I-Olmesartan Medoxomil CAS 144689-63-4 Purity >99.5% (HPLC) API Factory
I-Ruifu Chemical Supply Olmesartan Medoxomil Intermediate With Quality High:
4,5-Dimethyl-1,3-Dioxol-2-One (DMDO) CAS 37830-90-3
4-Chloromethyl-5-Methyl-1,3-Dioxol-2-One (DMDO-Cl) CAS 80841-78-7
I-Ethyl 4-(1-Hydroxy-1-Methylethyl)-2-Propyl-Imidazole-5-Carboxylate CAS 144689-93-0
I-Diethyl 2-Propyl-1H-Imidazole-4,5-Dicarboxylate CAS 144689-94-1
I-Trityl Olmesartan Ethyl Ester CAS 144690-33-5
I-Trityl Olmesartan Acid CAS 761404-85-7
I-N2-Trityl Olmesartan Acid CAS 752179-89-8
I-Trityl Olmesartan Medoxomil CAS 144690-92-6
I-Olmesartan Medoxomil CAS 144689-63-4
Igama Lekhemikhali | I-Olmesartan Medoxomil |
Omqondofana | 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H- imidazole-5-carboxylic Acid (5-Methyl-2-oxo-1,3-dioxol-4-yl) methyl Ester;I-CS-866 |
Inombolo ye-CAS | 144689-63-4 |
Inombolo yeCAT | I-RF-PI1730 |
Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani |
I-Molecular Formula | I-C29H30N6O6 |
Isisindo samangqamuzana | 558.60 |
I-Melting Point | 180 ℃ (dec.) |
Ukuncibilika kwamanzi | Ayincibiliki emanzini;Incibilika kancane ku-DMSO |
Ibhrendi | I-Ruifu Chemical |
Into | Imininingwane |
Ukubukeka | I-Cyrstalline Powder Emhlophe kuya Kucishe Emhlophe |
Ukuhlonza | I-IR, i-HPLC, i-UV: Kumele Ihambisane Nezinga Lereferensi |
Ukuhlanzeka / Indlela Yokuhlaziya | >99.5% (HPLC ku-Anhydrous and Solvent-Free Basis) |
Ukulahlekelwa Ekumisweni | <0.50% |
Izinsalela ekushiseni | <0.10% |
Izinto Ezihlobene | |
I-Olmesartan RRT 0.2 | <0.50% |
I-Olmesartan Medoxoil Inhlanganisela Ehlobene A. RRT 0.7 | <0.20% |
I-Olefinic Impurity RRT 1.6 | <0.50% |
I-N-Alkyl Ukungcola RRT 3.4 | <0.10% |
Noma Ikuphi Okunye Ukungcola | <0.10% |
Ukungcola Okuphelele | <0.50% |
Izinsimbi Ezisindayo (njenge-Pb) | <10ppm |
I-pH Yesixazululo (2%, W/V) | 4.5 kuye ku-6.5 |
Izinga Lokuhlola | Izinga lebhizinisi;I-USP Standard |
Ukusetshenziswa | I-API |
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwemfuneko yekhasimende
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni nakumswakama
I-Olmesartan Medoxomil (CS-866) (i-CAS: 144689-63-4) iwuhlobo olunamandla futhi olukhethayo lwe-angiotensin II (AT(1)) yokwamukela i-receptor ene-IC50 ye-66.2 μM., esetshenziswa ekwelapheni umfutho wegazi ophakeme.Isetshenziswa njenge-antihypertensive.I-Olmesartan isebenza ngokuvimbela ukuboshwa kwe-angiotensin II kuma-receptors e-AT1 emisipha yemithambo.Ngokuvimbela ukubopha esikhundleni sokuhlanganiswa kwe-angiotensin II, i-Olmesartan ivimbela impendulo engemihle yokulawula ekukhiqizweni kwe-renin.I-Olmesartan Medoxomil iwumuthi osetshenziswayo okhishwa i-esterified ku-metabolite esebenzayo, i-olmesartan.I-Olmesartan Medoxomil yethulwa e-US njenge-Benicar, ukwelashwa okulawulwa ngomlomo kwe-hypertension.