I-N(4)-Hydroxycytidine CAS 3258-02-4 EIDD-1931 Ikhwalithi ephezulu ye-NHC
Nikeza Ngokuhlanzeka Okuphezulu kanye Nekhwalithi Ezinzile
Igama Lekhemikhali: N(4)-Hydroxycytidine;I-EIDD-1931 (NHC)
I-CAS: 3258-02-4
I-metabolite esebenzayo ye-Molnupiravir, i-COVID-19 inhibitor ethembisayo
| Igama Lekhemikhali | I-N(4)-I-Hydroxycytidine |
| Omqondofana | I-EIDD-1931 (NHC);I-β-D-N4-Hydroxycytidine |
| Inombolo ye-CAS | 3258-02-4 |
| Inombolo yeCAT | I-RF-PI309 |
| Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumakhilogremu |
| I-Molecular Formula | I-C9H13N3O6 |
| Isisindo samangqamuzana | 259.22 |
| I-Melting Point | 169.0 ~ 172.0℃ |
| Ukuncibilika | Incibilika ku-100 mM ku-DMSO naku-50 mM Emanzini |
| Ukuminyana | 1.93±0.1 g/cm3 |
| Ibhrendi | I-Ruifu Chemical |
| Into | Imininingwane |
| Ukubukeka | Impushana Emhlophe Kuya Kumhlophe |
| I-NMR | Ihambisana Nesakhiwo |
| Ukuhlanzeka / Indlela Yokuhlaziya | >98% (HPLC) |
| Ukulahlekelwa Ekumisweni | ≤1.0% |
| Ukungcola Okukodwa | ≤0.50% |
| Izinsimbi Ezisindayo | ≤20ppm |
| Izinga Lokuhlola | I-Enterprise Standard |
| Ukusetshenziswa | I-metabolite esebenzayo ye-Molnupiravir (EIDD-2801), i-COVID-19 inhibitor |
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, isigubhu seCardboard, 25kg/Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni, umswakama kanye nezinambuzane.
I-N(4)-Hydroxycytidine (EIDD-1931 , β-d-N4-hydroxycytidine, NHC, CAS 3258-02-4) iyi-metabolite esebenzayo ye-EIDD-2801, i-COVID-19 inhibitor ethembisayo.I-EIDD-1931 (NHC) inomsebenzi obanzi wokulwa namagciwane ngokumelene nama-coronavirus amaningi, okuhlanganisa i-SARS-CoV-2, i-MERS-CoV, i-SARS-CoV, kanye neqembu le-zoonotic elihlobene i-2b noma i-2c Bat-CoVs anesilinganiso se-IC50 sika-0.15 μM, kanye kwandisa amandla ngokumelene ne-coronavirus ephethe ukuguqulwa kokumelana ne-nucleoside analog inhibitor remdesivir.Kumagundane atheleleke nge-SARS-CoV noma i-MERS-CoV, kokubili ukuphathwa kwe-prophylactic kanye nokwelapha kwe-Molnupiravir (EIDD-2801), i-NHC-prodrug etholakala ngomlomo (β-D-N4-hydroxycytidine-5'-isopropyl ester), umsebenzi wamaphaphu othuthukisiwe. , kanye nokunciphisa titer yegciwane kanye nokuncipha kwesisindo somzimba.Ukuncipha kwesivuno se-MERS-CoV ku-vitro kanye ne-vivo kuhlotshaniswa nokwanda kokuguquka kwemvamisa ku-viral kodwa hhayi iseli ye-RNA yokusingatha, okusekela indlela ye-mutagenesis ebulalayo ku-CoV.Amandla e-NHC/EIDD-2801 ngokumelene nama-coronavirus amaningi kanye ne-oral bioavailability agqamisa ukusetshenziswa kwayo okungase kube isinqamuleli esisebenzayo sokulwa ne-SARS-CoV-2 namanye ama-zoonotic coronaviruses esizayo.
