I-Letrozole CAS 112809-51-5 API Factory Aromatase Inhibitor II Ikhwalithi ephezulu
Nikeza Ngokuhlanzeka Okuphezulu kanye Nekhwalithi Ezinzile
Igama Lekhemikhali: I-Letrozole
I-CAS: 112809-51-5
I-Aromatase Inhibitor II
Ikhwalithi ephezulu ye-API, Ukukhiqiza Kwezentengiso
| Igama Lekhemikhali | I-Letrozole |
| Omqondofana | CGS-20267;Femara |
| Inombolo ye-CAS | 112809-51-5 |
| Inombolo yeCAT | I-RF-API86 |
| Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifika Emakhulwini Amakhilogremu |
| I-Molecular Formula | I-C17H11N5 |
| Isisindo samangqamuzana | 285.3 |
| I-Melting Point | 181.0 ukuze 183.0 ℃ |
| Ibhrendi | I-Ruifu Chemical |
| Into | Imininingwane |
| Ukubukeka | I-Crystalline Powder emhlophe ukuya kokumhlophe |
| Ukuncibilika | Incibilika Ngokukhululekile ku-Dichloromethane, Incibilika Kancane ku-Ethanol futhi Ayincibiliki Emanzini |
| Ukuhlonza IR | I-Spectrum yesampula ihambisana naleyo yezinga lereferensi |
| Ukuhlonza HPLC | Isikhathi sokugcinwa kwesampula yokuhlola sihambisana naleso sezinga lesithenjwa |
| Okuqukethwe kwamanzi (nge-KF) | ≤0.30% |
| Izinsalela ekushiseni | ≤0.10% |
| Izinto Ezihlobene | |
| Izinto Ezihlobene A | ≤0.30% |
| Izinto Ezihlobene B | ≤0.20% |
| Noma Ikuphi Ukungcola Okungashiwongo | ≤0.10% |
| Isamba Sokungcola Okungashiwongo | ≤0.30% |
| Ukungcola Okuphelele | ≤0.50% |
| Izincibilikisi Ezisele | |
| I-Ethyl Acetate | ≤0.50% |
| I-Methanol | ≤0.30% |
| I-Ethanol | ≤0.50% |
| I-DMF | ≤0.088% |
| Izinsimbi Ezisindayo | ≤10ppm |
| Isivivinyo | 98.0%~102.0% (kwisisekelo esingenamanzi) |
| I-Shelf Life | Izinyanga ezingama-24 |
| Izinga Lokuhlola | I-Enterprise Standard |
| Ukusetshenziswa | I-API, i-Aromatase Inhibitor II |
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, isigubhu seCardboard, 25kg/Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni, umswakama kanye nezinambuzane.
I-Letrozole (CAS 112809-51-5) iyingxenye yesizukulwane esisha se-aromatase inhibitors ekhethwa kakhulu futhi iwukuphuma kokwenziwa kwe-benzotriazole.I-Letrozole ivimbela i-aromatase ekunciphiseni amazinga e-estrogen, ngaleyo ndlela ivimbele i-estrogen ekukhuthazeni ukukhula kwesimila.Umsebenzi wayo we-vivo unamandla izikhathi ezingu-150-250 kunowesizukulwane sokuqala se-aromatase inhibitor i-Amarante.Njengoba ikhetha kakhulu, ngeke ithinte i-glucocorticoid, i-mineralocorticoid kanye nemisebenzi ye-thyroid;ngisho nangemithamo ephezulu, ngeke ibe nemiphumela evimbela ekukhiqizweni kwe-adrenal corticosteroid, inikeze inkomba ephezulu yokwelashwa.I-Letrozole ayinabo ubuthi obucashile maqondana nanoma yiziphi izinhlelo zomzimba nezitho eziqondiwe, ayinazo imiphumela ye-mutagenicity ne-carcinogenic, inemiphumela engemihle enobuthi obuncane, ibekezelelwa kahle, futhi inemiphumela eqinile yokulwa nomdlavuza kunezinye izidakamizwa ze-aromatase nezidakamizwa ze-antiestrogen.I-Letrozole ifaneleka ezigulini ezithuthukile zomdlavuza webele ngemuva kokuya esikhathini ezingakaphenduli ekwelashweni kokucindezela i-estrogen kanye nokwelashwa komdlavuza webele kusenesikhathi.Isetshenziselwa ukwelapha iziguli zangemuva kokuya esikhathini ezinomdlavuza webele othuthukile futhi isebenza njengokwelashwa komugqa wesibili ukulandela ukwelashwa okungaphumelelanga kwe-antiestrogen.
