I-Ketorolac Tromethamine CAS 74103-07-4 Ubumsulwa >99.0% (HPLC)

Incazelo emfushane:

Igama Lekhemikhali: Ketorolac Tromethamine

Synonym: Ketorolac Tris Usawoti

I-CAS: 74103-07-4

Ubumsulwa: >99.0% (HPLC) (T)

Ukubukeka: I-Crystalline Powder Emhlophe ukuya Kokumhlophe

Thintana: UDkt. Alvin Huang

Iselula/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


Imininingwane Yomkhiqizo

Imikhiqizo Ehlobene

Omaka bomkhiqizo

Incazelo:

I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi ohamba phambili kanye nomphakeli we-Ketorolac Tromethamine Salt (CAS: 74103-07-4) enekhwalithi ephezulu.Singahlinzeka nge-COA, ukulethwa komhlaba wonke, amanani amancane kanye nenqwaba etholakalayo.Uma unentshisekelo kulo mkhiqizo, sicela uthumele imininingwane enemininingwane ehlanganisa inombolo ye-CAS, igama lomkhiqizo, nenani kithi.Please contact: alvin@ruifuchem.com

Chemical Properties:

Igama Lekhemikhali I-Ketorolac Tromethamine
Omqondofana I-Ketorolac Tris Usawoti;I-Ketorolac (Tromethamine Salt);rac Ketorolac Tromethamine Usawoti;Toradol;(±)-5-Benzoyl-2,3-Dihydro-1H-Pyrrolizine-1-Carboxylic Acid Tris Usawoti;(±) -Ifomu le-Tromethamine Usawoti
Inombolo ye-CAS 74103-07-4
Isimo Sesitoko Esitokweni, Kwenzelwe Ukuthengisa
I-Molecular Formula C15H13NO3·C4H11NO3
Isisindo samangqamuzana 376.41
I-Melting Point 160.0~161.0℃
Iphuzu elibilayo 493.2℃ ku-760 mmHg
Kuyazwela I-Hygroscopic.Ukukhanya Okuzwelayo
λ ubuningi 322nm(MeOH)(lit.)
I-COA ne-MSDS Iyatholakala
Ibhrendi I-Ruifu Chemical

Imininingwane:

Into Imininingwane
Ukubukeka I-Crystalline Powder emhlophe ukuya kokumhlophe
pH 5.7~6.7
I-Melting Point 160.0~161.0℃
Ukuhlanzeka / Indlela Yokuhlaziya >99.0% (HPLC)
Indlela Yokuhlola / Yokuhlaziya 98.5~101.5% (Ibalwe Ngesisekelo Esomile)
Ukulahlekelwa Ekumisweni <0.50%
Izinsalela ekushiseni <0.10%
Izinsimbi Ezisindayo (Pb) ≤20ppm
Izinto Ezihlobene
Ukungcola RRT0.54 <0.50%
Ukungcola RRT0.66 <0.50%
I-Ketorolac 1-Keto Analog <0.10%
I-Ketorolac 1-Hydroxy Analog <0.10%
Noma Ikuphi Okunye Ukungcola Okukodwa <0.20%
Ukungcola Okuphelele <1.00%
Izincibilikisi Ezisele
I-Dichloroethane <50ppm
I-Ethanol engenamanzi <5000ppm
Imikhawulo ye-Microorganism
Amagciwane Inani <1000cfu/g
Isikhunta Nemvubelo Inani <100cfu/g
I-Escherichia.Coli Akekho
I-Endotoxin yebhaktheriya <5EU/mg
I-Infrared Spectrum Ivumelana Nesakhiwo
I-Solubility ku-H2O Okungenambala kuya Kufifi Kuphuzi Kucace (15 mg/ml) Dlula
Izinga Lokuhlola I-Enterprise Standard

Iphakheji nesitoreji:

Iphakheji:Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina esitsheni esivalwe ngci.Gcina endaweni epholile, eyomile (2~8℃) futhi enomoya omuhle kude nezinto ezingahambelani.Vikela ekukhanyeni nakumswakama.
Ukuthumela:Zilethe emhlabeni wonke ngendiza, yi-FedEx/DHL Express.Nikeza ukulethwa okusheshayo nokuthembekile.

Izinzuzo:

Amandla Anele: Izinsiza ezanele kanye nochwepheshe

Isevisi Yobuchwepheshe: Isevisi yokuthenga yokuma eyodwa

Iphakheji le-OEM: Iphakheji yangokwezifiso kanye nelebula iyatholakala

Ukulethwa Okusheshayo: Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe

Impahla Ezinzile: Gcina isitoko esinengqondo

Ukusekelwa Kwezobuchwepheshe: Isixazululo sezobuchwepheshe siyatholakala

Isevisi Yokuhlanganisa Ngokwezifiso: Isukela kumagremu kuye kumakhilo

Ikhwalithi Ephezulu: Kusungulwe uhlelo oluphelele lokuqinisekisa ikhwalithi

I-FAQ:

Indlela Yokuthenga?Sicela uxhumaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

Iminyaka engu-15 Yokuhlangenwe nakho?Sinesipiliyoni seminyaka engaphezu kwe-15 ekwakhiweni nasekuthumeleni kwamanye amazwe uhla olubanzi lwezinga eliphezulu lokuxhumanisa imithi noma amakhemikhali amahle.

Izimakethe Eziyinhloko?Thengisa emakethe yasekhaya, eNyakatho Melika, eYurophu, eNdiya, eKorea, eJapane, e-Australia, njll.

Izinzuzo?Ikhwalithi ephezulu, intengo ethengekayo, izinsizakalo ezichwepheshile nokusekelwa kobuchwepheshe, ukulethwa okusheshayo.

IkhwalithiIsiqiniseko?Isistimu yokulawula ikhwalithi eqinile.Imishini yobuchwepheshe yokuhlaziya ifaka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, NOMA, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njll.

Amasampula?Imikhiqizo eminingi inikeza amasampula wamahhala wokuhlolwa kwekhwalithi, izindleko zokuthumela kufanele zikhokhelwe amakhasimende.

Ukuhlolwa Kwemboni?Wamukelekile ekucwaningweni kwemboni.Sicela wenze i-aphoyintimenti kusengaphambili.

I-MOQ?Ayikho i-MOQ.I-oda elincane liyamukeleka.

Isikhathi sokuthumela? Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe.

Ezokuthutha?By Express (FedEx, DHL), by Air, by Sea.

Amadokhumenti?Ngemuva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njll.

Custom Synthesis?Ingahlinzeka ngezinsizakalo zokwenziwa ngokwezifiso ukuze zilingane kangcono nezidingo zakho zocwaningo.

Imigomo Yokukhokha?I-invoyisi ye-Proforma izothunyelwa kuqala ngemva kokuqinisekiswa kwe-oda, kufakwe nemininingwane yethu yasebhange.Inkokhelo nge-T/T (Telex Transfer), PayPal, Western Union, njll.

Isicelo:

I-Ketorolac Tromethamine Salt (CAS: 74103-07-4) iyi-ejenti engeyona i-steroidal elwa nokuvuvukala ebonisa umsebenzi we-analgesic kanye ne-antipyretic.Kuyi-COX inhibitor engakhethi ene-IC50s ye-20 nM kokubili i-COX-1 ne-COX-2.I-Ketorolac Tromethamine Usawoti iyasebenza ekulawulweni kobuhlungu obumaphakathi kuya kobunzima bangemva kokuhlinzwa.Nokho, ingeyokuqala yalolu hlobo lwe-ejenti okufanele inikezwe abazali njenge-analgesic futhi ikhonjiswe ngokukhethekile ngomjovo we-intramuscular.I-Ketorolac imelela enye indlela ewusizo yama-narcotic analgesics ngenxa yokuntula kwayo ukuhlukumeza.Isetshenziswa ngokuyinhloko emiphumeleni yayo ye-analgesic yokwelashwa kwesikhashana kobuhlungu obuncane kuya kobumaphakathi ezinjeni namagundane.Ubude besikhathi somphumela we-analgesic ezinjeni cishe amahora angu-8-12, kodwa ngenxa yokutholakala kwama-NSAID ezinja agunyaziwe, aphephile, ukusetshenziswa kwawo kuyangabazeka.Usawoti we-organoammonium owumphumela wenhlanganisela yamanani alinganayo e-ketorolac ne-tromethamine (tris).Inemiphumela enamandla ye-analgesic engalalisi kanye ne-anti-inflammatory emaphakathi.Isetshenziswa ekulawulweni kwesikhashana kwezinhlungu zangemva kokuhlinzwa, kanye nakumathonsi esweni ukuze kudambise ukulunywa kwe-ocular okuhambisana nenkathi yokungezwani komzimba ne-conjunctivitis.

74103-07-4 - Ubungozi Nokuphepha:

Izimpawu Eziyingozi T - ezinobuthi
Amakhodi Engozi
R25 - Kunobuthi uma ugwinywe
R36/37/38 - Ukucasula amehlo, uhlelo lokuphefumula kanye nesikhumba.
R23/24/25 - Ubuthi ngokuhogela, ukuthintana nesikhumba futhi uma ugwinyiwe.
Incazelo Yokuphepha
S26 - Uma uthintana namehlo, geza ngokushesha ngamanzi amaningi futhi ufune iseluleko sezokwelapha.
S45 - Uma kwenzeka ingozi noma uzizwa ungaphilile, funa iseluleko sezokwelapha ngokushesha (bonisa ilebula noma nini lapho kunokwenzeka.)
I-S36/37/39 - Gqoka izingubo zokuzivikela ezifanele, amagilavu ​​nokuvikela iso/ubuso.
Ama-ID e-UN UN 2811 6.1/PG 3
I-WGK Germany 3
I-RTECS UY7759900
I-HS Code 2933995500
I-Hazard Class 6.1(a)
Ukupakisha Iqembu II

74103-07-4 - USP 35 Indlela Yokuhlaziya:

I-Ketorolac Tromethamine iqukethe okungengaphansi kwamaphesenti angama-98.5 futhi hhayi ngaphezu kwamaphesenti angu-101.5 we-C15H13NO3·C4H11NO3, abalwe ngokomisiwe.
Ukupakisha nokugcina-Londoloza ezitsheni eziqinile, ezimelana nokukhanya.Gcina ku-25°, uhambo oluvunyelwe phakathi kuka-15° no-30°
Amazinga ereferensi we-USP <11>-
USP Ketorolac Tromethamine RS
Ukuhlonza-
A: I-Infrared Absorption <197K>.
B: Ukumuncwa kwe-Ultraviolet <197U>-
Isixazululo: 10 µg ngemL
Okuphakathi: i-methanol.
C: Ukuhlolwa kwe-Tromethamine-Lungiselela isixazululo Esijwayelekile se-USP Ketorolac Tromethamine RS kwingxube ye-dichloromethane ne-methanol (2:1) equkethe u-5 mg ngemL ngayinye.Ngokufanayo lungiselela isisombululo sokuhlola se-Ketorolac Tromethamine esiqukethe u-5 mg nge-mL ngayinye.Sebenzisa amavolumu angu-40-µL esixazululo Esijwayelekile kanye nesixazululo sokuhlola kupuleti le-chromatographic lisendlalelo oluncane (bona i-Chromatography <621>) embozwe ngelendlalelo engu-0.25-mm yengxube yejeli ye-chromatographic silica.Beka ipuleti egunjini le-chromatographic ngaphambilini elihlanganiswe nengxube ye-dichloromethane, i-acetone, ne-glacial acetic acid (95:5:2).Vala igumbi, futhi uthuthukise i-chromatogram kuze kube yilapho ingaphambili le-solvent selinyakaze cishe izingxenye ezintathu kwezine zobude bepuleti.Susa ipuleti ekamelweni, futhi uvumele i-solvent ihwamuke.Fafaza ipuleti ngesisombululo sotshwala esisanda kulungiswa esiqukethe u-30 mg we-ninhydrin ngemL, bese ushisisa ipuleti cishe ku-150 ° imizuzu emi-2 kuya kwemi-5.Amachashaza aphuzi anomngcele opinki kuya kokunsomi akhula epuletini ezindaweni lapho isixazululo Esijwayelekile nesixazululo sokuhlola sisetshenziswe khona.
i-pH <791>: phakathi kuka-5.7 no-6.7, kusixazululo (1 ku-100).
Ukulahlekelwa ekumisweni <731>-Yomise ku-vacuum ku-60° amahora angu-3: ilahlekelwa ngaphezu kuka-0.5% wesisindo sayo.
Izinsalela ekushiseni <281>: hhayi ngaphezu kuka-0.1%.
Izinsimbi ezinzima, Indlela II <231>: 0.002%.
Ubumsulwa beChromatographic-
Isigaba seselula, ingxube ye-Solvent, ukulungiswa okujwayelekile, isixazululo sokuxazulula, kanye nesistimu ye-Chromatographic-Qhubeka njengoba kuqondiswe ku-Assay.
Isixazululo sokuhlola-Sebenzisa ukulungiswa kwe-Assay.
Inqubo-Chromatograph ikhambi Lokuhlola njengoba kuqondiswe Inqubo ku-Assay, okuvumela i-chromatography ukuthi inwebe izikhathi eziphindwe kathathu kunesikhathi sokugcinwa kwe-ketorolac.Linganisa izimpendulo zazo zonke iziqongo.Bala iphesenti lokungcola komuntu ngamunye engxenyeni ye-Ketorolac Tromethamine ethathwe ifomula:
I-100rfi (ri / rs)
lapho i-rfi iyisici sokuphendula sesiqongo sokungcola komuntu ngamunye esihlobene ne-ketorolac;I-ri iyimpendulo ephakeme kakhulu yokungcola ngakunye;futhi rs iyisamba sazo zonke izimpendulo eziphakeme zeziqongo zokungcola kanye nenani elikhulu le-ketorolac.Amanani e-rfi angu-0.52 ku-analog ye-ketorolac 1-keto, 0.67 ye-ketorolac 1-hydroxy analog, 2.2 ephakemeyo yokungcola enesikhathi sokugcina esingu-0.54 uma kuqhathaniswa nese-ketorolac, kanye no-0.91 ngenani eliphakeme lokungcola ngesikhathi sokugcinwa okuhlobene. ngo 0.66.Akukho ngaphezu kwe-0.1% ye-analog ye-ketorolac 1-keto noma i-analogue ye-ketorolac 1-hydroxy;hhayi ngaphezu kuka-0.5% wanoma yikuphi okunye ukungcola okutholakalayo;futhi isamba sakho konke ukungcola asikho ngaphezu kuka-1.0%.
Isivivinyo-
Isigaba seselula-Diza i-5.75 g ye-monobasic ammonium phosphate ku-1000 mL wamanzi, futhi ulungise ne-phosphoric acid ibe i-pH engu-3.0.Lungiselela ingxube ehlungiwe negayisiwe yalesi sixazululo sebhafa kanye ne-tetrahydrofuran (70:30).Yenza izinguquko uma kudingeka (bona Ukufaneleka Kwesistimu ngaphansi kwe-Chromatography <621>) ukuze uthole isikhathi sokugcinwa kwe-ketorolac cishe imizuzu eyi-8 ukuya kweyi-12.
Ingxube ye-solvent-Lungisa ingxube yamanzi ne-tetrahydrofuran (70:30).
Ukulungiselela okujwayelekile-Ncibilikisa ngokwesilinganiso inani elinembile le-USP Ketorolac Tromethamine RS kungxube ye-Solvent ukuze uthole isixazululo esinokugxila okwaziwayo okungaba ngu-0.4 mg nge-mL ngayinye.[QAPHELA-Vikela lesi sixazululo ekukhanyeni.]
Ukulungiselela i-Assay-Dlulisa cishe u-20 mg we-Ketorolac Tromethamine, ukalwe ngokunembile, uye ku-50-mL ye-volumetric flask, hlambulula ngengxube ye-Solvent ibe ivolumu, bese uxuba.[QAPHELA-Vikela lesi sixazululo ekukhanyeni.]
Isixazululo sokulungiswa-Enhlanganisela yesihlukanisi engu-250-mL 100 mL wamanzi, 100 mL we-dichloromethane, 30 mg we-USP Ketorolac Tromethamine RS, kanye no-1 mL we-1 N hydrochloric acid.Faka isivalo, unyakazise, ​​bese uvumela izendlalelo ukuthi zihlukane.Dlulisa ungqimba olungezansi lwe-dichloromethane kuflask yengilazi ye-borosilicate emisiwe, bese ulahla ungqimba olungaphezulu.Veza isisombululo se-dichloromethane ukuze uqondise ukukhanya kwelanga imizuzu eyi-10 kuya kweyi-15.Dlulisa u-1.0 mL wesixazululo ebhodleleni, uhwamuke emoyeni noma umfudlana we-nitrogen ukuze wome, engeza u-1.0 mL wengxube ye-Solvent, bese uzungeza ukuze uncibilike.[QAPHELA-Lesi sixazululo singagcinwa ngaphansi kwesiqandisi futhi sisetshenziswe inqobo nje uma ichromatogram etholwe njengoba iqondiswe kuNqubo ifaneleka ukuhlonza iziqongo ngenxa ye-ketorolac 1-keto analog ne-ketorolac 1-hydroxy analog, kanye nokukalwa kwesixazululo. phakathi kwe-ketorolac 1-keto analog ne-ketorolac.]
Isistimu ye-Chromatographic (bona i-Chromatography <621>)—I-chromatograph ewuketshezi ifakwe umtshina ongu-313-nm kanye nekholomu engu-4.6-mm × 25-cm equkethe okungu-5-µm okupakishwayo kwe-L7 futhi igcinwa kumazinga okushisa acishe abe ngu-40°.Izinga lokugeleza licishe libe ngu-1.5 mL ngomzuzu.I-Chromatograph isixazululo Sokulungiswa, futhi urekhode izimpendulo eziphezulu njengoba kuqondiswe kuNqubo: izikhathi zokugcinwa okuhlobene zicishe zibe ngu-0.63 ku-ketoroac 1-hydroxy analog, 0.89 ye-ketorolac 1-keto analog, kanye no-1.0 ye-ketorolac;futhi isixazululo, R, phakathi kwe-ketorolac 1-keto analog ne-ketorolac ayikho ngaphansi kuka-1.5.I-Chromatograph ukulungiselelwa Okujwayelekile, futhi urekhode izimpendulo eziphezulu njengoba kuqondiswe kuNqubo: ukusebenza kahle kwekholomu akukhona ngaphansi kwamapuleti etiyori angama-5500;futhi ukuchezuka okujwayelekile okuhlobene kwemijovo eyimpinda akukho ngaphezu kuka-1.5%.
Inqubo-Ngokuhlukile jova amavolumu alinganayo (cishe u-10 µL) wokulungiswa Okujwayelekile kanye nokulungiswa kwe-Assay ku-chromatograph, rekhoda ama-chromatogram, futhi ulinganise izimpendulo zeziqongo ezinkulu.Bala inani, ngo-mg, le-C15H13NO3·C4H11NO3 engxenyeni ye-Ketorolac Tromethamine ethathwe ifomula:
50C(rU / rS)
lapho u-C ewukugxila, ku-mg nge-mL ngayinye, ye-USP Ketorolac Tromethamine RS ekulungiseleleni Okujwayelekile;kanye ne-rU kanye ne-rS yizimpendulo eziphezulu ze-ketorolac ezitholwe ekulungiselelweni kwe-Assay nasekulungiseleleni Okujwayelekile, ngokulandelanayo.

Bhala umyalezo wakho lapha futhi usithumelele wona