuqinile futhi usigcine endaweni epholile, eyomile futhi enomoya omuhle kude nezinto ezingahambelani.Gwema ukuchayeka elangeni eliqondile, umswakama kanye nokushisa ngokweqile.
Ukuthumela:Zilethe emhlabeni wonke ngendiza, yi-FedEx/DHL Express.Nikeza ukulethwa okusheshayo nokuthembekile.

Izinzuzo:

Amandla Anele: Izinsiza ezanele kanye nochwepheshe

Isevisi Yobuchwepheshe: Isevisi yokuthenga yokuma eyodwa

Iphakheji le-OEM: Iphakheji yangokwezifiso kanye nelebula iyatholakala

Ukulethwa Okusheshayo: Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe

Impahla Ezinzile: Gcina isitoko esinengqondo

Ukusekelwa Kwezobuchwepheshe: Isixazululo sezobuchwepheshe siyatholakala

Isevisi Yokuhlanganisa Ngokwezifiso: Isukela kumagremu kuye kumakhilo

Ikhwalithi Ephezulu: Kusungulwe uhlelo oluphelele lokuqinisekisa ikhwalithi

I-FAQ:

Indlela Yokuthenga?Sicela uxhumaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

Iminyaka engu-15 Yokuhlangenwe nakho?Sinesipiliyoni seminyaka engaphezu kwe-15 ekwakhiweni nasekuthumeleni kwamanye amazwe uhla olubanzi lwezinga eliphezulu lokuxhumanisa imithi noma amakhemikhali amahle.

Izimakethe Eziyinhloko?Thengisa emakethe yasekhaya, eNyakatho Melika, eYurophu, eNdiya, eKorea, eJapane, e-Australia, njll.

Izinzuzo?Ikhwalithi ephezulu, intengo ethengekayo, izinsizakalo ezichwepheshile nokusekelwa kobuchwepheshe, ukulethwa okusheshayo.

IkhwalithiIsiqiniseko?Isistimu yokulawula ikhwalithi eqinile.Imishini yobuchwepheshe yokuhlaziya ifaka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, NOMA, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njll.

Amasampula?Imikhiqizo eminingi inikeza amasampula wamahhala wokuhlolwa kwekhwalithi, izindleko zokuthumela kufanele zikhokhelwe amakhasimende.

Ukuhlolwa Kwemboni?Wamukelekile ekucwaningweni kwemboni.Sicela wenze i-aphoyintimenti kusengaphambili.

I-MOQ?Ayikho i-MOQ.I-oda elincane liyamukeleka.

Isikhathi sokuthumela? Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe.

Ezokuthutha?By Express (FedEx, DHL), by Air, by Sea.

Amadokhumenti?Ngemuva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njll.

Custom Synthesis?Ingahlinzeka ngezinsizakalo zokwenziwa ngokwezifiso ukuze zilingane kangcono nezidingo zakho zocwaningo.

Imigomo Yokukhokha?I-invoyisi ye-Proforma izothunyelwa kuqala ngemva kokuqinisekiswa kwe-oda, kufakwe nemininingwane yethu yasebhange.Inkokhelo nge-T/T (Telex Transfer), PayPal, Western Union, njll.

95058-81-4 - Ubungozi Nokuphepha:

Amakhodi Engozi R21 - Kuyingozi ukuthintana nesikhumba
R36/38 - Ukucasula emehlweni nasesikhumbeni.
R46 - Ingadala ukulimala kofuzo
I-R62 - Ingozi engaba khona yokukhubazeka kokuzala
R63 - Ingozi engaba khona yokulimala enganeni engakazalwa
Incazelo Yezokuphepha S25 - Gwema ukuthintana namehlo.
S26 - Uma uthintana namehlo, geza ngokushesha ngamanzi amaningi futhi ufune iseluleko sezokwelapha.
I-S36/37 - Gqoka izingubo zokuzivikela ezifanele namagilavu.
I-S53 - Gwema ukuchayeka - thola imiyalelo ekhethekile ngaphambi kokusetshenziswa.
I-HS Code 2934999091
Ubuthi be-LD10 iv kumagundane: 200 mg/m2 (Abbruzzese)

95058-81-4 - Isicelo:

I-Gemcitabine (CAS: 95058-81-4) umuthi we-chemotherapy osetshenziselwa ukwelapha izinhlobo eziningi zomdlavuza.Lokhu kuhlanganisa umdlavuza webele, umdlavuza wamaphaphu ongewona omncane, umdlavuza wamaphaphu, umdlavuza wesinye, nomdlavuza wamaphaphu.I-Gemcitabine iyaphenywa ukuze isetshenziswe kumdlavuza womminzo, futhi isetshenziswa ngokuhlola kuma-lymphomas nezinye izinhlobo zamathumba.I-Gemcitabine ilawulwa umzila we-intravenous, ngoba i-metabolized kakhulu yi-gastrointestinal tract.
I-Gemcitabine iyi-analogue ye-nucleotide, eyingxenye yezidakamizwa ezilwa nomdlavuza.Isebenza kakhulu ku-DNA synthesis phase, okungukuthi, isigaba S.Ngaphansi kwezimo ezithile, ingavimbela isigaba se-G1 ukuthi sithuthukele esigabeni sika-S.Inezici ze-spectrum ebanzi ye-anticancer, indlela eyingqayizivele yokwenza, ubuthi obuphansi, ayinakho ukumelana nezinye izidakamizwa ze-chemotherapy futhi ayinayo ubuthi obuphezulu.I-Chemicalbook, i-gemcitabine, manje isigunyazwe ukuthi isetshenziswe emazweni angaphezu kuka-90, okuyenza ibe umugqa wokuqala wokwelapha umdlavuza wamaphaphu wengqamuzana ongewona omncane kanye "nezinga legolide" lomdlavuza we-pancreatic.
Ngo-1999, i-CFDA igunyaze i-gemcitabine yokwelashwa kwe-NSCLC ethuthukisiwe yasendaweni noma ye-metastatic, umdlavuza we-pancreatic othuthukisiwe wasendaweni noma we-metastatic;Ngo-2010, i-CChemicalbookFDA yagunyaza i-gemcitabine ngokuhlanganiswa ne-paclitaxel yokwelashwa komdlavuza webele ongasahleki, ophindelela endaweni noma we-metastatic ophinde wavela ngemva kwe-adjuvant/neoadjuvant chemotherapy.
I-Gemcitabine iyi-antimetabolite ene-spectrum ebanzi ne-analogue ye-deoxycytidine enomsebenzi we-antineoplastic.Lapho isetshenziswa, i-gemcitabine iguqulwa ibe i-metabolites esebenzayo i-difluorodeoxycytidine diphosphate (dFdCDP) kanye ne-difluorodeoxycytidine triphosphate (dFdCTP) nge-deoxycytidine kinase.I-dFdCTP iqhudelana ne-deoxycytidine triphosphate (dCTP) futhi ifakwe ku-DNA.Lokhu kukhiya i-DNA polymerase ngaleyo ndlela kuholele ekunqanyulweni okufihliwe ngesikhathi sokuphindaphinda kwe-DNA.Ngakolunye uhlangothi, i-dFdCDP ivimbela i-ribonucleotide reductase, ngaleyo ndlela yehlise i-deoxynucleotide pool etholakalayo yokuhlanganiswa kwe-DNA.Ukuncipha kokuhlushwa kwe-intracellular ye-dCTP kunamandla okufakwa kwe-dFdCTP ku-DNA.