Lesinurad (RDEA 594) CAS 878672-00-5 Purity >99.5% (HPLC) Assay 98.0~102.0%
I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi ohamba phambili weLesinurad (RDEA 594) (CAS: 878672-00-5) enekhwalithi ephezulu.I-Ruifu Chemical inganikeza ukulethwa komhlaba wonke, intengo encintisanayo, isevisi enhle kakhulu, amanani amancane kanye nenqwaba etholakalayo.Thenga i-Lesinurad kanye ne-Intermediates,Please contact: alvin@ruifuchem.com
| Igama Lekhemikhali | Lesinurad |
| Omqondofana | 2--[[5-Bromo-4-(4-Cyclopropylnaphthalen-1-yl)-4H-1,2,4-Triazol-3-yl]thio]acetic Acid;2-[[5-Bromo-4-(4-Cyclopropyl-1-Naphthalenyl)-4H-1,2,4-Triazol-3-yl]thio]-Acetic Acid;I-RDEA 594;I-RDEA-594;I-RDEA594;I-Zurampic |
| Isimo Sesitoko | Ku-Stock, Commercial Production |
| Inombolo ye-CAS | 878672-00-5 |
| I-Molecular Formula | I-C17H14BrN3O2S |
| Isisindo samangqamuzana | 404.28 g/mol |
| I-Melting Point | >171℃(dec.) |
| Ukuminyana | 1.72±0.10 g/cm3 |
| I-COA ne-MSDS | Iyatholakala |
| Umsuka | Shanghai, China |
| Ibhrendi | I-Ruifu Chemical |
| Izinto | Amazinga Wokuhlola | Imiphumela |
| Ukubukeka | Impushana Emhlophe Kuya Kumhlophe | I-Off-White Powder |
| Ukuhlonza | Isikhathi sokugcinwa kwesilinganiso esiphezulu sesixazululo sesampula sihambisana nezinga lereferensi | Iyahambisana |
| Amanzi nguKarl Fischer | <0.50% | 0.14% |
| Izinsalela ekushiseni | <0.10% | 0.03% |
| Izinsimbi Ezisindayo (Pb) | ≤10ppm | <10ppm |
| Izinto Ezihlobene (HPLC) | ||
| Ukungcola Okukodwa Okukhulu Kakhulu | <0.20% | 0.07% |
| Ukungcola Okuphelele | <1.00% | 0.24% |
| Ukuhlanzeka / Indlela Yokuhlaziya | >99.5% (Indawo ye-HPLC) | 99.76% |
| Isivivinyo | 98.0~102.0% | 99.6% |
| I-Infrared Spectrum | Ivumelana Nesakhiwo | Iyahambisana |
| I-NMR Spectrum | Ivumelana Nesakhiwo | Iyahambisana |
| Isiphetho | Umkhiqizo uhloliwe futhi uthobela imininingwane enikeziwe | |
Iphakheji:Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
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Ukuthumela:Zilethe emhlabeni wonke ngendiza, yi-FedEx/DHL Express.Nikeza ukulethwa okusheshayo nokuthembekile.
Indlela Yokuthenga?Sicela uxhumaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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Izimakethe Eziyinhloko?Thengisa emakethe yasekhaya, eNyakatho Melika, eYurophu, eNdiya, eKorea, eJapane, e-Australia, njll.
Izinzuzo?Ikhwalithi ephezulu, intengo ethengekayo, izinsizakalo ezichwepheshile nokusekelwa kobuchwepheshe, ukulethwa okusheshayo.
IkhwalithiIsiqiniseko?Isistimu yokulawula ikhwalithi eqinile.Imishini yobuchwepheshe yokuhlaziya ifaka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, NOMA, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njll.
Amasampula?Imikhiqizo eminingi inikeza amasampula wamahhala wokuhlolwa kwekhwalithi, izindleko zokuthumela kufanele zikhokhelwe amakhasimende.
Ukuhlolwa Kwemboni?Wamukelekile ekucwaningweni kwemboni.Sicela wenze i-aphoyintimenti kusengaphambili.
I-MOQ?Ayikho i-MOQ.I-oda elincane liyamukeleka.
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Ezokuthutha?By Express (FedEx, DHL), by Air, by Sea.
Amadokhumenti?Ngemuva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njll.
Custom Synthesis?Ingahlinzeka ngezinsizakalo zokwenziwa ngokwezifiso ukuze zilingane kangcono nezidingo zakho zocwaningo.
Imigomo Yokukhokha?I-invoyisi ye-Proforma izothunyelwa kuqala ngemva kokuqinisekiswa kwe-oda, kufakwe nemininingwane yethu yasebhange.Inkokhelo nge-T/T (Telex Transfer), PayPal, Western Union, njll.
I-Lesinurad (RDEA 594) (CAS: 878672-00-5) yagunyazwa yi-US Food and Drug Administration (FDA) ngo-December 22, 2015, yase yavunyelwa yi-European Medicines Agency (EMA) ngo-February 18, 2016. I-compound yasungulwa ngaphambili ngu-Ardea.I-AstraZeneca yathola inkampani ngo-2012, nayo yathola umkhiqizo.Igama lokuhweba lomuthi yi-Zurampic® e-United States nase-European Union.I-Lesinurad iyi-inhibitor yokuqala emhlabeni egunyazwe i-urate reuptake transporter (URAT1), ehlanganiswe ne-xanthine oxidase inhibitors ukwelapha i-gout ehlobene ne-hyperuricemia.
Lesinurad, igama lokuhweba Zurampic.I-Lesinurad ihlanganiswe ne-xanthine oxidase inhibitor (XOI) ye-hyperuricemic gout syndrome.Indlela yayo yokusebenza iwukusiza izinso ukuthi zikhiphe i-uric acid, futhi isebenza ngokuvimbela umsebenzi wabathuthi abahilelekile ekubuyiselweni kwe-uric acid ezinso.
I-Lesinurad ivimbela umsebenzi wokuthutha we-uric acid (IC50=3.36 μM) ye-hURAT1 (URAT1 yomuntu), okungaphezu kokuphindwe izikhathi ezingu-20 umphumela ovimbelayo ku-rURAT1 (i-rat URAT1) (IC50=74.84 μM).I-Lesinurad ivimbela i-hURAT1 ngokusebenzisana kwezinsalela ezibalulekile ze-amino acid Phe365.
