H-Gly-OMe·HCl CAS 5680-79-5 Glycine Methyl Ester Hydrochloride Assay >99.0%

1. Izakhiwo: Lo mkhiqizo kufanele ube yimpushana ecwebezelayo emhlophe.
2. Isivivinyo:
1) Ukunqunywa kwe-Glycine Methyl Ester Hydrochloride assay
1.1 Indlela
Ngaphansi kwezimo ezine-acidic, isampula isabela ngenani elithile le-nitrate esiliva, futhi i-nitrate esiliva eyeqile ibuyiselwa nge-ammonium thiocyanate, ibhekisela ku-ammonium ferric sulfate.
Njengenkomba, ingqikithi yokuqukethwe kwe-chlorine yanqunywa ngokuya ngevolumu yesisombululo esijwayelekile esisetshenzisiwe, futhi inani le-chlorine eliphelele lakhishwa kokuqukethwe kwe-glycine hydrochloride ukuze kutholwe okuqukethwe kwe-Glycine Methyl Ester Hydrochloride.
1.2 Ama-reagents
i-dibutyl phthalate;
Isixazululo se-nitric acid: 2+3;
Isixazululo esijwayelekile se-nitrate yesiliva: c(AgNO3) = 0.1 mol/L
Isixazululo setitration esijwayelekile se-Ammonium thiocyanate: c(NH4SCN) = 0.1 mol/L
I-Ammonium ferric sulfate (III) inkomba yoketshezi: 80 g/L
1.3 Inqubo Yokuhlaziya
Isisindo sesampula esingaba ngu-0.5g, esinembile sibe ngu-0.0001g.Faka ku-250ml ye-conical flask, ncibilikisa emanzini angu-40ml, engeza isixazululo se-nitric acid engu-10 ml, Engeza (50 ± 0.02) mL silver nitrate standard titration solution, 3mL ammonium ferric sulfate indicator solution, 4mL dibutyl phthalate, kanye ne-thiocyanate standard titration solution i-titrated kuze kube yilapho isixazululo sinsundu ngokukhanyayo futhi sihlala singenambala imizuzwana engama-30.
1.4 Ukubalwa kwemiphumela
Ingxenye enkulu yokuqukethwe kwe-glycine methyl ester hydrochloric acid w1, evezwa njenge-%, ibalwa ngokuvumelana ne-Equation (1):
w1= (c1V1-c2V2)*M/1000/m * 100-w2 *1.126 ifomula (1)
Kuphi:
I-V1: Ivolumu yesisombululo esijwayelekile se-nitrate yesiliva (ml)
I-V2: Ivolumu yesisombululo se-titration se-ammonium thiocyanate esidliwe yi-titration (ml)
c1: Inani eliqondile lesixazululo esijwayelekile se-nitrate yesiliva (mol/L)
c2: Inani eliqondile lesisombululo setitration esijwayelekile se-ammonium thiocyanate (mol/L)
w2: Ingxenyana enkulu (%) yokuqukethwe kwe-glycine hydrochloride njengoba kunqunywe eSigabeni 4.2
M: I-molar mass ye-glycine methyl ester hydrochloride (g/mol)
1.126: Ukuguqulwa kwe-coefficient ye-glycine hydrochloride kuya ku-Glycine methyl ester hydrochloride.
Inani lesilinganiso se-arithmetic lemiphumela emibili yokulinganisa ehambisanayo lithathwe njengomphumela wokulinganisa, futhi umehluko ophelele phakathi kwemiphumela yokulinganisa emibili ehambisanayo wawungekho ngaphezu kuka-0.05%.
2) Ukunqunywa kokuqukethwe kwe-glycine hydrochloride
2.1 Indlela
Kusetshenziswa i-dimethyl ephuzi njengenkomba, isampula yafakwa isixazululo se-sodium hydroxide standard titrating, futhi umthamo wesixazululo wancishiswa ngokuya ngokusetshenziswa kwezinga le-sodium hydroxide.
Bala okuqukethwe kwe-glycine hydrochloride.
2.2 I-Reagent
Isixazululo esijwayelekile se-titration ye-sodium hydroxide: c (NaOH) = 0.1mol/L
I-Dimethyl yellow inkomba liquid: 10 g/L
2.3 Inqubo Yokuhlaziya
Kala cishe isampula laselabhorethri elingu-5.0 g, elinembile libe ngu-0.0001g, libe ebhekhani elingu-200 ml, ncibilikisa ngamanzi angu-50ml, bese wengeza amaconsi angu-5 e-dimethyl.
Uketshezi oluyinkomba oluphuzi, olune-sodium hydroxide standard titration solution titration kuze kube yilapho ikhambi elisuka kokubomvu ukuya kokuphuzi lifika ekugcineni.
2.4 Ukubalwa kwemiphumela
Ingxenye enkulu engu-w2 yokuqukethwe kwe-glycine hydrochloride ichazwa njenge-% futhi ibalwa ngokuvumelana ne-Equation (2):
w2 =(V/1000)cM/m *100 ifomula (2)
Kuphi:
V: Umthamo wesodium hydroxide standard titration solution (mL)
c: Inani eliqondile le-sodium hydroxide standard titration solution (mol/L)
M: I-molar mass ye-glycine hydrochloride (g/mol)
m: Inani elikhulu lesampula (g)
Inani lesilinganiso se-arithmetic lemiphumela emibili yokulinganisa ehambisanayo lithathwe njengomphumela wokulinganisa, futhi umehluko ophelele phakathi kwemiphumela yokulinganisa emibili ehambisanayo wawungekho ngaphezu kuka-0.05%
3. Iphuzu lokuncibilika: Ngokwendlela yokunqunywa kwendawo yokuncibilika (i-Chinese Pharmacopoeia 2010 Appendix VIC), ibanga lephoyinti lokuncibilika lingu-172-178 ºC.
4. Ukomisa ukwehla kwesisindo: thatha lo mkhiqizo ku-105.0℃ futhi uyomise ukuze ube nesisindo esingaguquki.Ukuncipha kwesisindo akufanele kudlule i-0.5%.
5. Isitoreji: Lo mkhiqizo kufanele ufakwe efrijini kude nokukhanya.