I-Octreotide Acetate CAS 83150-76-9 Peptide Purity (HPLC) ≥98.0% API High Quality

Incazelo emfushane:

Igama Lekhemikhali: I-Octreotide Acetate

I-CAS: 83150-76-9

Ukubukeka: Impushana Emhlophe

I-Peptide Purity (Nge-HPLC): ≥98.0%

Isilinganiso: 95% ~ 105%

I-Acromegaly kanye ne-Gastroenteropancreatic Tumors

Thintana: UDkt. Alvin Huang

Iselula/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


Imininingwane Yomkhiqizo

Imikhiqizo Ehlobene

Omaka bomkhiqizo

Incazelo:

I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi ohamba phambili we-Octreotide Acetate (CAS: 83150-76-9) enekhwalithi ephezulu.I-Ruifu Chemical ihlinzeka ngochungechunge lwama-peptide e-GMP.I-Ruifu inganikeza ukulethwa komhlaba wonke, intengo encintisanayo, amanani amancane nayinqwaba atholakalayo.Thenga i-Octreotide Acetate,Please contact: alvin@ruifuchem.com

Chemical Properties:

Igama Lekhemikhali I-Octreotide Acetate
Omqondofana I-SMS 201-995;Samilstin;I-Octreotide-LAR;
Ukulandelana I-D-Phe-c[Cys-Phe-D-Trp-Lys-Thr-Cys]-Thr-ol
AMAMOTHEKA [FCFWKTCT(Disulfide Bridge: Cys2-Cys7)]
Inombolo ye-CAS 83150-76-9
Isimo Sesitoko Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumakhilogremu
I-Molecular Formula I-C49H66N10O10S2
Isisindo samangqamuzana 1019.24
I-Melting Point >140℃(dec.)
Ukuminyana 1.39±0.10 g/cm3
Ukuncibilika I-Soluble ku-Acetic Acid, i-DMSO, ne-Methanol
Ukuzinza I-Hygroscopic
Isikhathi Sokugcina. Indawo Epholile Neyomile (2~8℃).Isiqandisi
Idokhumenti I-COA, MS, HPLC, NMR, MSDS, njll.
Isigaba GMP Peptides
I-WGK Germany 3
Izidingo Zokuthumela Izikhwama zeqhwa, Izikhwama zeDesiccant
Ibhrendi I-Ruifu Chemical

Imininingwane:

Izinto Amazinga Wokuhlola Imiphumela
Ukubukeka Impushana Emhlophe Impushana Emhlophe
Ukuncibilika Incibilika Emanzini noma i-1% I-Acetic Acid Ekugxileni kwe-≥1mg/ml ukunikeza Isixazululo Esingenambala Esicacile Kuyavumelana
Ukuhlaziywa kwe-Amino Acid (Nge-HPLC) Thr: 0.7 ~ 1.1 0.9
Ama-Cys: 1.0 ~ 2.2 1.9
Amagama: 0.9 ~ 1.3 1.1
Phe: 1.8~2.2 1.9
I-Thr-OL: 0.6 ~ 1.3 0.9
Uhambo: 0.4~1.1 0.8
I-Peptide Purity (Nge-HPLC) ≥98.0% (nge-Area Integration) 99.81%
Izinto Ezihlobene (Nge-HPLC) Ukungcola Okuphelele (%) ≤2.0% 0.19%
Ukungcola Okukodwa Okukhulu Okukodwa (%) ≤1.0% 0.12%
Okuqukethwe kwe-Acetate (HPLC) 5.0~12.8% 9.6%
Okuqukethwe kwamanzi (Karl Fischer) ≤7.0% 2.7%
Okuqukethwe kwe-TFA (Karl Fischer) ≤0.25% 0.13%
I-Specific Optical Rotation -45.0°~-55.0° (C=0.5, 95% HAc) -51.5°
Isivivinyo 95.0~105.0% (I-Anhydrous, I-Acetic Engenayo) 99.0%
Umsuka Womkhiqizo Zokwenziwa  
Ukunaka Okokucwaninga Kuphela, Hhayi Okokusetshenziswa Komuntu  
Isiphetho Umkhiqizo uhloliwe futhi uthobelana nezicaciso
Ukusetshenziswa GMP Peptides;I-Active Pharmaceutical Ingredient (API)

Iphakheji nesitoreji:

Iphakheji:Isitsha sepulasitiki (esinikezelwe ukupakisha i-peptide) noma isitsha sengilazi, ubuningi ngokuya ngesidingo semininingwane yekhasimende.
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile (2~8℃) kude nezinto ezingahambelani.Vikela ekukhanyeni nakumswakama.
Ukuthumela:Thumela emhlabeni wonke nge-FedEx / DHL Express.Nikeza ukulethwa okusheshayo nokuthembekile.

Izinzuzo:

1

I-FAQ:

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Isicelo:

I-Octreotide Acetate (i-Sandostatin) iyi-analogue ye-peptide yokwenziwa ye-hormone somatostatin, iyi-analogue ye-somatostatin esebenza isikhathi eside ekhonjiswe ukulawula izimpawu kumathumba e-acromegaly kanye ne-gastroenteropancreatic.Okunye okungase kusetshenziswe ngaphansi kophenyo kubandakanya isifo sikashukela, i-psoriasis nesifo i-Alzheimer's.I-Octreotide Acetate (i-Sandostatin) iyi-analogue ye-peptide yokwenziwa ye-hormone somatostatin.Izenzo zayo zihlanganisa ukuvimbela ukukhiqizwa kwe-pituitary ye-hormone yokukhula kanye nokuvimbela ukukhiqizwa kwamaseli e-pancreatic islet we-insulin ne-glucagon.Ngokungafani ne-somatostatin, enesigamu sempilo ye-plasma yemizuzu embalwa, i-Octreotide ine-plasma yokuqeda isigamu sempilo yehora eli-1 kuye kwayi-2.Ukukhishwa komuthi ngokuyinhloko kuyizinso.I-Octreotide inciphisa ukuhamba kwamathumbu futhi ivimbele ukufinyela kwesinye.

Izidakamizwa ze-Peptide i-Novartis Sandostatin (i-Octreotide Acetate), iwukwenziwa kokuphuma kwe-somatostatin octapeptide yemvelo, igcina umphumela we-pharmacological ofana nowe-somatostatin, futhi umphumela uhlala isikhathi eside.Izinkomba ze-Octreotide Acetate zihlanganisa i-acromegaly;Ukunciphisa izimpawu nezimpawu ezihlobene nokusebenza kwe-gastroenteropancreatic endocrine neoplasia;Futhi ukusebenza kahle ku-Carcinoid Tumors ethula nge-carcinoid syndrome, izimila ze-VIP, nama-glucagon tumors.Ngaphezu kwalokho, i-Octreotide Acetate ye-gastrinomas/Zollinger-Ellison syndrome (imvamisa ihlanganiswa ne-proton pump inhibitors noma i-H2 receptor blockers), i-Insulinomas (ukuvimbela ngaphambi kokuhlinzwa kwe-hypoglycemia kanye nokugcinwa koshukela wegazi ovamile), izinga elisebenzayo le-hormone yokukhula ekhulula isici sesimila cishe u-50%.

I-Octreotide Acetate isidakamizwa somshuwalense wezempilo kazwelonke we-Class B, okuphuma ku-octapeptide yemvelo yokwenziwa ye-somatostatin, uma kuqhathaniswa ne-somatostatin yemvelo, i-half-life ye-somatostatin ngokusobala inwetshiwe futhi inemiphumela efanayo yezokwelapha, okuhlanganisa ukuvinjelwa komsebenzi we-hormone yokukhula, ukuvimbela. I-asidi yesisu, i-enzyme ye-pancreatic, i-glucagon ne-insulin secretion, nokunciphisa ukugeleza kwegazi kwe-visceral, kwehla ukuhamba kwesisu.Uma kuqhathaniswa ne-somatostatin yomdabu, i-octreotide inohhafu wempilo ende, ikhetha kakhulu ukuvimbela ukukhiqizwa kwe-hormone yokukhula kunokuvimbela ukukhiqizwa kwe-insulin, futhi ayibangeli ukuphindaphinda kwe-hypersecretion ye-hormone.1, Ukulawula ukuhlinzwa noma ukwelashwa ngemisebe akukwazi ukulawula ngokwanele isifo ezigulini ezinezimpawu ze-acromegaly nokunciphisa i-hormone yokukhula yesiguli (GH) ye-insulin-like growth factor -1(1GF-1) amazinga e-plasma.I-Sandostatin ingase futhi isetshenziselwe ukwelapha iziguli ezine-acromegaly ezingakwazi noma ezingathandi ukuhlinzwa, noma ukwelapha iziguli nge-acromegaly ezingakatholi ukwelashwa ngemisebe.2. Ukuncishiswa kwezimpawu ezihambisana ne-functional gastroenteropancreatic (GEP) endocrine tumors ezifana ne-carcinoid tumors with carcinoid syndrome ukubonakaliswa.I-Sandostatin ayiwona umuthi wokulwa nomdlavuza futhi azelaphi lezi ziguli.3, Ukuvinjelwa kwezinkinga ngemuva kokuhlinzwa kwe-pancreatic.4, iziguli ze-cirrhosis zesibindi ezinokopha kwe-variceal esiswini-esophageal okubangelwa ukwelashwa okuphuthumayo, i-hemostasis nokuvimbela ukopha kabusha, i-Sandostatin kufanele ihlanganiswe ne-endoscopic sclerotherapy nokunye ukwelashwa okukhethekile.

83150-76-9 - Ukuphepha:

Imiphumela emibi yalo mkhiqizo i-Abdominal Pain, i-abdominal distension, I-Diarrhea, i-steatorrhea;Ukwakheka kwe-Gallstone;Ukubekezelela i-glucose kunganciphisa noma kube kubi kakhulu esigabeni sokuqala sokwelashwa, bese kungathuthukiswa;Ukusetshenziswa kwesikhathi eside ngaphandle kokukhiqizwa kwe-antibody endo native, akuzange kube khona ukuphindaphinda okusobala noma ukusabela okubi lapho umuthi umiswa noma wehliswa ngokushesha.2~8 deg C ukuze ugcine isikhathi eside.

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