I-Lenvatinib Mesylate CAS 857890-39-2 Assay 98.0~102.0% Isithombe Esifakiwe Sefekthri

I-Lenvatinib Mesylate CAS 857890-39-2 Assay 98.0~102.0% Factory

Incazelo emfushane:

Igama Lekhemikhali: Lenvatinib Mesylate

I-CAS: 857890-39-2

Isilinganiso: 98.0 ~ 102.0%

Ukubukeka: Impushana emhlophe iye kokumhlophe noma amakristalu

Thintana: UDkt. Alvin Huang

Iselula/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Imikhiqizo Ehlobene

Omaka bomkhiqizo

Incazelo:

I-Ruifu Chemical Supply Lenvatinib Mesylate Intermediates With High Purity
I-Lenvatinib Mesylate CAS 857890-39-2
4-Chloro-7-Methoxyquinoline-6-Carboxamide CAS 417721-36-9
I-Desquinolinyl Lenvatinib;1-(2-Chloro-4-Hydroxyphenyl)-3-Cyclopropylurea CAS 796848-79-8
I-Methyl 7-Methoxy-4-Oxo-1,4-Dihydroquinoline-6-Carboxylate CAS 205448-65-3
I-Methyl 4-Amino-2-Methoxybenzoate CAS 27492-84-8
5-(Methoxymethylene)-2,2-Dimethyl-1,3-Dioxane-4,6-Dione CAS 15568-85-1
I-4-Amino-3-Chlorophenol CAS 17609-80-2
I-4-Amino-3-Chlorophenol Hydrochloride CAS 52671-64-4
I-Methyl 4-Chloro-7-Methoxyquinoline-6-Carboxylate CAS 205448-66-4

Chemical Properties:

Igama Lekhemikhali	Lenvatinib Mesylate
Omqondofana	4- [3-Chloro-4-[(cyclopropylaminocarbonyl)amino]phenoxy]-7-Methoxy-6-Quinolinecarboxamide Mesylate;E 7080 Mesylate;Lenvima
Inombolo ye-CAS	857890-39-2
Inombolo yeCAT	I-RF-PI1975
Isimo Sesitoko	Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani
I-Molecular Formula	I-C21H19N4O4Cl.CH4O3S
Isisindo samangqamuzana	522.96
Ibhrendi	I-Ruifu Chemical

Imininingwane:

Into	Imininingwane
Ukubukeka	Impushana emhlophe ukuya kokumhlophe noma amakristalu
Ukuhlonza	Nge-IR;Nge-UV;Nge-HPLC
Ukuncibilika	Incibilika Kancane Emanzini, Ayincibiliki ku-Ethanol
I-Melting Point	228.0~230.0℃
Okuqukethwe kwamanzi (KF)	<1.00%
Izinsalela ekushiseni	<0.10%
Izinsimbi Ezisindayo	<20ppm
Izinto Ezihlobene
Noma Ikuphi Ukungcola Okukodwa	<0.50%
Ukungcola Okuphelele	<1.00%
Indlela Yokuhlola / Yokuhlaziya	98.0~102.0% (HPLC Isisekelo Sokomisa)
Ukuminyana kwenqwaba	0.40gm/ml~0.60gm/ml
Izinga Lokuhlola	I-Enterprise Standard
Ukusetshenziswa	I-API

Iphakheji nesitoreji:

Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwemfuneko yekhasimende

Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni nakumswakama

Izinzuzo:

I-FAQ:

Isicelo:

I-Lenvatinib Mesylate (CAS: 857890-39-2) iyi-inhibitor yomlomo futhi ehlosiwe kaningi ye-VEGFR1-3, FGFR1-4, PDGFR, KIT, ne-RET, enemisebenzi enamandla ye-antitumor.I-Lenvatinib Mesylate iyi-inhibitor ye-receptor tyrosine kinase (RTK) enokukhethwa kwe-VEGFR2.Ibonisa umsebenzi we-antineoplastic, futhi iboniswe ekwelapheni iziguli ezinomdlavuza we-thyroid ophindaphindiwe noma we-metastatic, oqhubekayo, we-radioactive (RAI) -refractory.I-Lenvatinib Mesylate yagunyazwa okokuqala yi-US Food and Drug Administration (FDA) ngo-Feb 13, 2015, yabe isigunyazwa i-Pharmaceuticals and Medical Devices Agency of Japan (PMDA) ngo-Mar 26, 2015, futhi yavunyelwa yi-European Medicine Agency (EMA) ngo- May 28, 2015. Yasungulwa futhi yakhangiswa njenge-Lenvima® ngabakwa-Eisai.I-Lenvatinib Mesylate iyi-oral multiple receptor tyrosine kinase inhibitor enemodi yokubopha eyingqayizivele evimbela ngokukhetha imisebenzi ye-kinase ye-vascular endothelial growth factor (VEGF) receptors, ngaphezu kwamanye ama-proangiogenic kanye ne-oncogenic pathway ehlobene ne-tyrosine kinases okucatshangwa ukuthi ihileleke ekwandeni kwesimila. .Ikhonjiswe ekwelapheni umdlavuza wegilo oqhubekayo we-radioiodine-refractory.Lenvimaisetshenziswa yona ngokwayo ukwelapha umdlavuza wegilo (i-DTC), uhlobo lomdlavuza wegilo ongasakwazi ukwelashwa nge-iodine enemisebe futhi oluqhubekayo.I-LENVIMA isetshenziswa kanye nomunye umuthi obizwa ngokuthi i-everolimus ukwelapha abantu abadala abanohlobo lomdlavuza wezinso olubizwa ngokuthi i-Advanced renal cell carcinoma (RCC) ngemva kwenkambo yokwelashwa ngomunye umuthi wokulwa nomdlavuza.