N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS 152460-10-1 Imatinib Mesylate Intermediate High Purity
Ukunikezwa Kwezohwebo I-Imatinib Mesylate kanye Nezixhumanisi Ezihlobene:
I-Imatinib Mesylate CAS: 220127-57-1
N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine CAS: 152460-09-8
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS: 152460-10-1
4--[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride CAS: 106261-49-8
| Igama Lekhemikhali | N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea |
| Omqondofana | I-Imatinib Mesylate Intermediate;2-(5-Amino-2-methylanilino)-4-(3-pyridyl)pyrimidine |
| Inombolo ye-CAS | 152460-10-1 |
| Inombolo yeCAT | I-RF-PI230 |
| Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani |
| I-Molecular Formula | I-C16H15N5 |
| Isisindo samangqamuzana | 277.32 |
| I-Melting Point | 133.0-135.0℃ |
| Ibhrendi | I-Ruifu Chemical |
| Into | Imininingwane |
| Ukubukeka | Okuwolintshi Okukhanyayo kuya Kumpushana Ophuzi kuya kuCrystal |
| Ukuhlanzeka / Indlela Yokuhlaziya | ≥98.0% |
| Ukulahlekelwa Ekumisweni | ≤0.50% |
| Izinsalela ekushiseni | ≤0.50% |
| Ukungcola Okuphelele | ≤2.0% |
| Ukungcola Okukodwa Okukhulu | ≤1.0% |
| Izinsimbi Ezisindayo | ≤20ppm |
| Izinga Lokuhlola | I-Enterprise Standard |
| Ukusetshenziswa | Okumaphakathi kwe-Imatinib Mesylate (CAS: 220127-57-1) |
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, isigubhu seCardboard, 25kg/Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni, umswakama kanye nezinambuzane.
I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi oholayo nomnikezeli we-N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea (CAS: 152460-10-1) enekhwalithi ephezulu .
I-N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea (CAS: 152460-10-1) iyisimaphakathi ngokuvamile ekuhlanganisweni kwe-Imatinib Mesylate (CAS: 220127-57-1 ) I-API.
I-Imatinib mesylate iyi-molecule encane evimbela i-c-Abl protein-tyrosine kinase, i-kinase ebaluleke ngokukhethekile ekwandeni kwe-chronic myelogenous leukemia (CML).Umcimbi wokuthutha phakathi kwama-chromosome 9 kanye no-22 ukhiqiza i-chromosome yase-Philadelphia, ebese ikhiqiza iphrotheni ye-Bcr-Abl fusion enomsebenzi we-aberrant kinase okhuthaza ukwanda okusheshayo kwamaseli.I-Imatinib mesylate ihlanganisa le kinase ebalulekile, imisa ukukhula okuhlobene ne-CML.I-Imatinib mesylate iphinde yaboniswa ukuze ivimbele i-PDGFR kanye ne-tyrosine kinases ehlotshaniswa ne-c-Kit.Amafomula aqukethe i-Imatinib mesylate asetshenziswe ekwelapheni umdlavuza ohlukahlukene.
I-Imatinib mesylate iyi-tyrosine kinase inhibitor.Iqonde kakhulu i-BCR-ABL, i-enzyme ehlotshaniswa ne-chronic myelogenous leukemia (CML) kanye nezinhlobo ezithile ze-acute lymphoblastic leukemia (ALL).I-v-Abl tyrosine kinase inhibitor enamandla futhi ekhethayo (IC50 = 38 nM).Iphinde ivimbele i-PDGFR ne-c-kit.Ibonisa ukukhetha kwe-v-Abl phezu kwephaneli enye i-tyrosine ne-serine/threonine protein kinases.Ngokukhethekile ivimbela ukukhula okukhuthazwa yi-PDGF kwamaseli e-PB-3 aguqulelwe yi-v-abl kanye namaseli e-V-sis-transformed BALB/c 3T3 in vitro.Ibonisa imiphumela ye-antitumor kumagundane aphethe i-AMuLV noma i-BABL/c 3T3 v-sis cell.Ivimbela ukuphindaphinda kwe-SARS-CoV ne-MERS-CoV in vitro (amanani e-EC50 angu-9.823 kanye no-17.689 μM, ngokulandelanayo).
![4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride CAS 106261-49-8 Imatinib Mesylate Intermediate High Purity](https://www.ruifuchemical.com/uploads/d1fa2a19-300x300.jpg)