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I-Imatinib Mesylate CAS 220127-57-1 Assay 98.0%~102.0% Ph+CML API Factory High Quality Image Factory
  • I-Imatinib Mesylate CAS 220127-57-1 Assay 98.0%~102.0% Ph+CML API Factory High Quality

I-Imatinib Mesylate CAS 220127-57-1 Assay 98.0%~102.0% Ph+CML API Factory High Quality

Incazelo emfushane:

Igama Lekhemikhali: I-Imatinib Mesylate (ifomu le-alpha)

I-CAS: 220127-57-1

Ukubukeka: I-Crystalline Powder Emhlophe ukuya Kokumhlophe

I-HPLC Assay: 98.0%~102.0%

I-Imatinib Mesylate ekwelapheni i-Philadelphia Chromosome-Positive Chronic Myeloid Leukemia (Ph+CML)

Ikhwalithi ephezulu ye-API, Ukukhiqiza Kwezentengiso

Inquiry: alvin@ruifuchem.com


Imininingwane Yomkhiqizo

Imikhiqizo Ehlobene

Omaka bomkhiqizo

Incazelo:

Ukunikezwa Kwezohwebo I-Imatinib Mesylate kanye Nezixhumanisi Ezihlobene:
I-Imatinib Mesylate CAS: 220127-57-1
N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine CAS: 152460-09-8
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS: 152460-10-1
4--[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride CAS: 106261-49-8

Chemical Properties:

Igama Lekhemikhali I-Imatinib Mesylate (ifomu le-alpha)
Omqondofana I-Imatinib Methanesulfonate;I-STI571 Mesylate;I-CGP-57148B
Inombolo ye-CAS 220127-57-1
Inombolo yeCAT I-RF-API19
Isimo Sesitoko Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani
I-Molecular Formula I-C30H35N7O4S
Isisindo samangqamuzana 589.71
Isimo Sokuthumela Ngaphansi Kwezinga Lokushisa Le-Ambient
Ibhrendi I-Ruifu Chemical

Imininingwane:

Into Imininingwane
Ukubukeka I-Crystalline Powder emhlophe ukuya kokumhlophe
Ukuncibilika Kulula ukuncibilika emanzini
I-HPLC Identification Isikhathi sokugcinwa kwesilinganiso esiphezulu sesampula sihambisana nalokho
Ubunikazi be-IR I-spectrum yokumuncwa kwe-infrared yesampula ihambisana nesampula yereferensi
I-Melting Point 214.0~222.0℃
Ukulahlekelwa Ekumisweni ≤0.50%
Izinsalela ekushiseni ≤0.10%
Izinsimbi Ezisindayo ≤20ppm
Izinto Ezihlobene (1) Ukungcola G: NMT 0.3%
(2) Ukungcola B: NMT 0.3%
(3) Ukungcola C: NMT 0.3%
(4) Ukungcola D: NMT 0.3%
(5) Ukungcola A: NMT 0.3%
(6) Ukungcola H: NMT 0.3%
(7) Ukungcola F: NMT 0.3%
(8) Ukungcola E: NMT 0.3%
(9) Ukungcola okukodwa okukhulu kakhulu: NMT0.1%
Izincibilikisi Ezisele (1) I-Ethyl Acetate: NMT 5000ppm
(2) I-Methanol: NMT3000ppm
(3) I-Dichloromethane: NMT 600ppm
(4) I-Ethanol: NMT 5000ppm
(5) I-Toluene: NMT 890ppm
(6) I-Dimethyl Sulfoxide: NMT5000ppm
Ukuhlolwa kwe-HPLC 98.0%~102.0% (C30H35N7SO4 Ibalwa Ngesisekelo Esingenamanzi)
Izinga Lokuhlola I-Enterprise Standard
Ukusetshenziswa I-API;I-Ph+CML

Iphakheji nesitoreji:

Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, isigubhu seCardboard, 25kg/Drum, noma ngokwezidingo zekhasimende.

Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni, umswakama kanye nezinambuzane.

Izinzuzo:

1

I-FAQ:

Isicelo:

I-Imatinib Mesylate(CAS 220127-57-1) iyingqamuzana encane evimbela i-c-Abl protein-tyrosine kinase, i-kinase ebaluleke ngokukhethekile ekwandeni kwe-chronic myelogenous leukemia (CML).Iqonde kakhulu i-BCR-ABL, i-enzyme ehlotshaniswa ne-chronic myelogenous leukemia (CML) kanye nezinhlobo ezithile ze-acute lymphoblastic leukemia (ALL).I-v-Abl tyrosine kinase inhibitor enamandla futhi ekhethayo (IC50 = 38 nM).Umcimbi wokuthutha phakathi kwama-chromosome 9 kanye no-22 ukhiqiza i-chromosome yase-Philadelphia, ebese ikhiqiza iphrotheni ye-Bcr-Abl fusion enomsebenzi we-aberrant kinase okhuthaza ukwanda okusheshayo kwamaseli.I-Imatinib mesylate ihlanganisa le kinase ebalulekile, imisa ukukhula okuhlobene ne-CML.I-Imatinib mesylate iphinde yaboniswa ukuze ivimbele i-PDGFR kanye ne-tyrosine kinases ehlotshaniswa ne-c-Kit.

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