I-N-Hydroxysuccinimide (HOSu) CAS 6066-82-6 Coupling Reagent Purity >99.0% (HPLC)

Incazelo emfushane:

Igama Lekhemikhali: N-Hydroxysuccinimide

Omqondofana: HOSu;I-NHS

I-CAS: 6066-82-6

Ubumsulwa: >99.0% (HPLC)

Ukubukeka: I-Crystalline Powder Emhlophe

I-Coupling Reagent ye-Peptide, Ikhwalithi Ephezulu

Thintana: UDkt. Alvin Huang

Iselula/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Imikhiqizo Ehlobene

Omaka bomkhiqizo

Incazelo:

I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi ohamba phambili we-N-Hydroxysuccinimide (HOSu) (CAS: 6066-82-6) enekhwalithi ephezulu.I-Ruifu Chemical ihlinzeka ngochungechunge lwama-reagents avikelayo kanye nama-reagents ahlanganisayo.I-Ruifu inganikeza ukulethwa komhlaba wonke, intengo encintisanayo, amanani amancane nayinqwaba atholakalayo.Thenga i-N-Hydroxysuccinimide,Please contact: alvin@ruifuchem.com

Chemical Properties:

Igama Lekhemikhali	I-N-Hydroxysuccinimide
Omqondofana	I-HOSu;I-NHS;1-Hydroxysuccinimide;I-1-Hydroxy-2,5-Pyrrolidinedione;I-N-Hydroxy-2,5-dioxopyrrolidine
Isimo Sesitoko	In Stock, Mass Production
Inombolo ye-CAS	6066-82-6
I-Molecular Formula	C4H5NO3
Isisindo samangqamuzana	115.09 g/mol
I-Melting Point	93.0~98.0℃(lit.)
Ukuminyana	1.649
Kuyazwela	I-Hygroscopic.Kuyazwela Ukushisa, Kuyazwela Umswakama
I-Solubility ku-Dioxane	Incibilika ku-Dioxane, Icishe Ikhanye
Ukuncibilika Emanzini	Incibilika Emanzini
Isikhathi Sokugcina.	Indawo epholile neyomile (2~8℃)
I-COA ne-MSDS	Iyatholakala
Isigaba	Ama-Reagents wokuhlanganisa
Ibhrendi	I-Ruifu Chemical

Imininingwane:

Izinto	Amazinga Wokuhlola	Imiphumela
Ukubukeka	I-Crystalline Powder Emhlophe	Iyahambisana
I-Melting Point	93.0~98.0℃	94.0~97.0℃
Ukulahlekelwa Ekumisweni	<0.50%	0.15%
Ukuhlanzeka / Indlela Yokuhlaziya	>99.0% (HPLC)	99.5%
I-Infrared Spectrum	Ivumelana Nesakhiwo	Iyahambisana
I-Proton NMR Spectrum	Ivumelana Nesakhiwo	Iyahambisana
Isiphetho	Umkhiqizo uhloliwe futhi uthobelana nezicaciso

Indlela Yokuhlola:

Isigaba seselula: 0.1% isisombululo se-phosphoric acid: i-acetonitrile =90:10
Ubude begagasi: 220nm
Izinga lokugeleza: 1ml/min

Iphakheji/Isitoreji/Ukuthumela ngomkhumbi:

Iphakheji:Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Ukuzwela umswakama.Gcina ezitsheni ezivaliwe endaweni epholile neyomile (2~8℃) kude nezinto ezingahambelani.Vikela ekukhanyeni nakumswakama.
Ukuthumela:Thumela emhlabeni wonke nge-FedEx / DHL Express.Nikeza ukulethwa okusheshayo nokuthembekile.

Izinzuzo:

Amandla Anele: Izinsiza ezanele kanye nochwepheshe

Isevisi Yobuchwepheshe: Isevisi yokuthenga yokuma eyodwa

Iphakheji le-OEM: Iphakheji yangokwezifiso kanye nelebula iyatholakala

Ukulethwa Okusheshayo: Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe

Impahla Ezinzile: Gcina isitoko esinengqondo

Ukusekelwa Kwezobuchwepheshe: Isixazululo sezobuchwepheshe siyatholakala

Isevisi Yokuhlanganisa Ngokwezifiso: Isukela kumagremu kuye kumakhilo

Ikhwalithi Ephezulu: Kusungulwe uhlelo oluphelele lokuqinisekisa ikhwalithi

I-FAQ:

Indlela Yokuthenga?Sicela uxhumaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

Iminyaka engu-15 Yokuhlangenwe nakho?Sinesipiliyoni seminyaka engaphezu kwe-15 ekwakhiweni nasekuthumeleni kwamanye amazwe uhla olubanzi lwezinga eliphezulu lokuxhumanisa imithi noma amakhemikhali amahle.

Izimakethe Eziyinhloko?Thengisa emakethe yasekhaya, eNyakatho Melika, eYurophu, eNdiya, eKorea, eJapane, e-Australia, njll.

Izinzuzo?Ikhwalithi ephezulu, intengo ethengekayo, izinsizakalo ezichwepheshile nokusekelwa kobuchwepheshe, ukulethwa okusheshayo.

IkhwalithiIsiqiniseko?Isistimu yokulawula ikhwalithi eqinile.Imishini yobuchwepheshe yokuhlaziya ifaka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, NOMA, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njll.

Amasampula?Imikhiqizo eminingi inikeza amasampula wamahhala wokuhlolwa kwekhwalithi, izindleko zokuthumela kufanele zikhokhelwe amakhasimende.

Ukuhlolwa Kwemboni?Wamukelekile ekucwaningweni kwemboni.Sicela wenze i-aphoyintimenti kusengaphambili.

I-MOQ?Ayikho i-MOQ.I-oda elincane liyamukeleka.

Isikhathi sokuthumela? Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe.

Ezokuthutha?By Express (FedEx, DHL), by Air, by Sea.

Amadokhumenti?Ngemuva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njll.

Custom Synthesis?Ingahlinzeka ngezinsizakalo zokwenziwa ngokwezifiso ukuze zilingane kangcono nezidingo zakho zocwaningo.

Imigomo Yokukhokha?I-invoyisi ye-Proforma izothunyelwa kuqala ngemva kokuqinisekiswa kwe-oda, kufakwe nemininingwane yethu yasebhange.Inkokhelo nge-T/T (Telex Transfer), PayPal, Western Union, njll.

6066-82-6 - Ubungozi Nokuphepha:

Izimpawu Zengozi Xi - Iyacasula
Amakhodi Engozi
36/37/38 - Ukucasula amehlo, uhlelo lokuphefumula kanye nesikhumba.
Incazelo Yokuphepha
S22 - Ungaphefumuli uthuli.
I-S24/25 - Gwema ukuthintana nesikhumba namehlo.
S26 - Uma uthintana namehlo, geza ngokushesha ngamanzi amaningi futhi ufune iseluleko sezokwelapha.
I-S36 - Gqoka izingubo ezifanele zokuzivikela.
I-WGK Germany 3
TSCA Yebo
I-HS Code 2925190090
I-Hazard Note Irritant

Isicelo:

I-N-Hydroxysuccinimide (HOSu) (CAS: 6066-82-6), i-reagent yokulungiselela ama-esters asebenzayo ama-amino acid.I-ejenti exhumanisa i-peptide solid phase synthesis.
I-N-Hydroxysuccinimide ivamise ukusetshenziselwa ukusiza ukuhlangana kwe-peptide ye-carbodiimide-mediated ngokwenza i-ester esebenzayo emaphakathi ngokujiya kweqembu le-carboxyl elingaphezulu kanye ne-NHS.I-NHS-reactive ester intermediate isengozini yokuhlaselwa yi-nucleophilic ngama-amine ayinhloko futhi iphumela ekwakhekeni kwezibopho eziqinile ze-amide phakathi kwendawo ye-biomaterial kanye ne-N-terminus ye-peptide.
I-N-Hydroxysuccinimide iyi-succinimide eyi-hydroxylated esetshenziswa kakhulu ekwenzeni kusebenze ama-carboxylic acid ku-NHS-esters ukuze kuthuthukiswe ukuhlangana nama-nucleophile.Le ndlela ivame ukusetshenziswa kakhulu ekwenzeni kusebenze izinhlobo ze-asidi yamahhala ze-fluorophore ukuze kuthuthukiswe ukuhlangana kwalezi zinsalela zama-amine zamaphrotheni.Ukusetshenziswa kwe-NHS ester activation kubuye kwachazwa ekuhlanganisweni kwe-N-acyl amino acids.
Isetshenziselwa ukuhlanganiswa kwe-amino acid protectant, i-semi-synthetic kanamycin kanye ne-intermediates yezokwelapha.I-N-hydroxybutyldiimide kanye nokuphuma kwayo kuyizinto ezibalulekile zokusetshenziswa kwama-peptides, ama-antibiotics, ama-amino acid namaprotheni.I-N-hydroxybutyldiimide isetshenziswa ekulungiseleleni okusebenzayo okusebenzayo ama-esters, kanye nokuvinjwa komphumela osebenzayo wokuhlangana kwe-peptide kunezinhlobo eziningi ze-USES kwezokwelapha, futhi kuyisisekelo samakhemikhali asetshenziswayo.
I-N-Hydroxysuccinimide isetshenziselwa ama-amidations athuthukisiwe ngendlela ye-carbodiimide.Iphinde isetshenziselwe ukwenza kusebenze iqembu le-carboxyl futhi ihlangana ne-amine ukwenza i-amide.Ibandakanyeka ekulungiseni i-N-hydroxymaleimide-styrene copolymer.

Indlela Yokukhiqiza:

I-N-Hydroxysuccinimide yalungiswa ngale ndlela elandelayo: 100g (1.0mol) succinic anhydride kanye nama-70g (1.0mol) we-hydroxylamine hydrochloride ashiselwa ndawonye, uhlelo lokusabela lugcinwa ngaphansi kwengcindezi engemihle ukuze kukhishwe ama-volatiles akhiqiziwe, futhi kushisisa ngokushesha ukuya ngaphezu kuka-125℃ , bese ikhuphuka kancane iye ku-160℃ ngemva kuka-1H.Ukushisisa kwamiswa futhi lapho izinga lokushisa lehla laya ku-125℃, ukusabela koketshezi kwathelelwa ku-diethyl ether futhi kwanyakaziswa ngamandla.Ngemuva kokuthi umkhiqizo usuphulukisiwe, ungqimba lwe-ether lwancishiswa, umkhiqizo oselashiwe washiswa ukuze ubiliswe ngo-400ml we-butanol, ukuhlunga okushisayo, futhi i-filtrate yapholiswa ngokushesha ku-0℃.Ngemuva kokuhlunga kwe-1H, amakristalu ahlanzwa ngokulandelana nge-butanol ne-diethyl ether, futhi umkhiqizo ongahluziwe otholiwe waphinda wahlungwa kusuka ku-ethyl acetate ukuze uthole u-50g womkhiqizo oqediwe ngesivuno esingu-44%.