I-Imatinib Mesylate CAS 220127-57-1 Assay 98.0%~102.0% Ph+CML API Factory High Quality
Ukunikezwa Kwezohwebo I-Imatinib Mesylate kanye Nezixhumanisi Ezihlobene:
I-Imatinib Mesylate CAS: 220127-57-1
N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine CAS: 152460-09-8
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS: 152460-10-1
4--[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride CAS: 106261-49-8
Igama Lekhemikhali | I-Imatinib Mesylate (ifomu le-alpha) |
Omqondofana | I-Imatinib Methanesulfonate;I-STI571 Mesylate;I-CGP-57148B |
Inombolo ye-CAS | 220127-57-1 |
Inombolo yeCAT | I-RF-API19 |
Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani |
I-Molecular Formula | I-C30H35N7O4S |
Isisindo samangqamuzana | 589.71 |
Isimo Sokuthumela | Ngaphansi Kwezinga Lokushisa Le-Ambient |
Ibhrendi | I-Ruifu Chemical |
Into | Imininingwane |
Ukubukeka | I-Crystalline Powder emhlophe ukuya kokumhlophe |
Ukuncibilika | Kulula ukuncibilika emanzini |
I-HPLC Identification | Isikhathi sokugcinwa kwesilinganiso esiphezulu sesampula sihambisana nalokho |
Ubunikazi be-IR | I-spectrum yokumuncwa kwe-infrared yesampula ihambisana nesampula yereferensi |
I-Melting Point | 214.0~222.0℃ |
Ukulahlekelwa Ekumisweni | ≤0.50% |
Izinsalela ekushiseni | ≤0.10% |
Izinsimbi Ezisindayo | ≤20ppm |
Izinto Ezihlobene | (1) Ukungcola G: NMT 0.3% |
(2) Ukungcola B: NMT 0.3% | |
(3) Ukungcola C: NMT 0.3% | |
(4) Ukungcola D: NMT 0.3% | |
(5) Ukungcola A: NMT 0.3% | |
(6) Ukungcola H: NMT 0.3% | |
(7) Ukungcola F: NMT 0.3% | |
(8) Ukungcola E: NMT 0.3% | |
(9) Ukungcola okukodwa okukhulu kakhulu: NMT0.1% | |
Izincibilikisi Ezisele | (1) I-Ethyl Acetate: NMT 5000ppm |
(2) I-Methanol: NMT3000ppm | |
(3) I-Dichloromethane: NMT 600ppm | |
(4) I-Ethanol: NMT 5000ppm | |
(5) I-Toluene: NMT 890ppm | |
(6) I-Dimethyl Sulfoxide: NMT5000ppm | |
Ukuhlolwa kwe-HPLC | 98.0%~102.0% (C30H35N7SO4 Ibalwa Ngesisekelo Esingenamanzi) |
Izinga Lokuhlola | I-Enterprise Standard |
Ukusetshenziswa | I-API;I-Ph+CML |
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, isigubhu seCardboard, 25kg/Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni, umswakama kanye nezinambuzane.
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I-Imatinib Mesylate(CAS 220127-57-1) iyingqamuzana encane evimbela i-c-Abl protein-tyrosine kinase, i-kinase ebaluleke ngokukhethekile ekwandeni kwe-chronic myelogenous leukemia (CML).Iqonde kakhulu i-BCR-ABL, i-enzyme ehlotshaniswa ne-chronic myelogenous leukemia (CML) kanye nezinhlobo ezithile ze-acute lymphoblastic leukemia (ALL).I-v-Abl tyrosine kinase inhibitor enamandla futhi ekhethayo (IC50 = 38 nM).Umcimbi wokuthutha phakathi kwama-chromosome 9 kanye no-22 ukhiqiza i-chromosome yase-Philadelphia, ebese ikhiqiza iphrotheni ye-Bcr-Abl fusion enomsebenzi we-aberrant kinase okhuthaza ukwanda okusheshayo kwamaseli.I-Imatinib mesylate ihlanganisa le kinase ebalulekile, imisa ukukhula okuhlobene ne-CML.I-Imatinib mesylate iphinde yaboniswa ukuze ivimbele i-PDGFR kanye ne-tyrosine kinases ehlotshaniswa ne-c-Kit.