I-LCZ696 I-CAS 1426129-50-1 Ubumsulwa ≥98.0% (HPLC) ee ≥99.0% Factory High Purity
I-Commercial Supply LCZ696 (CAS: 936623-90-4) Izikhulumi Ezihlobene:
(R)-tert-Butyl (1-([1,1-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate CAS: 1426129-50-1
(R,E)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid CAS: 1012341-48-8
(2R,4S)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid CAS: 1012341-50-2
(2R,4S)-ethyl 5-(1,1'-biphenyl-4-yl)-4-amino-2-methylpentanoate HCl CAS: 149690-12-0
I-AHU-377 (usawoti we-hemicalcium) I-CAS: 1369773-39-6
I-AHU-377;I-Sacubitril CAS: 149709-62-6
I-LCZ696;I-Entresto;Ingxube ye-Sacubitril ne-Valsartan CAS: 936623-90-4
| Igama Lekhemikhali | (R)-tert-Butyl (1-([1,1-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate |
| Omqondofana | Idatha ye-LCZ696 |
| Inombolo ye-CAS | 1426129-50-1 |
| Inombolo yeCAT | I-RF-PI169 |
| Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifinyelela Emakhulwini Amakhilogremu |
| I-Molecular Formula | I-C20H25NO3 |
| Isisindo samangqamuzana | 327.42 |
| Ibhrendi | I-Ruifu Chemical |
| Into | Imininingwane |
| Ukubukeka | Impushana Emhlophe Kuya Kumhlophe |
| Ukuhlanzeka / Indlela Yokuhlaziya | ≥98.0% (HPLC) |
| I-Enantiomeric Excess | ee: ≥99.0% |
| Umswakama (KF) | ≤1.0% |
| Izinto Ezihlobene A | ≤1.0% (RRT=0.5) A=(R)-3-([1,1'-biphenyl]-4-yl)-2-aminopropan-1-ol |
| Izinto Ezihlobene B | ≤1.0% (RRT=0.85) B=Triphenylphosphine oxide |
| Ezinye Izinto | ≤1.0% |
| Ukungcola Okuphelele | ≤2.0% |
| Izinga Lokuhlola | I-Enterprise Standard |
| Ukusetshenziswa | Okuphakathi kwe-LCZ696 (CAS: 936623-90-4) ekwelapheni i-HFrEF |
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, isigubhu seCardboard, 25kg/Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni, umswakama kanye nezinambuzane.
Umkhiqizi onokuhlanzeka Okuphezulu kanye Nekhwalithi Ezinzile
I-Commercial Supply LCZ696 (CAS: 936623-90-4) Izikhulumi Ezihlobene:
(R)-tert-Butyl (1-([1,1-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate CAS: 1426129-50-1
(R,E)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid CAS: 1012341-48-8
(2R,4S)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid CAS: 1012341-50-2
(2R,4S)-ethyl 5-(1,1'-biphenyl-4-yl)-4-amino-2-methylpentanoate HCl CAS: 149690-12-0
I-AHU-377 (usawoti we-hemicalcium) I-CAS: 1369773-39-6
I-AHU-377;I-Sacubitril CAS: 149709-62-6
I-LCZ696;I-Entresto;Ingxube ye-Sacubitril ne-Valsartan CAS: 936623-90-4
I-LCZ696 iwumuthi ohlolwayo owakhiwe i-Novartis Pharmaceutical yase-United States ukuze ulaphe iziguli ezine-Heart Failure ene-Ejection Fraction (HFrEF) encishisiwe.Ukuhluleka kwenhliziyo kuyisifo esisongela ukuphila.Inhliziyo yesiguli ayikwazi ukupompa igazi elanele ukunikeza umzimba, futhi avele izimpawu dyspnea, ukukhathala nokugcinwa uketshezi kancane, bese kancane kancane anda, kakhulu kuthinta izinga lokuphila.I-LCZ696 ingathuthukisa ukuzivikela kwemvelo komzimba ngokumelene nokuhluleka kwenhliziyo, kanye nokwandisa izinga lama-peptide e-natriuretic namanye ama-peptide e-endogenous vasoactive, futhi ivimbele uhlelo lwe-renin-angiotensin-aldosterone (RAAS).I-LCZ696 ihlanganiswe ne-Novartis's Hypertension Medication (i-Diovan, igama elijwayelekile: valsartan) kanye nomuthi wokuhlola i-AHU-377.I-AHU377 ivimba indlela yama-peptide amabili anesibopho sokwehlisa umfutho wegazi.I-Diovan ithuthukisa i-vasodilatation futhi ikhuthaze umzimba ukuthi ukhiphe i-sodium namanzi.
