I-Lopinavir CAS 192725-17-0 API Anti-HIV HIV Protease Inhibitor COVID-19 High Purity

Incazelo emfushane:

Igama Lekhemikhali: Lopinavir

CAS: 192725-17-0

Ukubukeka: Impushana Emhlophe Kuya Emhlophe

I-Assay (HPLC): 98.0%~102.0%

I-Peptidomimetic HIV-1 Protease Inhibitor ekhethiwe

Ikhwalithi ephezulu ye-API, Ukukhiqiza Kwezentengiso

Inquiry: alvin@ruifuchem.com

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Imikhiqizo Ehlobene

Omaka bomkhiqizo

Incazelo:

Ukunikezela Komkhiqizi Ngokuhlanzeka Okuphezulu kanye Nekhwalithi Ezinzile
Igama Lekhemikhali: Lopinavir
CAS: 192725-17-0
I-Peptidomimetic HIV-1 Protease Inhibitor Enamandla Kakhulu, Ekhethiwe
Umkhiqizo Wocwaningo Oluhlobene ne-COVID-19
Ikhwalithi ephezulu ye-API, Ukukhiqiza Kwezentengiso

Chemical Properties:

Igama Lekhemikhali	I-Lopinavir
Omqondofana	I-LPV;I-ABT-378;Kaletra
Inombolo ye-CAS	192725-17-0
Inombolo yeCAT	I-RF-API73
Isimo Sesitoko	Esitokweni, Isikali Sokukhiqiza Sifika Emakhulwini Amakhilogremu
I-Molecular Formula	I-C37H48N4O5
Isisindo samangqamuzana	628.81
Isitoreji Sesikhathi Eside	Gcina Isikhathi Eside ku-2-8℃
Ibhrendi	I-Ruifu Chemical

Imininingwane:

Into	Imininingwane
Ukubukeka	Impushana Emhlophe Kuya Kumhlophe
Ukuncibilika	I-Soluble Ngokukhululekile ku-Methanol naku-Ethanol, I-Soluble ku-2-Propanol
Ukuhlonza IR	I-spectrum yokumuncwa kwe-infrared yesampula yokuhlola ihambisana ne-spectrum yezinga lereferensi
Ukuhlonza HPLC	Isikhathi sokugcinwa kwesampula yokuhlola sihambisana naleso sezinga lesithenjwa
Okuqukethwe kwamanzi (nge-KF)	≤4.0%
I-Specific Optical Rotation	-22.0° ukuze -26.0°
Izinsalela ekushiseni	≤0.20%
Izinsimbi Ezisindayo	≤20ppm
I-Melting Point	124.0 ukuze 127.0 ℃
Umlotha one-sulphate	≤0.20%
I-Residual Solvent (Ethanol)	≤0.50%
Izinto Ezihlobene	(HPLC, Area%)
Ukungcola 1
Ukungcola B (RRT=0.07)	≤0.20%
Ukungcola I (RRT=1.10)	≤0.20%
Noma Ikuphi Okunye Ukungcola	≤0.10%
Ukungcola 2	Noma Ikuphi Okunye Ukungcola Komuntu Ngamunye ≤0.10%
Ukungcola Okuphelele Kwenqubo 1 kanye No-2	≤0.70%
Ukungcola Okuphelele	≤1.0%
I-Assay (nge-HPLC)	98.0%~102.0%
Izinga Lokuhlola	I-Enterprise Standard
Ukusetshenziswa	I-Peptidomimetic HIV-1 Protease Inhibitor, Umkhiqizo Wocwaningo Oluhlobene ne-COVID-19

Iphakheji nesitoreji:

Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, isigubhu seCardboard, 25kg/Drum, noma ngokwezidingo zekhasimende.

Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni, umswakama kanye nezinambuzane.

Izinzuzo:

I-FAQ:

Isicelo:

I-Lopinavir (ABT-378) iyi-peptidomimetic inhibitor enamandla kakhulu, ekhethayo ye-HIV-1 protease, ene-Kis engu-1.3 kuya ku-3.6 pM yohlobo lwasendle kanye ne-HIV protease eguquguqukayo.I-Lopinavir isebenza ngokunqanda ukuvuthwa kwe-HIV-1 ngaleyo ndlela ivimbe ukungatheleleki kwayo.I-Lopinavir iphinde ibe yi-SARS-CoV 3CLpro inhibitor ene-IC50 ye-14.2 μM.I-Lopinavir iyi-antiretroviral yesigaba se-protease inhibitor.Ukuvinjelwa kwe-HIV-1 protease kuvimbela ukuqhekeka kwe-viral polyprotein precursor futhi kuphumela ekukhululweni kwama-virion angavuthiwe, angatheleleki.Ingxenye yokwelapha okuyinhlanganisela yokwelapha i-HIV/AIDS.I-Lopinavir, inhibitor yesithupha ye-HIV protease inhibitor esigabeni “se-navir”, yethulwa ngokuhambisana ne-ritonavir, enye i-HIV protease inhibitor esivele imakethwa (Abbott, 1996);lokhu kwakhiwa kwasekuqaleni kwethulwa njenge-Kaletra ukuze kusetshenziswe ngokuhambisana ne-nucleoside noma i-non-nucleoside reverse transcriptase inhibitors yokwelapha ingculaza kubantu abadala nasezinganeni.I-Lopinavir iyinhlanganisela ye-peptidomimetic enomongo wesakhiwo ofana naleyo ye-ritonavir, lapho amaqembu abulalayo, ikakhulukazi i-valine eshintshiwe, yethulwa ngezinqubo zokuhlanganisa i-peptide.I-Lopinavir iyi-inhibitor enamandla yokuncintisana ye-HIV-I protease ebonisa amandla aphezulu ngokumelene nezinguquko ezimelana ne-ritonavir.Ezinhlotsheni zezilwane ezimbalwa, izifundo ze-pharmacokinetic nenhlangano ye-lopinavirlritonavir zibonise ukuthi izakhiwo ezinesizotha ze-lopinavir zathuthukiswa kakhulu lapho kukhona i-ritonavir, ngokuya nge-Cmax kanye nobude besikhathi sokusebenza.