I-Losartan Potassium CAS 124750-99-8 API Factory Antihypertensive High Purity
Nikeza i-Losartan Potassium kanye Nezixhumanisi Ezihlobene Nekhwalithi Ephezulu
I-Losartan Potassium CAS 124750-99-8
I-2-Butyl-4-Chloro-5-Formylimidazole (BCFI) CAS 83857-96-9
Igama Lekhemikhali | I-Losartan Potassium |
Omqondofana | I-DUP 753;I-Cozaar;2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl]imidazole-5-methanol Potassium Usawoti |
Inombolo ye-CAS | 124750-99-8 |
Inombolo yeCAT | I-RF-API98 |
Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani |
I-Molecular Formula | I-C22H22ClKN6O |
Isisindo samangqamuzana | 461.01 |
I-Melting Point | 263.0~265.0℃ |
Ukuncibilika | Incibilika Ngokukhululekile Emanzini naku-Methanol, Incibilika Kancane ku-Acetonitrile. |
Ibhrendi | I-Ruifu Chemical |
Into | Imininingwane |
Ukubukeka | I-Crystalline Powder Emhlophe noma Cishe Emhlophe |
Ukuhlonza A | Ukumuncwa kwe-infrared: Kumelwe Kufane Nezinga Lereferensi |
Ukuhlonza B | Ukumuncwa kwe-Ultraviolet: Kumele Kufane Nezinga Lereferensi |
Ukuhlolwa kwe-Potassium | Kumele kube Positive |
Okuqukethwe kwamanzi (KF) | ≤0.50% |
Izinsimbi Ezisindayo | ≤10ppm |
Izinto Ezihlobene (HPLC) | |
Noma yikuphi Ukungcola Komuntu Ngamunye | ≤0.20% |
Ukungcola Okuphelele | ≤0.50% |
I-Residual Solvents (GC) | |
I-Cyclohexane | ≤0.10% |
Isopropyl Utshwala | ≤0.20% |
Indlela Yokuhlola/Yokuhlaziya | 98.5~101.0% (HPLC, ibalwa ngesisekelo se-anhydrous, i-solvent-free) |
I-N-Nitrosodiethylamine | ≤0.177ppm (NDEA) |
I-N-Nitrosodimethylamine | ≤0.640ppm (NDMS) |
Usayizi Wezinhlayiyana | 90% Ngaphansi Kwama-Microns angama-38 |
I-Shelf Life | Izinyanga ezingama-24 |
Izinga Lokuhlola | I-Enterprise Standard |
Ukusetshenziswa | I-API, i-Angiotensin II Receptor Antagonist I-Antihypertensive |
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, isigubhu seCardboard, 25kg/Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni, umswakama kanye nezinambuzane.
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I-Losartan Potassium iyimbangi yokuqala enamandla futhi ekhethayo engeyona i-peptide i-angiotensin II receptor uhlobo 1 (AT1) eyethulwe emakethe njenge-antihypertensive yomlomo kanye ngosuku.Ukugxila okuvimbela u-50% wokubopha i-angiotensin II (IC50) ngu-20 nM.I-Losartan (40 μM) ithinta i-ISC kodwa ivimbela umphumela we-ANGII ku-ISC.I-Losartan inciphisa kakhulu ukwanda kwe-Ang II-mediated cell kumaseli omdlavuza we-endometrial.Inhlanganisela ye-losartan ne-anti-miR-155 inomphumela omkhulu kakhulu we-antiproliferative uma kuqhathaniswa nomuthi ngamunye kuphela.I-metabolized ukukhiqiza i-5-carboxylic acid metabolite (EXP3174) futhi kubikwa ukuthi yehlisa umfutho wegazi.Njengamanje isacwaningwa njengendlela yokwelapha engaba khona ye-COVID-19 ukuze ikwazi ukunciphisa noma ukudambisa izimpawu ze-COVID-19.
1. Ukwelashwa komfutho wegazi ophakeme obalulekile, ingasetshenziswa iyodwa noma ihlanganiswe nezinye izidakamizwa ze-antihypertensive (njenge-diuretics).2. Ukwelapha ukuhluleka kwenhliziyo, ingasetshenziswa iyodwa noma ihlanganiswe nezidakamizwa ze-cardiotonic noma i-diuretic Chemicalbook.3. Ukuvimbela isifo sohlangothi ezigulini ezine-hypertension kanye ne-left ventricular hypertrophy.4. Isetshenziselwa ukwehlisa ukuqhubekela phambili kwe-nephropathy ezigulini ezinesifo sikashukela sohlobo 2 oluhambisana ne-nephropathy kanye nomfutho wegazi ophakeme.