I-Histamine Dihydrochloride CAS 56-92-8 Assay 98.5~101.0% (Titration) Factory
I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi oholayo kanye nomphakeli we-Histamine Dihydrochloride (CAS: 56-92-8) enekhwalithi ephezulu.Impahla eluhlazaL-Histidine (H-His-OH) (CAS: 71-00-1)Singahlinzeka ngokudiliva emhlabeni wonke, amanani amancane futhi ngobuningi atholakalayo.Uma unentshisekelo ku-Histamine Dihydrochloride,Please contact: alvin@ruifuchem.com
| Igama Lekhemikhali | I-Histamine Dihydrochloride |
| Omqondofana | I-histamine 2HCl;I-Histamine DiHCl;2-(4-Imidazolyl) ethylamine Dihydrochloride;I-2-(1H-Imidazol-4-yl) i-ethylamine Dihydrochloride;I-2-(1H-Imidazol-4-yl) i-ethylamine Dihydrochloride;I-1H-Imidazole-4-ethanamine Dihydrochloride;I-Ceplene;Peremin |
| Isimo Sesitoko | Esitokweni, Amandla Okukhiqiza Amathani angama-20 ngenyanga |
| Inombolo ye-CAS | 56-92-8 |
| I-Molecular Formula | C5H9N3·2HCl |
| Isisindo samangqamuzana | 184.06 |
| I-Melting Point | 247.0~249.0℃(lit.) |
| Ukuminyana | 1.14 |
| Kuyazwela | I-Hygroscopic |
| Ukuncibilika kwamanzi | Incibilika Ngokuphelele Emanzini, Icishe Ikhanye |
| Ukuncibilika | I-Soluble Kakhulu ku-Methanol, I-Soluble ku-Ethanol, Ayincibiliki ku-Ether |
| Isikhathi Sokugcina. | Ivalwe Komile, Isitolo Emazingeni Okushisa Egumbi |
| I-COA ne-MSDS | Iyatholakala |
| Ibhrendi | I-Ruifu Chemical |
| Amakhodi Wengozi | Xn,Xi | I-RTECS | MS1575000 |
| Izitatimende Zobungozi | 36/37/38-42/43-42-22 | F | 1-8-9 |
| Izitatimende Zokuphepha | 22-26-36/37/39-45-37-36/37 | I-TSCA | Yebo |
| I-RIDADR | 3335 | I-Hazard Class | Iyacasula |
| I-WGK Germany | 2 | Ikhodi ye-HS | 2933990099 |
| Izinto | Amazinga Wokuhlola | Imiphumela |
| Ukubukeka | Amakristalu Amhlophe noma I-Crystalline Powder | Kuyavumelana |
| Ukuhlonza | I-Infrared Absorption Spectrum | Kuyavumelana |
| Ukubukeka Kwesixazululo | Kucace | Dlula |
| I-Histidine (TLC) | Angatholwa | Kuyavumelana |
| I-Sulfate (SO4) | ≤0.020% | <0.020% |
| Insimbi (Fe) | ≤10ppm | <10ppm |
| Izinsimbi Ezisindayo (Pb) | ≤10ppm | <10ppm |
| I-Arsenic (As2O3) | ≤10ppm | <10ppm |
| Ukulahlekelwa Ekumisweni | ≤0.50% | 0.24% |
| I-Sulfated Ash | ≤0.20% | 0.06% |
| Isivivinyo | 98.5 kuya ku-101.0% (nge-Titration) | 99.36% |
| Inani le-pH | 2.85 kuya ku-3.60 (10% aq. Isixazululo) | 3.16 |
| Isiphetho | Ivumelana Nezinga le-AJI97, EP9.0 | |
| Ukusetshenziswa Okuyinhloko | Ama-amino Acids;Izithasiselo Zokudla;Pharmaceutical Intermediates | |
Impahla Engavuthiwe kanye Nezincibilikisi Ezibandakanyeka Enqubweni Yokuhlanganiswa
Ama-Raw material:
L-Histidine (H-His-OH) CAS 71-00-1
I-Acetophenone CAS 98-86-2
I-Hydrochloric Acid CAS 7647-01-0
Izincibilikisi
I-Diethylene Glycol CAS 111-46-6
I-Ethanol CAS 64-17-5
I-Isopropyl Alcohol CAS 67-63-0
Amanzi
I-Histamine Dihydrochloride (CAS: 56-92-8) EP9.0 Indlela Yokuhlola IvolumuⅡ
INCAZELO
I-Histamine dihydrochloride iqukethe amaphesenti angekho ngaphansi kwamaphesenti angama-98.5 futhi angekho ngaphezu kokulingana namaphesenti angu-101.0 we-2-(1H-imidazol-4-yl) ethan-1-amine dihydrochloride, ebalwa ngokubhekisela entweni eyomisiwe.
ABALINGISI
Impushana emhlophe noma ecishe ibe mhlophe, icrystalline noma amakristalu angenambala, i-hygroscopic, encibilika kakhulu emanzini, encibilika otshwaleni.
UKUKHOMBA
Umazisi wokuqala: A, D.
Ukuhlonza okwesibili: B, C, D
A. Hlola nge-infrared absorption spectrophotometry (2.2.24), uqhathanisa ne-spectrum etholwe nge-histamine dihydrochloride CRS.Hlola njengamadiski alungiselelwe usebenzisa i-1 mg yezinto.
B. Hlola ama-chromatogram atholwe ekuhlolweni kwe-histidine.Indawo eyinhloko kuchromatogram etholwe ngesixazululo sokuhlola (b) iyafana ngokuma, umbala nosayizi nendawo eyinhloko kuchromatogram etholwe ngesixazululo sereferensi (a).
C. Chaza u-0.1 g ku-7 mL wamanzi R bese wengeza u-3 mL wesisombululo esingu-200 g/L se-sodium hydroxide R. Chaza u-50mg we-sulfanilic acid R kwinhlanganisela engu-0.1 mL we-hydrochloric acid R no-10 mL wamanzi R kanye engeza u-0.1 mL wesisombululo se-sodium nitrite R. Faka isixazululo sesibili kwesokuqala bese uxuba.Kukhiqizwa umbala obomvu.
D. Inikeza ukusabela (a) kwe-chlorides (2.3.1).
IZIVIVINYO
Isixazululo S. Chaza i-0.5g emanzini angenayo i-carbon dioxide R elungiselelwe emanzini acwengekile R bese unciphisa ku-10 mL nge-solvent efanayo.
Ukubukeka kwesixazululo.Isixazululo S sicacile (2.2.1) futhi asinawo umbala ogqamile kunesixazululo esingu-Y7 (2.2.2, Indlela II).
pH (2.2.3).I-pH yesisombululo S ingu-2.85 kuya ku-3.60.
I-Histidine.Hlola nge-chromatography yongqimba oluncane (2.2.27), usebenzisa i-TLC silica gel G plate R.
Isixazululo sokuhlola (a).Chaza u-0.5g wento ezohlolwa emanzini R bese unciphisa ibe ngu-10 mL ngesincibilikisi esifanayo.
Isixazululo sokuhlola (b).Nciphisa u-2 mL wesisombululo sokuhlola (a) kuya ku-10 mL ngamanzi R.
Isixazululo sereferensi (a).Chaza u-0.1 g we-histamine dihydrochloride CRS emanzini R bese uncibilikisa ku-10 mL ngesincibilikisi esifanayo.
Isixazululo sereferensi (b).Chaza u-50 mg we-histidine monohydrochloride R emanzini R futhi uhlambulule ube ngu-100 mL nge-solvent efanayo.
Isixazululo sereferensi (c).Hlanganisa i-1 ml yesisombululo sokuhlola (a) kanye ne-1 mL yesisombululo sereferensi (b).
Faka epuletini elingu-1 μL lesixazululo sokuhlola (a), 1 μL yesixazululo sokuhlola (b), 1 μL yesisombululo sereferensi (a), 1 μL yesixazululo sereferensi (b) kanye no-2 μL wesixazululo sereferensi (c).Yakha ngendlela engu-15cm usebenzisa ingxube yamavolumu angu-5 e-ammonia R egxilile, imiqulu engama-20 yamanzi R kanye namavolumu angama-75 e-acetonitrile R. Yomisa ipuleti emoyeni wamanje.Phinda ukuthuthukiswa ngendlela efanayo, yomisa ipuleti endaweni yomoya bese ufafaza ngesisombululo se-ninhydrin R1.Shisisa ipuleti ku-110 ° C imizuzu eyi-10.Noma iyiphi indawo ehambisana ne-histidine ku-chromatogram etholwe ngesixazululo sokuhlola (a) ayishubi ngaphezu kwendawo eku-chromatogram etholwe ngesixazululo sereferensi (b) (iphesenti elingu-1).Ukuhlola akuvumelekile ngaphandle kwalapho ichromatogram etholwe nesixazululo sereferensi (c) ikhombisa izindawo ezi-2 ezihlukaniswe ngokucacile.
Ama-sulfate (2.4.13).I-3mL yesisombululo S ehlanjululwe ku-15 mL ngamanzi acwecwe R ithobelana nokuhlolwa komkhawulo wama-sulfate (0.1 amaphesenti).
Ukulahlekelwa ekumisweni (2.2.32).Kungabi ngaphezu kwamaphesenti angu-0.5, okunqunywa ku-0.20 g ngokomisa kuhhavini ku-105 °C.
Umlotha ofakwe emanzini (2.4.14).Hhayi ngaphezu kwamaphesenti angu-0.1, anqunywe ku-0.5 g.
ISIVIVINYO
Chaza u-0.080 g kwinhlanganisela engu-5.0 mL ka-0.01 M hydrochloric acid no-50 mL wotshwala R. Yenza i-titration ye-potentiometric (2.2.20), usebenzisa i-0.1 M sodium hydroxide.Funda ivolumu eyengezwe phakathi kwephuzu lokuqala nelesithathu lokuguquguquka.
I-1mL ka-0.1 M i-sodium hydroxide ilingana no-9.203 mg we-C5H11Cl2N3.
ISITOREJI
Gcina esitsheni esingangeni moya, esivikelwe ekukhanyeni.
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Ukusetshenziswa kwe-Histamine Dihydrochloride (CAS: 56-92-8)
1. I-Histamine Dihydrochloride iboniswe ukuthi ivule i-nitric oxide synthetase futhi icindezele noma ivimbele ukukhiqizwa kwezinhlobo ze-oxygen esebenzayo (ROS).Ukuvinjelwa kwe-ROS nge-Histamine Dihydrochloride kuvumela ukusebenza kwamaseli e-T namaseli e-NK nge-IL-2.Kumodeli yegundane, i-histamine dihydrochloride icindezele i-ROS ekhiqizwe amaseli e-Kupffer nge-H2 histamine receptor.Kuyi-vasodilator enamandla kanye ne-endogenous histamine receptor agonist.
2. I-Histamine Dihydrochloride (igama lokuhweba i-Ceplene) usawoti we-Histamine osetshenziswa njengesidakamizwa sokuvimbela ukuphindeka ezigulini ezitholakala zine-acute myeloid leukemia (AML).
Kuyisithako esisebenzayo esigunyazwe yi-FDA sokusetshenziswa kwe-analgesic yangaphakathi futhi itholakala emikhiqizweni efana ne-Australian Dream Cream, esetshenziselwa ukukhulula izinhlungu ezincane zemisipha namalunga ahambisana nesifo samathambo, iqolo elilula, imihuzuko, ukukruneka, kanye izinhlungu.
3. I-Histamine Dihydrochloride isetshenziselwa ukuxolelwa okuqhubekayo kanye nokuvimbela ukuphindeka ezigulini ezikhulile ezine-acute myeloid leukemia (AML) elandela ukwelashwa kokuqala kokuxolelwa.Umuthi unciphisa ukukhiqizwa kwamaqembu omoya-mpilo ngama-autophagocyte, uvimbela i-nicotinamide adenine dichemicalbo phosphate oxidase futhi uvimbela i-interleukin-2 ekwenzeni kusebenze amaseli e-NK nama-T cell.Umjovo we-Histamine Dihydrochloride wavunywa ngesisekelo sokuthi ukukhululwa kwawo okuphelele kuhlanganiswe ne-interleukin-2 kunciphisa kakhulu ukuphindeka ezigulini ze-AML.
