I-Octreotide Acetate CAS 83150-76-9 Peptide Purity (HPLC) ≥98.0% API High Quality
I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi ohamba phambili we-Octreotide Acetate (CAS: 83150-76-9) enekhwalithi ephezulu.I-Ruifu Chemical ihlinzeka ngochungechunge lwama-peptide e-GMP.I-Ruifu inganikeza ukulethwa komhlaba wonke, intengo encintisanayo, amanani amancane nayinqwaba atholakalayo.Thenga i-Octreotide Acetate,Please contact: alvin@ruifuchem.com
Igama Lekhemikhali | I-Octreotide Acetate |
Omqondofana | I-SMS 201-995;Samilstin;I-Octreotide-LAR; |
Ukulandelana | I-D-Phe-c[Cys-Phe-D-Trp-Lys-Thr-Cys]-Thr-ol |
AMAMOTHEKA | [FCFWKTCT(Disulfide Bridge: Cys2-Cys7)] |
Inombolo ye-CAS | 83150-76-9 |
Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumakhilogremu |
I-Molecular Formula | I-C49H66N10O10S2 |
Isisindo samangqamuzana | 1019.24 |
I-Melting Point | >140℃(dec.) |
Ukuminyana | 1.39±0.10 g/cm3 |
Ukuncibilika | I-Soluble ku-Acetic Acid, i-DMSO, ne-Methanol |
Ukuzinza | I-Hygroscopic |
Isikhathi Sokugcina. | Indawo Epholile Neyomile (2~8℃).Isiqandisi |
Idokhumenti | I-COA, MS, HPLC, NMR, MSDS, njll. |
Isigaba | GMP Peptides |
I-WGK Germany | 3 |
Izidingo Zokuthumela | Izikhwama zeqhwa, Izikhwama zeDesiccant |
Ibhrendi | I-Ruifu Chemical |
Izinto | Amazinga Wokuhlola | Imiphumela |
Ukubukeka | Impushana Emhlophe | Impushana Emhlophe |
Ukuncibilika | Incibilika Emanzini noma i-1% I-Acetic Acid Ekugxileni kwe-≥1mg/ml ukunikeza Isixazululo Esingenambala Esicacile | Kuyavumelana |
Ukuhlaziywa kwe-Amino Acid (Nge-HPLC) | Thr: 0.7 ~ 1.1 | 0.9 |
Ama-Cys: 1.0 ~ 2.2 | 1.9 | |
Amagama: 0.9 ~ 1.3 | 1.1 | |
Phe: 1.8~2.2 | 1.9 | |
I-Thr-OL: 0.6 ~ 1.3 | 0.9 | |
Uhambo: 0.4~1.1 | 0.8 | |
I-Peptide Purity (Nge-HPLC) | ≥98.0% (nge-Area Integration) | 99.81% |
Izinto Ezihlobene (Nge-HPLC) | Ukungcola Okuphelele (%) ≤2.0% | 0.19% |
Ukungcola Okukodwa Okukhulu Okukodwa (%) ≤1.0% | 0.12% | |
Okuqukethwe kwe-Acetate (HPLC) | 5.0~12.8% | 9.6% |
Okuqukethwe kwamanzi (Karl Fischer) | ≤7.0% | 2.7% |
Okuqukethwe kwe-TFA (Karl Fischer) | ≤0.25% | 0.13% |
I-Specific Optical Rotation | -45.0°~-55.0° (C=0.5, 95% HAc) | -51.5° |
Isivivinyo | 95.0~105.0% (I-Anhydrous, I-Acetic Engenayo) | 99.0% |
Umsuka Womkhiqizo | Zokwenziwa | |
Ukunaka | Okokucwaninga Kuphela, Hhayi Okokusetshenziswa Komuntu | |
Isiphetho | Umkhiqizo uhloliwe futhi uthobelana nezicaciso | |
Ukusetshenziswa | GMP Peptides;I-Active Pharmaceutical Ingredient (API) |
Iphakheji:Isitsha sepulasitiki (esinikezelwe ukupakisha i-peptide) noma isitsha sengilazi, ubuningi ngokuya ngesidingo semininingwane yekhasimende.
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile (2~8℃) kude nezinto ezingahambelani.Vikela ekukhanyeni nakumswakama.
Ukuthumela:Thumela emhlabeni wonke nge-FedEx / DHL Express.Nikeza ukulethwa okusheshayo nokuthembekile.
I-Octreotide Acetate (i-Sandostatin) iyi-analogue ye-peptide yokwenziwa ye-hormone somatostatin, iyi-analogue ye-somatostatin esebenza isikhathi eside ekhonjiswe ukulawula izimpawu kumathumba e-acromegaly kanye ne-gastroenteropancreatic.Okunye okungase kusetshenziswe ngaphansi kophenyo kubandakanya isifo sikashukela, i-psoriasis nesifo i-Alzheimer's.I-Octreotide Acetate (i-Sandostatin) iyi-analogue ye-peptide yokwenziwa ye-hormone somatostatin.Izenzo zayo zihlanganisa ukuvimbela ukukhiqizwa kwe-pituitary ye-hormone yokukhula kanye nokuvimbela ukukhiqizwa kwamaseli e-pancreatic islet we-insulin ne-glucagon.Ngokungafani ne-somatostatin, enesigamu sempilo ye-plasma yemizuzu embalwa, i-Octreotide ine-plasma yokuqeda isigamu sempilo yehora eli-1 kuye kwayi-2.Ukukhishwa komuthi ngokuyinhloko kuyizinso.I-Octreotide inciphisa ukuhamba kwamathumbu futhi ivimbele ukufinyela kwesinye.
Izidakamizwa ze-Peptide i-Novartis Sandostatin (i-Octreotide Acetate), iwukwenziwa kokuphuma kwe-somatostatin octapeptide yemvelo, igcina umphumela we-pharmacological ofana nowe-somatostatin, futhi umphumela uhlala isikhathi eside.Izinkomba ze-Octreotide Acetate zihlanganisa i-acromegaly;Ukunciphisa izimpawu nezimpawu ezihlobene nokusebenza kwe-gastroenteropancreatic endocrine neoplasia;Futhi ukusebenza kahle ku-Carcinoid Tumors ethula nge-carcinoid syndrome, izimila ze-VIP, nama-glucagon tumors.Ngaphezu kwalokho, i-Octreotide Acetate ye-gastrinomas/Zollinger-Ellison syndrome (imvamisa ihlanganiswa ne-proton pump inhibitors noma i-H2 receptor blockers), i-Insulinomas (ukuvimbela ngaphambi kokuhlinzwa kwe-hypoglycemia kanye nokugcinwa koshukela wegazi ovamile), izinga elisebenzayo le-hormone yokukhula ekhulula isici sesimila cishe u-50%.
I-Octreotide Acetate isidakamizwa somshuwalense wezempilo kazwelonke we-Class B, okuphuma ku-octapeptide yemvelo yokwenziwa ye-somatostatin, uma kuqhathaniswa ne-somatostatin yemvelo, i-half-life ye-somatostatin ngokusobala inwetshiwe futhi inemiphumela efanayo yezokwelapha, okuhlanganisa ukuvinjelwa komsebenzi we-hormone yokukhula, ukuvimbela. I-asidi yesisu, i-enzyme ye-pancreatic, i-glucagon ne-insulin secretion, nokunciphisa ukugeleza kwegazi kwe-visceral, kwehla ukuhamba kwesisu.Uma kuqhathaniswa ne-somatostatin yomdabu, i-octreotide inohhafu wempilo ende, ikhetha kakhulu ukuvimbela ukukhiqizwa kwe-hormone yokukhula kunokuvimbela ukukhiqizwa kwe-insulin, futhi ayibangeli ukuphindaphinda kwe-hypersecretion ye-hormone.1, Ukulawula ukuhlinzwa noma ukwelashwa ngemisebe akukwazi ukulawula ngokwanele isifo ezigulini ezinezimpawu ze-acromegaly nokunciphisa i-hormone yokukhula yesiguli (GH) ye-insulin-like growth factor -1(1GF-1) amazinga e-plasma.I-Sandostatin ingase futhi isetshenziselwe ukwelapha iziguli ezine-acromegaly ezingakwazi noma ezingathandi ukuhlinzwa, noma ukwelapha iziguli nge-acromegaly ezingakatholi ukwelashwa ngemisebe.2. Ukuncishiswa kwezimpawu ezihambisana ne-functional gastroenteropancreatic (GEP) endocrine tumors ezifana ne-carcinoid tumors with carcinoid syndrome ukubonakaliswa.I-Sandostatin ayiwona umuthi wokulwa nomdlavuza futhi azelaphi lezi ziguli.3, Ukuvinjelwa kwezinkinga ngemuva kokuhlinzwa kwe-pancreatic.4, iziguli ze-cirrhosis zesibindi ezinokopha kwe-variceal esiswini-esophageal okubangelwa ukwelashwa okuphuthumayo, i-hemostasis nokuvimbela ukopha kabusha, i-Sandostatin kufanele ihlanganiswe ne-endoscopic sclerotherapy nokunye ukwelashwa okukhethekile.
Imiphumela emibi yalo mkhiqizo i-Abdominal Pain, i-abdominal distension, I-Diarrhea, i-steatorrhea;Ukwakheka kwe-Gallstone;Ukubekezelela i-glucose kunganciphisa noma kube kubi kakhulu esigabeni sokuqala sokwelashwa, bese kungathuthukiswa;Ukusetshenziswa kwesikhathi eside ngaphandle kokukhiqizwa kwe-antibody endo native, akuzange kube khona ukuphindaphinda okusobala noma ukusabela okubi lapho umuthi umiswa noma wehliswa ngokushesha.2~8 deg C ukuze ugcine isikhathi eside.