I-Olopatadine Hydrochloride Intermediate CAS 27710-82-3 Ubumsulwa >99.0% (HPLC)
Umhlinzeki Ohamba phambili we-Olopatadine Hydrochloride Intermediates
I-Olopatadine Hydrochloride CAS 140462-76-6
I-Isoxepac CAS 55453-87-7
[3-(Dimethylamino)propyl]triphenylphosphonium Bromide Hydrobromide CAS 27710-82-3
Please Contact: alvin@ruifuchem.com
| Igama Lekhemikhali | [3-(Dimethylamino)propyl]triphenylphosphonium Bromide Hydrobromide |
| Omqondofana | (3-Dimethylaminopropyl)triphenylphosphonium Bromide HBr |
| Inombolo ye-CAS | 27710-82-3 |
| Inombolo yeCAT | RF2698 |
| Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani |
| I-Molecular Formula | I-C23H28Br2NP |
| Isisindo samangqamuzana | 509.27 |
| I-Melting Point | 283.0~285.0℃ |
| Ukuzinza | I-Hygroscopic |
| Ukuncibilika | I-Chloroform (Kancane), i-Methanol (Kancane) |
| Ibhrendi | I-Ruifu Chemical |
| Into | Imininingwane |
| Ukubukeka | I-Crystal Powder emhlophe ukuya kokumhlophe |
| Ukuhlanzeka / Indlela Yokuhlaziya | >99.0% (HPLC) |
| Indlela Yokuhlola / Yokuhlaziya | >99.0% (Titration) |
| Ukulahlekelwa Ekumisweni | <0.50% |
| Ukungcola Okukodwa | <0.50% |
| Ukungcola Okuphelele | <1.00% |
| 1 H NMR Spectrum | Ihambisana Nesakhiwo |
| Izinga Lokuhlola | I-Enterprise Standard |
| Ukusetshenziswa | Okumaphakathi kwe-Olopatadine Hydrochloride (CAS: 140462-76-6) |
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Izinzuzo?Ikhwalithi ephezulu, intengo ethengekayo, izinsizakalo ezichwepheshile nokusekelwa kobuchwepheshe, ukulethwa okusheshayo.
IkhwalithiIsiqiniseko?Isistimu yokulawula ikhwalithi eqinile.Imishini yobuchwepheshe yokuhlaziya ifaka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, NOMA, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njll.
Amasampula?Imikhiqizo eminingi inikeza amasampula wamahhala wokuhlolwa kwekhwalithi, izindleko zokuthumela kufanele zikhokhelwe amakhasimende.
Ukuhlolwa Kwemboni?Wamukelekile ekucwaningweni kwemboni.Sicela wenze i-aphoyintimenti kusengaphambili.
I-MOQ?Ayikho i-MOQ.I-oda elincane liyamukeleka.
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Amadokhumenti?Ngemuva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njll.
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[3-(Dimethylamino) propyl]triphenylphosphonium Bromide Hydrobromide (CAS: 27710-82-3) iphakathi kwe-Olopatadine Hydrochloride (CAS: 140462-76-6).I-Olopatadine Hydrochloride iyisidakamizwa esilwa nokungezwani komzimba.Inemiphumela emibili yokuvimbela ukukhululwa kwe-histamine kanye nama-receptors e-HI aphikisayo ngokukhethayo, futhi ayinakho ukuvinjelwa kwesistimu yezinzwa emaphakathi kanye nemiphumela engemihle yobuthi yenhliziyo evamile nezidakamizwa ezilwa nokungezwani ne-HI receptor.I-Olopatadine Hydrochloride ayikwazi nje ukuvimbela ukukhululwa kwe-histamine kuma-mast cells, kodwa futhi iphikisana nama-H1 receptors ngokukhetha, futhi ayinawo umthelela kuma-α adrenergic receptors, ama-dopamine receptors, nama-M1 kanye ne-M2 receptors.Phakathi kwabo, imiphumela emibi yesimiso sezinzwa esiphakathi imbalwa, isizukulwane esisha sezidakamizwa ezilwa nokuvuvukala ezikhethwayo.I-Olopatadine ingumphikisi onamandla, okhethayo we-H1 histamine receptor (Ki = 16-41.1 nM), ene-affinities ephansi kakhulu ye-H2 ne-H3 receptors (Ki = 43.4 kanye ne-172 μM, ngokulandelana).Ivimbela inzuzo ye-phosphoinositide eyenziwe nge-histamine kumaseli angawodwa (IC50 = 9.5-39.9 nM) futhi ivimbela i-anaphylaxis ye-cutaneous kumagundane (ED50 = 49 μg/kg) kanye ne-anaphylactic bronchoconstriction ezingulubeni (ID50 = 30 μg/kg).I-Olopatadine iyasebenza ekwelapheni i-rhinitis ye-allergic kanye ne-conjunctivitis.Iphinde icindezele i-itch ezigulini ezine-urticaria engapheli elawulwa kahle.Kubantu, le antihistamine ayikubangeli ukukhubazeka kwengqondo noma kwengqondo kumithamo yokwelapha.
