I-Methyl 4-(Bromomethyl)-3-Methoxybenzoate CAS 70264-94-7 Zafirlukast Intermediate
Ukunikezwa Komkhiqizi, Ukuhlanzeka Okuphezulu, Ukukhiqizwa Kwezohwebo
Igama Lekhemikhali: Methyl 4-(Bromomethyl)-3-Methoxybenzoate
I-CAS: 70264-94-7
Igama Lekhemikhali | I-Methyl 4-(Bromomethyl)-3-Methoxybenzoate |
Omqondofana | 4-(Bromomethyl) -3-methoxybenzoic Acid Methyl Ester;I-Methyl 4-(Bromomethyl)-m-anisate;4-(Bromomethyl)-m-anisic Acid Methyl Ester |
Inombolo ye-CAS | 70264-94-7 |
Inombolo yeCAT | I-RF-PI437 |
Isimo Sesitoko | Kukhona kusitoki |
I-Molecular Formula | I-C10H11BrO3 |
Isisindo samangqamuzana | 259.10 |
I-Melting Point | 92.0 ukuze 94.0℃ |
Ukuminyana | 1.432 |
Ibhrendi | I-Ruifu Chemical |
Into | Imininingwane |
Ukubukeka | Impushana Ephuzi Ephaphathekile |
Indlela Yokuhlola / Yokuhlaziya | ≥98.0% (HPLC) |
Ukulahlekelwa Ekumisweni | ≤1.0% |
Izinsalela ekushiseni | ≤0.50% |
Ukungcola Okuphelele | ≤2.0% |
Izinsimbi Ezisindayo | ≤20ppm |
Izinga Lokuhlola | I-Enterprise Standard |
Ukusetshenziswa | I-Intermediate of Zafirlukast (CAS: 107753-78-6), Isetshenziswa njenge-antiasthmatic |
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni nakumswakama.
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I-Methyl 4-(Bromomethyl)-3-Methoxybenzoate (CAS 70264-94-7) isetshenziswa njengendawo ephakathi ye-Zafirlukast (CAS: 107753-78-6).I-Zafirlukast iyimbangi ye-lys-LTs yomlomo ekhetha kakhulu futhi ethatha isikhathi eside.I-leukotrienes idlala indima ebalulekile ku-pathogenesis ye-asthma.Lezi zinto zingama-peptide, ezikwazi ukubopha ngokukhetha ku-LTC4, LTD4 kanye ne-LTE4 receptor ngokuphikisana nomphumela wayo, ukwehlisa izimpawu zesifuba somoya kanye nokwenza ngcono ukusebenza kwamaphaphu.Lo mkhiqizo womabili uyisisetshenziswa esivimbela ukuvuvukala okubangelwa isifuba somoya (iphikisana nomsebenzi we-leukotriene proinflammatory) kanye nomuthi wokusiza wesifuba somoya (i-bronchial asthma) (ungaphikisani nokufinyezwa kwemisipha ebushelelezi ye-leukotriene).Ukusetshenziswa kwalo mkhiqizo akuguquli ukusabela kwemisipha ebushelelezi kuma-β2 receptors futhi kusebenza kahle ekwelapheni i-bronchoconstriction ebangelwa i-antigen, i-aspirin, ukuvivinya umzimba nomoya obandayo, ukwazi ukunciphisa umthamo we-hormone kanye ne-β2 receptor agonist.
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