I-Guanfacine Hydrochloride I-Guanfacine HCl CAS 29110-48-3 API USP Standard High Purity
Umkhiqizi onokuhlanzeka Okuphezulu kanye Nekhwalithi Ezinzile
Igama Lekhemikhali: I-Guanfacine Hydrochloride
Synonym: Guanfacine HCl
I-CAS: 29110-48-3
I-Guanfacine Hydrochloride iyi-agonist ekhethiwe ye-α2A-adrenoceptor.I-Antihypertensive
Ikhwalithi ephezulu ye-API, Ukukhiqiza Kwezentengiso
Igama Lekhemikhali | I-Guanfacine Hydrochloride |
Omqondofana | I-Guanfacine HCl |
Inombolo ye-CAS | 29110-48-3 |
Inombolo yeCAT | I-RF-API40 |
Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani |
I-Molecular Formula | I-C9H10Cl3N3O |
Isisindo samangqamuzana | 282.55 |
I-Melting Point | 211.0~215.0℃ |
Ibhrendi | I-Ruifu Chemical |
Into | Imininingwane |
Ukubukeka | I-Crystalline Powder emhlophe ukuya kokumhlophe |
Ukuhlonza | Ukumuncwa kwe-infrared;I-HPLC |
Ukulahlekelwa Ekumisweni | ≤0.50% |
Izinsalela ekushiseni | ≤0.10% |
Izinsimbi Ezisindayo | ≤20ppm |
Isivivinyo | 98.0%~102.0% (HPLC ngokomisiwe) |
I-Chromatographic Purity | ≥99.0% |
Izinga Lokuhlola | I-USP Standard |
Ukusetshenziswa | I-Active Pharmaceutical Ingredient (API) |
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, isigubhu seCardboard, 25kg/Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni, umswakama kanye nezinambuzane.
I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi oholayo nomphakeli we-Guanfacine Hydrochloride (CAS: 29110-48-3) enekhwalithi ephezulu.
I-Guanfacine hydrochloride emaphakathi ebamba i-adrenoceptor agonist.I-Antihypertensive.I-Guanfacine hydrochloride, i-ejenti elwa nomfutho wegazi ophezulu, iyi-agonist ekhethiwe ye-α2A-adrenoceptor ene-Kd engu-31 nM futhi ibonisa ukukhetha okuphindwe izikhathi ezingu-60 ngaphezu kwe-α2B-adrenoceptors.I-Guanfacine yehlisa kokubili umfutho wegazi we-systolic kanye ne-diastolic ngokwenza kusebenze isimiso sezinzwa esimaphakathi i-α2A norepinephrine autoreceptors, okuholela ekuncipheni kokuphuma kozwela kwe-peripheral futhi ngaleyo ndlela kunciphe ithoni yokuzwelana ne-peripheral.Izicelo zokwelapha ze-guanfacine ziyefana nalezo zamanye ama-agonists e-α2-adrenergic amaphakathi ne-methyldopa.Isebenze njenge-monotherapy ekwelapheni iziguli ezinomfutho wegazi ophakeme omaphakathi kuya komaphakathi.