I-L-Tryptophan CAS 73-22-3 (H-Trp-OH) Isivivinyo 98.5~101.5% Ikhwalithi Ephezulu Yefektri
I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi oholayo nomphakeli we-L-Tryptophan (H-Trp-OH; Trp noma W) (CAS: 73-22-3) enekhwalithi ephezulu.Njengomunye wabahlinzeki abakhulu bama-amino acid e-China, i-Ruifu Chemical ihlinzeka ngama-amino acid afika kumazinga omhlaba, njenge-AJI, USP, EP, JP kanye namazinga e-FCC.Singahlinzeka nge-COA, ukulethwa komhlaba wonke, amanani amancane kanye nenqwaba etholakalayo.Uma unentshisekelo ku-L-Tryptophan,Please contact: alvin@ruifuchem.com
| Igama Lekhemikhali | I-L-Tryptophan |
| Omqondofana | H-Trp-OH;L-(-)-Tryptophan;(-)-Tryptophan;I-Tryptophan;L-Trp;I-Trp efinyeziwe noma i-W;(S)-(-)-2-Amino-3-(3-Indolyl)propionic Acid;I-L-α-Amino-3-Indolepropionic Acid;2-Amino-3-(1H-Indol-3-yl)propanoic Acid |
| Isimo Sesitoko | Esitokweni, Amandla Okukhiqiza Amathani angama-3000 ngonyaka |
| Inombolo ye-CAS | 73-22-3 |
| I-Molecular Formula | I-C11H12N2O2 |
| Isisindo samangqamuzana | 204.23 |
| I-Melting Point | 282℃(dec.)(lit.) |
| Ukuminyana | 1.34 |
| Ukuncibilika kwamanzi | Incibilika Kancane Emanzini, 11.4 g/l 25℃ |
| Ukuncibilika | Incibilika Kancane ku-Ethanol.Incibilika Kancane Otshwaleni.Ayincibiliki ku-Ether, i-Chloroform |
| Ukuzinza | Izinzile.Akuhambisani nama-Acids Aqinile, Ama-ejenti Aqinile Oxidizing |
| Isikhathi Sokugcina. | Kuvalwe kokuthi Omile, Izinga lokushisa Legumbi |
| I-COA ne-MSDS | Iyatholakala |
| Ukwahlukanisa | Ama-Amino Acids kanye Neziqephu |
| Ibhrendi | I-Ruifu Chemical |
| Amakhodi Wengozi | Xi | I-RTECS | YN6130000 |
| Izitatimende Zobungozi | 33-40-62-41-37/38-36/37/38-22 | F | 8 |
| Izitatimende Zokuphepha | 24/25-36/37/39-36-26 | I-TSCA | Yebo |
| I-WGK Germany | 2 | Ikhodi ye-HS | 2922491990 |
| Izinto | Amazinga Wokuhlola | Imiphumela |
| Ukubukeka | Amakristalu Amhlophe noma I-Crystalline Powder | Kuyavumelana |
| Ukuhlonza | Ihlangabezana Nezimfuneko | Kuyavumelana |
| Ukuzungezisa Okuthile [α]20/D | -30.5° ukuya -32.5° (C=1,H2O) | -31.5° |
| Isimo Sesixazululo | ≥95.0% (I-Transmittance) | 96.7% |
| I-Chloride (Cl) | ≤0.020% | <0.020% |
| I-Sulfate (SO4) | ≤0.020% | <0.020% |
| I-Ammonium (NH4) | ≤0.020% | <0.020% |
| Insimbi (Fe) | ≤20ppm | Kuyavumelana |
| Izinsimbi Ezisindayo (Pb) | ≤10ppm | Kuyavumelana |
| I-Arsenic (As2O3) | ≤1.0ppm | Kuyavumelana |
| Amanye ama-Amino Acids | Ihlangabezana Nemfuneko | Kuyavumelana |
| Ukulahlekelwa Ekumisweni | ≤0.20% (ku-105℃ amahora angu-3) | 0.16% |
| Izinsalela ekushiseni (Sulfated) | ≤0.10% | 0.04% |
| Isivivinyo | 98.5~101.0% | 99.7% |
| pH | 5.4~6.4 (1.0g ku-100ml we-H2O ) | 5.8 |
| Ukungcola Okuguquguqukayo Kwezinto Eziphilayo | Ihlangabezana Nemfuneko | Kuyavumelana |
| I-Pyrogen | I-Nonpyrogenic | Kuyavumelana |
| Isiphetho:Lo Mkhiqizo Ngokuhlola Izivumelwano Nezinga le-EP5, AJI97, USP35 | ||
I-L-Tryptophan (H-Trp-OH) (CAS: 73-22-3) Indlela Yokuhlola ye-AJI 97
Ukuhlonza: Qhathanisa i-spectrum yokumuncwa kwe-infrared yesampula naleyo yezinga lendlela ye-potassium bromide disc.
Ukuzungezisa Okuthile [α]20/D: Isampula Eyomisiwe, C=1, H2O disolve ngokufudumeza
Isimo Sesixazululo (Ukudluliswa): 0.5g ku-20ml we-2 mol/L HCl, i-spectrophotometer, 430nm, 10mm ubukhulu beseli.
I-Chloride (Cl): 0.7g, A-1, ref: 0.40ml ka-0.01mol/L HCl
I-Ammonium (NH4): B-2
I-Sulfate (SO4): 1.2g, (1), ref: 0.50ml ka-0.005mol/L H2SO4
Insimbi (Fe): 0.75g, (2), ref: 1.5ml ye-Iron Std.(0.01mg/ml)
Izinsimbi Ezisindayo (Pb): 2.0g, (4), ref: 2.0ml ye-Pb Std.(0.01mg/ml)
I-Arsenic (As2O3): 2.0g, (1), ref: 2.0ml ye-As2O3 Std.
Amanye ama-Amino Acid: H2O, Dilisha ngokufudumeza (40℃) Isampula Lokuhlola: 50μg, A-6-a, control: L-Trp 0.25μg
Ukulahlekelwa Ekumisweni: ku-105 ℃ amahora angu-3.
Izinsalela Ekushiseni (I-Sulfated): Ukuhlolwa kwe-AJI 13
I-Assay: Isampula eyomisiwe, 200mg, (1), 3ml ye-formic acid, 50ml ye-glacial acetic acid, 0.1mol/L HCLO4 1ml=20.423mg C11H12N2O2
Ukuhlolwa kwe-pH: 1.0g ku-100ml we-H2O
I-L-Tryptophan (H-Trp-OH) (CAS: 73-22-3) Indlela Yokuhlola ye-USP35
INCAZELO
I-Tryptophan iqukethe i-NLT 98.5% kanye ne-NMT 101.5% ye-C11H12N2O2, njenge-L-Tryptophan, ibalwe ngokomisiwe.
UKUKHOMBA
A. UKUMUMVA OKUTHI INFRARED <197K>
ISIVIVINYO
INQUBO
Isixazululo sesampula: Beka u-200 mg we-Tryptophan kuflask engu-125-mL.Chaza kwinhlanganisela engu-3 mL we-formic acid kanye no-50 mL we-glacial acetic acid.
Ukuhlaziywa: Titrate ngo-0.1 N perchloric acid VS, ithola indawo yokugcina nge-potentiometrically.Yenza isinqumo esingenalutho, futhi wenze noma yikuphi ukulungisa okudingekayo (bona i-Titrimetry <541>).I-mL ngayinye ka-0.1 N perchloric acid ilingana no-20.42 mg we-C11H12N2O2.
Indlela yokwamukela: 98.5%~101.5% ngokomisiwe
UKUNGCOLA
Ukungcola Okungaphili
UKUSHISA OKUSELELE <281>: NMT 0.1%
I-CHLORIDE NE-SULFATE, I-Chloride <221>: Ingxenye engu-0.73-g ibonisa ukuthi ayisekho i-chloride ehambisana no-0.50 mL ka-0.020 N hydrochloric acid (0.05%).[QAPHELA-Shisisa kahle isampula yokulungiselela ukuze incibilike, uma kudingeka.]
I-CHLORIDE NE-SULFATE, I-Sulfate <221>: Ingxenye engu-0.33-g ayibonisi i-sulfate engaphezulu kokuhambisana no-0.10 mL ka-0.020 N sulfuric acid (0.03%).[QAPHELA-Shisisa kahle isampula yokulungiselela ukuze incibilike, uma kudingeka.
I-IRON <241>: NMT 30ppm
IZINSIMBI EZISINDAYO, Indlela II <231>: NMT 15ppm
Ukungcola Okuphilayo
INQUBO 1
Isixazululo A: I-Trifluoroacetic acid emanzini (1 mL/L)
Isixazululo B: I-Trifluoroacetic acid ku-acetonitrile nesisombululo samanzi (80:20) (1 mL/L isixazululo se-trifluoroacetic acid)
Isixazululo esijwayelekile: 1.0 mg/L ngayinye ye-USP Tryptophan Related Compound A RS kanye ne-USP Tryptophan Related Compound B RS emanzini
Isixazululo sesampula: 10.0 mg/mL ye-tryptophan emanzini
Isixazululo sokufaneleka kwesistimu: 1.0 mg/L ye-USP Tryptophan Related Compound B RS emanzini
Isigaba seselula: Bona ithebula legradient ngezansi.
| Isikhathi (imizuzu) | Isixazululo A (%) | Isixazululo B (%) |
| 0 | 95 | 5 |
| 2 | 95 | 5 |
| 37 | 35 | 65 |
| 42 | 0 | 100 |
| 47 | 0 | 100 |
| 50 | 95 | 5 |
| 60 | 95 | 5 |
Isistimu ye-Chromatographic (Bona i-Chromatography <621>, Ukufaneleka Kwesistimu.)
Imodi: LC
Umtshina: UV 220 nm
Ikholomu: 4.6-mm × 25-cm;5-µm ukupakisha i-L1
Izinga lokushisa lekholomu: 30°
Izinga lokugeleza: 1 mL/min
Usayizi womjovo: 20 µL
Ukufaneleka kwesistimu
Isampula: Isixazululo sokufaneleka kwesistimu
Imfuneko yokufaneleka
Ukuchezuka okujwayelekile okuhlobene: NMT 5.0%
Ukuhlaziya
Amasampula: Isixazululo esijwayelekile kanye nesixazululo esiyisampula
Bala iphesenti lokungcola ngakunye okungashiwongo engxenyeni ye-Tryptophan ethathiwe:
Umphumela = (rU/rS) × (CS/CU) × 100
rU = indawo ephakeme kakhulu yokungcola ngakunye okungashiwongo kusixazululo Sesampuli
rS = indawo ephakeme kakhulu ye-tryptophan ehlobene nenhlanganisela B kusixazululo Esijwayelekile
CS = ukugxila kwe-USP Tryptophan Related Compound B RS kusixazululo Esijwayelekile (µg/mL)
CU = ukugcwala kwe-Tryptophan kusixazululo Sesampula (µg/mL)
Imibandela yokwamukela
Ukungcola okuphelele 1: I-NMT 0.01% yakho konke ukungcola okudlulayo ngaphambi kwenani eliphakeme le-tryptophan
Ukungcola okuphelele 2: I-NMT 0.03% yakho konke ukungcola okuphuma ngemva kwenani eliphakeme le-tryptophan.[QAPHELA-Ungafaki inani eliphakeme lenhlanganisela ehlobene ne-tryptophan B.]
Inhlanganisela ehlobene ne-Tryptophan A: Uma inani eliphakeme lenhlanganisela ehlobene ne-tryptophan A libonwa kusixazululo Sesampula, bese wenza ukuhlolwa kweNqubo 2: Umkhawulo we-Tryptophan Related Compound A, ngezansi.
INKQUBO 2: UMKHAWULO WECOMPOUND Ehlobene ne-TRYPTOPHAN A
Isixazululo A: 18 mM monobasic sodium phosphate, ehlungiwe futhi ekhishwe umoya (pH 2.5), ne-acetonitrile (9:1)
Isixazululo B: 10 mM monobasic sodium phosphate, ehlungiwe futhi ekhishwe umoya (pH 2.5), ne-acetonitrile (1:1)
Isixazululo C: I-acetonitrile emanzini (7:3)
Isixazululo esijwayelekile: 0.1 mg/L ye-USP Tryptophan Related Compound A RS emanzini
Isixazululo sesampula: 10.0 mg/mL ye-Tryptophan emanzini
Isigaba seselula: Bona ithebula legradient ngezansi
| Isikhathi (imizuzu) | Isixazululo A (%) | Isixazululo B (%) | Isixazululo C (%) |
| 0 | 100 | 0 | 0 |
| 30 | 44 | 56 | 0 |
| 30.1 | 0 | 0 | 100 |
| 45 | 0 | 0 | 100 |
| 45.1 | 100 | 0 | 0 |
| 60 | 100 | 0 | 0 |
Isistimu yeChromatographic
(Bona i-Chromatography <621>, Ukufaneleka Kwesistimu.)
Imodi: LC
Umtshina: UV 216 nm
Ikholomu: 3.9-mm × 15-cm;5-µm ukupakisha i-L1
Izinga lokushisa lekholomu: 30°
Izinga lokugeleza: 1 mL/min
Usayizi womjovo: 20 µL
Ukufaneleka kwesistimu
Isampula: Isixazululo esijwayelekile
Imfuneko yokufaneleka
Ukuchezuka okujwayelekile okuhlobene: NMT 5.0%
Ukuhlaziya
Amasampula: Isixazululo esijwayelekile kanye nesixazululo esiyisampula
Bala iphesenti lenhlanganisela ehlobene ne-tryptophan
A engxenyeni ye-Tryptophan ethathiwe:
Umphumela = (rU/rS) × (CS/CU) × 100
rU = indawo ephakeme kakhulu yenhlanganisela ye-tryptophan ehlobene ne-A kusixazululo Sesampula
rS = indawo ephakeme kakhulu yenhlanganisela ehlobene ne-tryptophan A kusixazululo Esijwayelekile
CS = ukugxila kwe-USP Tryptophan Related Compound A RS kusixazululo Esijwayelekile (µg/mL)
CU = ukugcwala kwe-Tryptophan kusixazululo Sesampula (µg/mL)
Indlela yokwamukela: NMT 10 ppm
IZIVIVINYO EZITHILE
UKUZUNGUZA KWE-OPTICAL, Ukuzungezisa Okuqondile <781S>: -29.4° kuya -32.8°
Isixazululo sesampula: 10 mg/mL, emanzini.[QAPHELA-Shisisa kancane ukuze uncibilike, uma kudingeka.]
PH <791>: 5.5~7.0, kusixazululo (1 ku-100)
UKULAHLEKELWA EKOMISENI <731>: Yomisa isampula ku-105° amahora angu-3: ilahlekelwa yi-NMT ngo-0.3% wesisindo sayo.
IZIDINGO EZENGEZIWE
UKUPAKASHA KANYE NESIGCINI: Londoloza ezitsheni ezivalwe kahle
I-USP REFERENCE AMAZINGA <11>
I-USP L-Tryptophan RS
I-USP Tryptophan Related Compound A RS
3,3′-[Ethylidenebis(1H-indole-1,3-diyl)]bis[2S)-2-aminopropanoic]asidi.I-C24H26N4O4 432.49
I-USP Tryptophan Related Compound B RS
2-Acetamido-3-(1H-indol-3-yl) propanoic acid.I-C13H14N2O3 246.3
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Amakhodi Engozi R33 - Ingozi yemiphumela eqoqwayo
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I-R62 - Ingozi engaba khona yokukhubazeka kokuzala
R41 - Ingozi yokulimala okubi emehlweni
R37/38 - Ukucasula uhlelo lokuphefumula kanye nesikhumba.
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R22 - Iyingozi uma igwinywe
Incazelo Yezokuphepha S24/25 - Gwema ukuthintana nesikhumba namehlo.
I-S36/37/39 - Gqoka izingubo zokuzivikela ezifanele, amagilavu nokuvikela iso/ubuso.
I-S36 - Gqoka izingubo ezifanele zokuzivikela.
S26 - Uma uthintana namehlo, geza ngokushesha ngamanzi amaningi futhi ufune iseluleko sezokwelapha.
I-L-Tryptophan (H-Trp-OH) (i-CAS: 73-22-3) iyi-amino acid edingekayo ukuze kukhule izilwane ezisencane futhi iyinhloko yama-amino acid asetshenziswa ekudleni ngemva kwe-lysine, i-methionine ne-threonine.Ukwengeza i-tryptophan kungathuthukisa ukusebenza kahle kokusetshenziswa kwama-amino acid, kwandise ukudla okudliwayo, kukhuthaze ukukhula futhi kuthuthukise amasosha omzimba.Ukusabela kokucindezeleka kwamazingulube ngemva kokulunyulwa kungakhululeka futhi ukusebenza kahle kokuzalanisa kungathuthukiswa nge-tryptophan, esetshenziswe kakhulu ekudleni.Izithako zokudla okunomsoco.Ingxenye ebalulekile yokufakwa kwe-amino acid kanye namalungiselelo aphelele e-amino acid.Ingalapha ukushoda kwe-niacin.Isetshenziswa ocwaningweni lwe-biochemical, njenge-sedative kwezokwelapha.Umuntu: i-nutrition supplement.i-antioxidant.I-Tryptophan iyisandulela se-5-hydroxytryptamine, i-neurotransmitter ebalulekile emzimbeni womuntu.Ingenye yama-amino acid abalulekile emzimbeni womuntu;Izithako zokudla okunomsoco kwabesifazane abakhulelwe kanye nempushana yobisi ekhethekile yezingane ezincane;Izidakamizwa zokwelashwa kokuntuleka kwe-niacin (pellagra);Njenge-tranquilizer, ingalawula isigqi somqondo futhi ithuthukise ukulala.Izilwane: khuthaza ukudla kwezilwane, nciphisa ukuphendula kwengcindezi, thuthukisa ukulala kwezilwane, khulisa amasosha omzimba engane kanye nezinsana futhi athuthukise ukumunyisa kwezilwane zobisi.Yehlisa inani leprotein yokudla yekhwalithi ephezulu, yonga izindleko zokudla, yehlisa inani lokudla kwamaprotheni, futhi wonge isikhala sefomula.Isicelo mayelana ne-L-Tryptophan: L-Tryptophan uhlobo lwesithasiselo sokudla okunempilo.I-L-Tryptophan ingathuthukisa i-aerobic metabolism ye-muscle futhi ithuthukise kakhulu amandla emisipha nokukhuthazela okuvela ekudleni kuphela.I-L-Tryptophan ingasetshenziswa njengesithuthukisi somsoco.I-L-Tryptophan ingesinye sezithako zokudla okunomsoco ezithandwa kakhulu futhi ezisebenzayo kanye nomkhiqizo obalulekile wabakhi bomzimba.
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