I-Irinotecan Hydrochloride Trihydrate CAS 136572-09-3 API Factory High Purity
Umkhiqizi Uhlinzeka Nge-Irinotecan kanye Nezixhumanisi Ezihlobene:
I-Irinotecan Hydrochloride CAS: 100286-90-6
I-Irinotecan Free Base CAS: 97682-44-5
I-Irinotecan Hydrochloride Trihydrate CAS: 136572-09-3
I-7-Ethyl-10-Hydroxycamptothecin CAS: 86639-52-3
I-1-Chlorocarbonyl-4-Piperidinopiperidine Hydrochloride CAS: 143254-82-4
| Igama Lekhemikhali | I-Irinotecan Hydrochloride Trihydrate |
| Omqondofana | I-Irinotecan HCl Trihydrate;I-CPT-11 Trihydrate;I-Irinotecan HCL 3H2O |
| Inombolo ye-CAS | 136572-09-3 |
| Inombolo yeCAT | I-RF-API52 |
| Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani |
| I-Molecular Formula | C33H38N4O6·HCl·3H2O |
| Isisindo samangqamuzana | 677.20 |
| I-Melting Point | 250.0~256.0℃ (dec.) |
| Ibhrendi | I-Ruifu Chemical |
| Into | Imininingwane |
| Ukubukeka | I-Crystalline Powder Ephuzi Ekhanyayo noma Ephuzi |
| I-Assay (w/w) | 98.0%~102.0% |
| Ubumsulwa (HPLC) | ≥99.5% |
| Ukuncibilika | Incibilika kancane emanzini, i-ethanol noma i-chloroform, Ayincibiliki ku-acetone |
| Ukuhlonza | nge-IR kanye ne-HPLC, Conforms |
| I-Specific Optical Rotation | +60°~+73° |
| Amanzi | 7.0%~9.0% |
| Izinsalela Zezincibilikisi | Ithobelana Nezimfuneko ze-ICH |
| Izinsalela ekushiseni | ≤0.20% |
| I-Chloride | 5.0%~6.0% |
| Inani le-pH | 3.0~5.0 |
| Izinsimbi Ezisindayo | ≤20ppm |
| Ukungcola Ngamunye | ≤0.10% |
| Ukungcola Okuphelele | ≤0.50% |
| Isimo Sesitoreji | Gcina ku-2-8 ° C, Ezitsheni ezivaliwe futhi uvikele ekukhanyeni nasemswakama |
| Izinga Lokuhlola | I-Enterprise Standard |
| Ukusetshenziswa | I-Active Pharmaceutical Ingredient (API) |
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, isigubhu seCardboard, 25kg/Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni, umswakama kanye nezinambuzane.
I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi oholayo kanye nomphakeli we-Irinotecan Hydrochloride Trihydrate (CAS: 136572-09-3) enekhwalithi ephezulu.
I-Irinotecan Hydrochloride Trihydrate iyi-topoisomerase I inhibitor esetshenziselwa ikakhulukazi ukwelapha umdlavuza wekoloni kanye nomdlavuza we-rectal, ukuvimbela ukuthembela kwe-DNA strand ngokubophezela ku-topoisomerase I-DNA complex.I-lrinotecan hydrochloride, i-semi-synthetic, ephuma emanzini encibilikayo ye-ejenti enamandla yokulwa nomdlavuza i-camptothecin, yethulwa e-Japan ukuze zelashwe umdlavuza wamaphaphu, wesibeletho, nowomlomo wesibeletho.I-lrinotecan yenza umsebenzi wayo we-antitumor ngokuvimbela i-topoisomerase I, i-enzyme yeselula ehilelekile ekugcineni ukwakheka kwendawo ye-DNA phakathi nenqubo yokuhumusha, ukuloba, kanye ne-mitosis.I-lrinotecan yenza i-de-esterification ku-vivo ukuze ikhiqize i-metabolite esebenzayo, i-SN-38, enamandla ngokuphindwe ka-1000 kunomzali.Nakuba inobuthi obuncane kakhulu kune-camptothecin, inani elibalulekile leziguli ezivivinyweni zomtholampilo labonisa imiphumela engemihle ye-leukopenia, isifo sohudo, isicanucanu, kanye ne-alopecia.Ukwelashwa okuhlanganisiwe kwe-irinotecan nenye i-ejenti yokulwa nomdlavuza esetshenziswa kakhulu, i-cisplatin, kubikwe ukuthi ingcono kune-ejenti yodwa.I-lrinotecan isesivivinyweni somtholampilo sesisu, ibele, isikhumba, i-colorectal, umdlavuza we-pancreatic, i-mesothelioma kanye ne-non-Hodgkin's lymphoma.
