I-Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propanoate CAS 328086-60-8 PF-07321332 Boceprevir Isithombe Esimaphakathi Esifakiwe

I-Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propanoate CAS 328086-60-8 PF-07321332 Boceprevir Intermediate

Incazelo emfushane:

Igama Lekhemikhali: I-Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propanoate

I-CAS: 328086-60-8

Ukubukeka: Impushana Emhlophe ukuya Emhlophe

Okumaphakathi kwe-PF-07321332 Paxlovid (CAS 2628280-40-8) kanye ne-Boceprevir (CAS 394730-60-0)

Ikhwalithi Ephezulu, Ukukhiqizwa Kwezohwebo

Inquiry: alvin@ruifuchem.com

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Imikhiqizo Ehlobene

Omaka bomkhiqizo

Incazelo:

I-Commercial Supply PF-07321332 I-Paxlovid Izixhumanisi Ezihlobene Nekhwalithi Ephezulu
I-L-tert-Leucine (H-Tle-OH) CAS 20859-02-3
I-Caronic Anhydride CAS 67911-21-1
(1R,2S,5S)-6,6-Dimethyl-3-azabicyclo[3.1.0]hexane-2-Carboxylic Acid Methyl Ester Hydrochloride 565456-77-1
I-Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propanoate CAS 328086-60-8
6,6-Dimethyl-3-azabicyclo[3.1.0]hexane CAS 943516-54-9

Chemical Properties:

Igama Lekhemikhali	I-Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propanoate
Omqondofana	I-Methyl (S)-2-((tert-butoxycarbonyl)amino)-3-((S)-2-oxopyrrolidin-3-yl)propanoate;(αS,3S) -α--[(tert-Butyloxycarbonyl)aMino]-2-oxo-3-pyrrolidinepropanoic acid i-Methyl Ester;(S)-Methyl 2-((tert-butoxycarbonyl)amino)-3-((S)-2-oxopyrrolidin-3-yl)propanoate
Inombolo ye-CAS	328086-60-8
Inombolo yeCAT	I-RF-PI317
Isimo Sesitoko	Esitokweni, Isikali Sokukhiqiza Sifika Emakhulwini Amakhilogremu
I-Molecular Formula	I-C13H22N2O5
Isisindo samangqamuzana	286.33
Ibhrendi	I-Ruifu Chemical

Imininingwane:

Into	Imininingwane
Ukubukeka	Impushana Emhlophe Kuya Kumhlophe
Ukuhlonza A	I-IR: Ifana Nereferensi Into
Ukuhlonza B	Isikhathi Sokugcina: Sifana Nereferensi Into
Ukulahlekelwa Ekumisweni	≤1.0%
Izinsalela ekushiseni	≤0.20%
Ukungcola Okukodwa	≤0.50%
Ukungcola Okuphelele	≤2.0%
Izinsimbi Ezisindayo (Pb)	≤20ppm
Ubumsulwa	≥98.0%
Izinga Lokuhlola	I-Enterprise Standard
Ukusetshenziswa	Okumaphakathi kwe-PF-07321332 Paxlovid (CAS 2628280-40-8) kanye ne-Boceprevir (CAS 394730-60-0)

Iphakheji nesitoreji:

Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, isigubhu seCardboard, 25kg/Drum, noma ngokwezidingo zekhasimende.

Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni, umswakama kanye nezinambuzane.

Izinzuzo:

I-FAQ:

Isicelo:

I-Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propanoate (CAS 328086-60-8) iphakathi kwe-PF-07321332 Paxlovid (CAS 2628280-40 -8) kanye ne-Boceprevir (CAS 394730-60-0).I-PF-07321332, ingxenye ebalulekile ye-Paxlovid (PF-07321332 kanye ne-Ritonavir) okuyikhandidethi lokuphenywa le-COVID-19 ngomlomo, iyi-3C-like protease (3CLPRO) inhibitor etholakala ngomlomo enemiphumela enamandla yokulwa namagciwane ngokumelene negciwane le-SARS-CoV-2. kanye ne-COVID-19.NgoNovemba 6 2021, u-Pfizer umemezele ukuthi u-Paxlovid wehlise kakhulu ukulaliswa esibhedlela nokufa, ngokusekelwe ekuhlaziyweni kwesikhashana kwe-Phase 2/3 EPIC-HR (Ukuhlola Ukuvinjelwa Kwe-Protease kwe-COVID-19 ku-High-Risk Patients) ucwaningo olungahleliwe, olungaboni kabili. yeziguli zabantu abadala ezingalaliswa esibhedlela ezine-COVID-19, ezisengozini enkulu yokudlulela ekuguleni okunzima.I-Boceprevir (EBP-520) iyi-HCV protease inhibitor (Ki=14 nM) yokwelapha ukutheleleka ngegciwane le-hepatitis C.I-Boceprevir ene-pegylated interferon kanye ne-ribavirin (i-PegIFN/RBV) inikeze amandla ukuthuthukiswa kumazinga okuphendula okuqhubekayo kwe-virological yeziguli ezine-genotype 1 HCV.I-Boceprevir isebenzisana ne-immunosuppressive therapy (IT) ngokuvimbela i-cytochrome P450 3A enzyme.