N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1 Purity >99.0% (HPLC) I-Afatinib Dimaleate Intermediate Factory

Incazelo emfushane:

Igama Lekhemikhali: N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine

I-CAS: 162012-67-1

Ubumsulwa: >99.0% (HPLC)

Ukubukeka: Impushana Ephuzi Ngokukhanyayo ukuya Ephuzi

I-Intermediate ye-Afatinib Dimaleate (CAS: 850140-73-7)

E-Mail: alvin@ruifuchem.com

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Imikhiqizo Ehlobene

Omaka bomkhiqizo

Incazelo:

I-Ruifu Chemical Supply Intermediates ye-Afatinib
I-Afatinib CAS 439081-18-2
I-Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(I-Dimethylamino)i-acetaldehyde I-Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
I-Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-one CAS 162012-69-3
I-7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineI-CAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineI-CAS 314771-88-5

Chemical Properties:

Igama Lekhemikhali	N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine
Omqondofana	I-N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitro-4-Quinazolinamine;(3-Chloro-4-Fluorophenyl)(7-Fluoro-6-Nitroquinazolin-4-yl)amine;4-(3-Chloro-4-Fluoroanilino)-7-Fluoro-6-Nitroquinazoline;I-Afatinib Intermediate A
Inombolo ye-CAS	162012-67-1
Inombolo yeCAT	I-RF-PI2026
Isimo Sesitoko	Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani
I-Molecular Formula	I-C14H7ClF2N4O2
Isisindo samangqamuzana	336.68
Ukuzwela	Izwela Umoya, Izwela Ukushisa
I-Melting Point	242.0~244.0℃
Iphuzu elibilayo	489℃
Ukuminyana	1.616
Ibhrendi	I-Ruifu Chemical

Imininingwane:

Into	Imininingwane
Ukubukeka	Impushana Ephuzi Ekhanyayo ukuya Ephuzi
Ukuhlanzeka / Indlela Yokuhlaziya	>99.0% (HPLC)
Ukulahlekelwa Ekumisweni	<0.50%
Izinsalela ekushiseni	<0.20%
Izinto Ezihlobene
Ukungcola Ngamunye	<0.50%
Ukungcola Okuphelele	<1.00%
Izinsimbi Ezisindayo	≤20ppm
I-Infrared Spectrum	Ivumelana Nesakhiwo
I-Proton NMR Spectrum	Ivumelana Nesakhiwo
Izinga Lokuhlola	I-Enterprise Standard
Ukusetshenziswa	I-Intermediate ye-Afatinib Dimaleate (CAS: 850140-73-7)

Iphakheji nesitoreji:

Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwemfuneko yekhasimende

Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni nakumswakama

Izinzuzo:

I-FAQ:

Isicelo:

I-N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine (CAS: 162012-67-1) iphakathi ekuhlanganiseni kwe-Afatinib Dimaleate (CAS: 850140-73-7) .I-Afatinib Dimaleate uhlobo lukasawoti lwe-Afatinib.I-Afatinib iyisizukulwane sesibili, esilawulwa ngomlomo, inhibitor engenakuhlehla yomndeni wakwa-ErbB we-tyrosine kinases.Indlela Yokwenza I-Afatinib yehlisa ukusayinda kwe-ErbB ngokubophezela ngokuhlanganyela ezizindeni ze-kinase ze-epidermal growth factor receptor (EGFR), i-human epidermal growth factor receptor (HER) 2 kanye ne-HER4, okuholela ekuvinjweni okungenakuhlehliswa kwe-tyrosine kinase autophosphorylation;iphinde ivimbele i-transphosphorylation ye-HER3.I-Afatinib ivunyiwe njenge-monotherapy yokwelashwa kwe-EGFR tyrosine kinase inhibitor (TKI) -abadala abangenalwazi abanezinga eliphezulu lendawo noma I-DefinitionChEBI: Usawoti we-maleate otholwe ngokuhlanganisa i-afatinib nezilinganiso ezimbili ze-molar ze-maleic acid.Isetshenziselwa ukwelashwa komugqa wokuqala kweziguli ezinomdlavuza wamaphaphu we-metastatic ongewona omncane.