I-Lopinavir CAS 192725-17-0 API Anti-HIV HIV Protease Inhibitor COVID-19 High Purity
Ukunikezela Komkhiqizi Ngokuhlanzeka Okuphezulu kanye Nekhwalithi Ezinzile
Igama Lekhemikhali: Lopinavir
CAS: 192725-17-0
I-Peptidomimetic HIV-1 Protease Inhibitor Enamandla Kakhulu, Ekhethiwe
Umkhiqizo Wocwaningo Oluhlobene ne-COVID-19
Ikhwalithi ephezulu ye-API, Ukukhiqiza Kwezentengiso
Igama Lekhemikhali | I-Lopinavir |
Omqondofana | I-LPV;I-ABT-378;Kaletra |
Inombolo ye-CAS | 192725-17-0 |
Inombolo yeCAT | I-RF-API73 |
Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifika Emakhulwini Amakhilogremu |
I-Molecular Formula | I-C37H48N4O5 |
Isisindo samangqamuzana | 628.81 |
Isitoreji Sesikhathi Eside | Gcina Isikhathi Eside ku-2-8℃ |
Ibhrendi | I-Ruifu Chemical |
Into | Imininingwane |
Ukubukeka | Impushana Emhlophe Kuya Kumhlophe |
Ukuncibilika | I-Soluble Ngokukhululekile ku-Methanol naku-Ethanol, I-Soluble ku-2-Propanol |
Ukuhlonza IR | I-spectrum yokumuncwa kwe-infrared yesampula yokuhlola ihambisana ne-spectrum yezinga lereferensi |
Ukuhlonza HPLC | Isikhathi sokugcinwa kwesampula yokuhlola sihambisana naleso sezinga lesithenjwa |
Okuqukethwe kwamanzi (nge-KF) | ≤4.0% |
I-Specific Optical Rotation | -22.0° ukuze -26.0° |
Izinsalela ekushiseni | ≤0.20% |
Izinsimbi Ezisindayo | ≤20ppm |
I-Melting Point | 124.0 ukuze 127.0 ℃ |
Umlotha one-sulphate | ≤0.20% |
I-Residual Solvent (Ethanol) | ≤0.50% |
Izinto Ezihlobene | (HPLC, Area%) |
Ukungcola 1 | |
Ukungcola B (RRT=0.07) | ≤0.20% |
Ukungcola I (RRT=1.10) | ≤0.20% |
Noma Ikuphi Okunye Ukungcola | ≤0.10% |
Ukungcola 2 | Noma Ikuphi Okunye Ukungcola Komuntu Ngamunye ≤0.10% |
Ukungcola Okuphelele Kwenqubo 1 kanye No-2 | ≤0.70% |
Ukungcola Okuphelele | ≤1.0% |
I-Assay (nge-HPLC) | 98.0%~102.0% |
Izinga Lokuhlola | I-Enterprise Standard |
Ukusetshenziswa | I-Peptidomimetic HIV-1 Protease Inhibitor, Umkhiqizo Wocwaningo Oluhlobene ne-COVID-19 |
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, isigubhu seCardboard, 25kg/Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni, umswakama kanye nezinambuzane.
I-Lopinavir (ABT-378) iyi-peptidomimetic inhibitor enamandla kakhulu, ekhethayo ye-HIV-1 protease, ene-Kis engu-1.3 kuya ku-3.6 pM yohlobo lwasendle kanye ne-HIV protease eguquguqukayo.I-Lopinavir isebenza ngokunqanda ukuvuthwa kwe-HIV-1 ngaleyo ndlela ivimbe ukungatheleleki kwayo.I-Lopinavir iphinde ibe yi-SARS-CoV 3CLpro inhibitor ene-IC50 ye-14.2 μM.I-Lopinavir iyi-antiretroviral yesigaba se-protease inhibitor.Ukuvinjelwa kwe-HIV-1 protease kuvimbela ukuqhekeka kwe-viral polyprotein precursor futhi kuphumela ekukhululweni kwama-virion angavuthiwe, angatheleleki.Ingxenye yokwelapha okuyinhlanganisela yokwelapha i-HIV/AIDS.I-Lopinavir, inhibitor yesithupha ye-HIV protease inhibitor esigabeni “se-navir”, yethulwa ngokuhambisana ne-ritonavir, enye i-HIV protease inhibitor esivele imakethwa (Abbott, 1996);lokhu kwakhiwa kwasekuqaleni kwethulwa njenge-Kaletra ukuze kusetshenziswe ngokuhambisana ne-nucleoside noma i-non-nucleoside reverse transcriptase inhibitors yokwelapha ingculaza kubantu abadala nasezinganeni.I-Lopinavir iyinhlanganisela ye-peptidomimetic enomongo wesakhiwo ofana naleyo ye-ritonavir, lapho amaqembu abulalayo, ikakhulukazi i-valine eshintshiwe, yethulwa ngezinqubo zokuhlanganisa i-peptide.I-Lopinavir iyi-inhibitor enamandla yokuncintisana ye-HIV-I protease ebonisa amandla aphezulu ngokumelene nezinguquko ezimelana ne-ritonavir.Ezinhlotsheni zezilwane ezimbalwa, izifundo ze-pharmacokinetic nenhlangano ye-lopinavirlritonavir zibonise ukuthi izakhiwo ezinesizotha ze-lopinavir zathuthukiswa kakhulu lapho kukhona i-ritonavir, ngokuya nge-Cmax kanye nobude besikhathi sokusebenza.