I-Irinotecan Hydrochloride CAS 100286-90-6 Purity ≥99.0% (HPLC) API USP Standard High Purity
Umkhiqizi Uhlinzeka Nge-Irinotecan kanye Nezixhumanisi Ezihlobene:
I-Irinotecan Hydrochloride CAS: 100286-90-6
I-Irinotecan Free Base CAS: 97682-44-5
I-Irinotecan Hydrochloride Trihydrate CAS: 136572-09-3
I-7-Ethyl-10-Hydroxycamptothecin CAS: 86639-52-3
I-1-Chlorocarbonyl-4-Piperidinopiperidine Hydrochloride CAS: 143254-82-4
| Igama Lekhemikhali | I-Irinotecan Hydrochloride |
| Omqondofana | I-Camptothecin II;I-CPT-II |
| Inombolo ye-CAS | 100286-90-6 |
| Inombolo yeCAT | I-RF-API50 |
| Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani |
| I-Molecular Formula | I-C33H39ClN4O6 |
| Isisindo samangqamuzana | 623.15 |
| I-Melting Point | 250-256 ℃ (dec.) |
| Izimo Zokugcina | Ngaphansi Kwezinga Lokushisa Le-Ambient |
| Ibhrendi | I-Ruifu Chemical |
| Into | Imininingwane |
| Ukubukeka | Impushana Emhlophe noma Engamhlophe |
| Ukuncibilika | Incibilika emanzini ne-methanol, inyibilika kancane ku-chloroform, i-ethanol |
| Ukuhlonza IR | I-spectrum yokumuncwa kwe-infrared yesampula yokuhlola kufanele ihambisane naleyo yezinga eliyisethenjwa |
| Ukuhlonza HPLC | Isikhathi sokugcinwa kwesilinganiso esiphezulu sesixazululo sesampula kufanele sihambisane naleso sezinga lesithenjwa. |
| Ukuhlonza | Ihlangabezana nezimfuneko zokuhlolwa kwe-Chloride Positive reaction |
| Umswakama (KF) | 7.0%~9.0% w/w |
| Izinsalela ekushiseni | ≤0.10% |
| Izinsimbi Ezisindayo | ≤20ppm |
| I-Irinotecan Hydrochloride Enantiomer | ≤0.10% (HPLC) |
| 7-Desethyl Irinotecan | ≤0.15% |
| I-Irinotecan Related Compound A | ≤0.15% |
| 11-Ethyl Irinotecan | ≤0.15% |
| I-Camptothecin | ≤0.15% |
| I-Irinotecan Related Compound B | ≤0.15% |
| 7-Ethylcanptothecin | ≤0.15% |
| 7,11-Diethyl-10-Hydroxy Camptothecin | ≤0.15% |
| Noma Ikuphi Ukungcola Okungashiwongo | ≤0.10% |
| Ukungcola Okuphelele | ≤0.50% |
| I-Residual Solvents (GC) | |
| I-Methanol | ≤2000ppm |
| I-acetone | ≤2000ppm |
| I-Dichloromethane | ≤500ppm |
| I-Peteoleum Ether: | ≤100ppm |
| I-Ethyl Acetate | ≤2000ppm |
| Benzeni | ≤2ppm |
| Ama-bacterium Endotoxins | ≤0.29 EU/mg Irinotecan |
| Imikhawulo yeMicrobial | Isamba Sesibalo Se-Aerobic Microbial: <1000 cfu/g |
| Isikhunta kanye Nemvubelo | <100 cfu/g |
| Ukuhlanzeka / Indlela Yokuhlaziya | ≥99.0% (HPLC, kusisekelo se-anhydrous) |
| Izinga Lokuhlola | I-United States Pharmacopeia (USP) Standard |
| Ukusetshenziswa | I-Active Pharmaceutical Ingredient (API) |
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, isigubhu seCardboard, 25kg/Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni, umswakama kanye nezinambuzane.
I-lrinotecan hydrochloride (i-CAS 100286-90-6), i-semi-synthetic, esuselwe emanzini e-anticancer agent enamandla i-camptothecin, yethulwa e-Japan ukuze zelashwe umdlavuza wamaphaphu, wesibeletho, nowomlomo wesibeletho.I-lrinotecan yenza umsebenzi wayo we-antitumor ngokuvimbela i-topoisomerase I, i-enzyme yeselula ehilelekile ekugcineni ukwakheka kwendawo ye-DNA phakathi nenqubo yokuhumusha, ukuloba, kanye ne-mitosis.I-lrinotecan yenza i-de-esterification ku-vivo ukuze ikhiqize i-metabolite esebenzayo, i-SN-38, enamandla ngokuphindwe ka-1000 kunomzali.Ukwelashwa okuhlanganisiwe kwe-irinotecan nenye i-ejenti yokulwa nomdlavuza esetshenziswa kakhulu, i-cisplatin, kubikwe ukuthi ingcono kune-ejenti yodwa.I-lrinotecan isesivivinyweni somtholampilo sesisu, ibele, isikhumba, i-colorectal, umdlavuza we-pancreatic, i-mesothelioma kanye ne-non-Hodgkin's lymphoma.
