I-Octreotide Acetate CAS 83150-76-9 Peptide Purity (HPLC) ≥98.0% API High Quality

I-Octreotide Acetate (i-Sandostatin) iyi-analogue ye-peptide yokwenziwa ye-hormone somatostatin, iyi-analogue ye-somatostatin esebenza isikhathi eside ekhonjiswe ukulawula izimpawu kumathumba e-acromegaly kanye ne-gastroenteropancreatic.Okunye okungase kusetshenziswe ngaphansi kophenyo kubandakanya isifo sikashukela, i-psoriasis nesifo i-Alzheimer's.I-Octreotide Acetate (i-Sandostatin) iyi-analogue ye-peptide yokwenziwa ye-hormone somatostatin.Izenzo zayo zihlanganisa ukuvimbela ukukhiqizwa kwe-pituitary ye-hormone yokukhula kanye nokuvimbela ukukhiqizwa kwamaseli e-pancreatic islet we-insulin ne-glucagon.Ngokungafani ne-somatostatin, enesigamu sempilo ye-plasma yemizuzu embalwa, i-Octreotide ine-plasma yokuqeda isigamu sempilo yehora eli-1 kuye kwayi-2.Ukukhishwa komuthi ngokuyinhloko kuyizinso.I-Octreotide inciphisa ukuhamba kwamathumbu futhi ivimbele ukufinyela kwesinye.

Izidakamizwa ze-Peptide i-Novartis Sandostatin (i-Octreotide Acetate), iwukwenziwa kokuphuma kwe-somatostatin octapeptide yemvelo, igcina umphumela we-pharmacological ofana nowe-somatostatin, futhi umphumela uhlala isikhathi eside.Izinkomba ze-Octreotide Acetate zihlanganisa i-acromegaly;Ukunciphisa izimpawu nezimpawu ezihlobene nokusebenza kwe-gastroenteropancreatic endocrine neoplasia;Futhi ukusebenza kahle ku-Carcinoid Tumors ethula nge-carcinoid syndrome, izimila ze-VIP, nama-glucagon tumors.Ngaphezu kwalokho, i-Octreotide Acetate ye-gastrinomas/Zollinger-Ellison syndrome (imvamisa ihlanganiswa ne-proton pump inhibitors noma i-H2 receptor blockers), i-Insulinomas (ukuvimbela ngaphambi kokuhlinzwa kwe-hypoglycemia kanye nokugcinwa koshukela wegazi ovamile), izinga elisebenzayo le-hormone yokukhula ekhulula isici sesimila cishe u-50%.

I-Octreotide Acetate isidakamizwa somshuwalense wezempilo kazwelonke we-Class B, okuphuma ku-octapeptide yemvelo yokwenziwa ye-somatostatin, uma kuqhathaniswa ne-somatostatin yemvelo, i-half-life ye-somatostatin ngokusobala inwetshiwe futhi inemiphumela efanayo yezokwelapha, okuhlanganisa ukuvinjelwa komsebenzi we-hormone yokukhula, ukuvimbela. I-asidi yesisu, i-enzyme ye-pancreatic, i-glucagon ne-insulin secretion, nokunciphisa ukugeleza kwegazi kwe-visceral, kwehla ukuhamba kwesisu.Uma kuqhathaniswa ne-somatostatin yomdabu, i-octreotide inohhafu wempilo ende, ikhetha kakhulu ukuvimbela ukukhiqizwa kwe-hormone yokukhula kunokuvimbela ukukhiqizwa kwe-insulin, futhi ayibangeli ukuphindaphinda kwe-hypersecretion ye-hormone.1, Ukulawula ukuhlinzwa noma ukwelashwa ngemisebe akukwazi ukulawula ngokwanele isifo ezigulini ezinezimpawu ze-acromegaly nokunciphisa i-hormone yokukhula yesiguli (GH) ye-insulin-like growth factor -1(1GF-1) amazinga e-plasma.I-Sandostatin ingase futhi isetshenziselwe ukwelapha iziguli ezine-acromegaly ezingakwazi noma ezingathandi ukuhlinzwa, noma ukwelapha iziguli nge-acromegaly ezingakatholi ukwelashwa ngemisebe.2. Ukuncishiswa kwezimpawu ezihambisana ne-functional gastroenteropancreatic (GEP) endocrine tumors ezifana ne-carcinoid tumors with carcinoid syndrome ukubonakaliswa.I-Sandostatin ayiwona umuthi wokulwa nomdlavuza futhi azelaphi lezi ziguli.3, Ukuvinjelwa kwezinkinga ngemuva kokuhlinzwa kwe-pancreatic.4, iziguli ze-cirrhosis zesibindi ezinokopha kwe-variceal esiswini-esophageal okubangelwa ukwelashwa okuphuthumayo, i-hemostasis nokuvimbela ukopha kabusha, i-Sandostatin kufanele ihlanganiswe ne-endoscopic sclerotherapy nokunye ukwelashwa okukhethekile.