I-Palonosetron Hydrochloride CAS 135729-62-3 Purity >99.0% (HPLC) (T) Isithombe Esifakiwe Sefektri ye-API

I-Palonosetron Hydrochloride CAS 135729-62-3 Purity >99.0% (HPLC) (T) API Factory

Incazelo emfushane:

Igama Lekhemikhali: I-Palonosetron Hydrochloride

I-CAS: 135729-62-3

Ukubukeka: I-Crystalline Powder Emhlophe noma Engamhlophe

Ubumsulwa: >99.0% (HPLC) (T)

I-Palonosetron Hydrochloride inamandla kakhulu, ikhetha futhi iyasebenza ngomlomo i-5-HT3 receptor antagonist esetshenziswa ekuvimbeleni nasekwelapheni isicanucanu nokuhlanza okubangelwa ngamakhemikhali (i-CINV).I-Antiemetic.

Thintana: UDkt. Alvin Huang

Iselula/Wechat/WhatsApp: +86-15026746401

Inquiry: alvin@ruifuchem.com

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Imikhiqizo Ehlobene

Omaka bomkhiqizo

Incazelo:

I-Commercial Supply Palonosetron Hydrochloride kanye Nezixhumanisi Ezihlobene:
(S)-1,2,3,4-Tetrahydro-1-Naphthoic Acid CAS: 85977-52-2
(R)-1,2,3,4-Tetrahedro-1-Naphthoic Acid CAS: 23357-47-3
(S)-3-Aminoquinuclidine Dihydrochloride CAS: 119904-90-4
I-3-Quinuclidinone Hydrochloride CAS: 1193-65-3
I-1-Naphthoic Acid CAS: 86-55-5
I-Palonosetron Hydrochloride CAS: 135729-62-3 API

Chemical Properties:

Igama Lekhemikhali	I-Palonosetron Hydrochloride
Omqondofana	I-Palonosetron HCl;(S,S)-Palonosetron Hydrochloride;RS-25259;RS25259 197;(S)-2-((S)-Quinuclidin-3-yl)-2,3,3a,4,5,6-Hexahydro-1H-Benzo[de]isoquinolin-1-one Hydrochloride;(3aS)-2-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-Hexahydro-1H-benz[de]isoquinolin-1-one Hydrochloride ;I-Aloxi;I-Onicit
Inombolo ye-CAS	135729-62-3
Inombolo yeCAT	I-RF-API03
Isimo Sesitoko	Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani
I-Molecular Formula	I-C19H24N2O·HCl
Isisindo samangqamuzana	332.87
Isimo Okufanele Usigweme	Ukushisa Kuyazwela
I-Melting Point	307℃ (dec.)
Ukuncibilika Emanzini	Incibilika Ngokuphelele Emanzini
Ukuncibilika	Incibilika Kancane ku-Ethanol
Shipping Temperature	I-Ambient Temperature
I-COA ne-MSDS	Iyatholakala
Ibhrendi	I-Ruifu Chemical

Imininingwane:

Into	Imininingwane
Ukubukeka	I-Crystalline Powder Emhlophe noma Engamhlophe
I-Palonosetron Hydrochloride	>99.0% (HPLC) (T)
Ukuzungezisa Okuthile [α]20/D	-98.0°～-104.0°
Ukuhlonza	Engeza i-BiI7K4, Khiqiza Imvula Ephuzi Ewolintshi
Ukuhlonza	I-TLC Ihambisana Nezinto Eziyisethenjwa
Ukuhlonza	I-IR Ihambisana ne-IR Ejwayelekile
Ukuhlonza	Ukuhlonzwa njenge-Chloride
Ukuncibilika	Incibilika ngokukhululeka emanzini, incibilika kancane ku-Methanol, incibilika kancane ku-ethanol, ayincibiliki ku-acetone
Ukucaca kanye Nombala Wesixazululo	Ubukhulu.Isixazululo Esijwayelekile Sombala Ophuzi No. 2
I-pH Vaule	4.5~6.5 (10mg/ml)
Izimo Ezihlobene
I-Compound A Ehlobene (NO)	<0.10%
Inhlanganisela Ehlobene B (Ene-NO)	<0.10%
Inhlanganisela C Ehlobene (S,R)	<0.10%
Inhlanganisela Ehlobene D (R,S)	<0.50%
I-Palonosetron Enantiomer	<0.10%
Inhlanganisela Ehlobene E (3-Ene)	<0.50%
Ukungcola Okukodwa Okungacacisiwe	<0.10%
Izincibilikisi Ezisele
I-Ethanol	<3000ppm
I-Tetrahydrofuran	<5000ppm
I-DMF	<880ppm
I-Hexane evamile	<290ppm
I-Methyl Alcohol	<3000ppm
Isopropanol	<5000ppm
I-methylbenzene	<890ppm
Amanzi	<0.30%
Izinsalela ekushiseni	<0.20%
Ukulahlekelwa Ekumisweni	<1.00%
Izinsimbi Ezisindayo	<10ppm
Izinga Lokuhlola	I-United States Pharmacopoeia (USP);I-European Pharmacopoeia (EP)
Ukusetshenziswa	I-Palonosetron Hydrochloride API;5-HT3 Umphikisi;I-CINV

Iphakheji nesitoreji:

Iphakheji: Ibhodlela, I-Cardboard Drum, 25kg/Drum, noma ngokwezidingo zekhasimende.

Isitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni, umswakama kanye nezinambuzane.

Izinzuzo:

I-FAQ:

Isicelo:

I-Palonosetron Hydrochloride (CAS: 135729-62-3) iyisidakamizwa sokuvimbela isicanucanu nokuhlanza, okuwuhlobo olusha olukhetha kakhulu, oluhambisana kakhulu ne-5-HT3 receptor antagonist engavimba isikhungo sokuhlanza se-reflex neurons presynaptic 5-HT.Ukujabula kwesamukeli kuthinta ngokuqondile isimiso sezinzwa esimaphakathi ku-5-HT.Injabulo ye-impulse receptor ekhiqizwa indima ye-vagal afferent nerve ngemva kwendawo, ivimba iziphetho ze-vagus nerve emathunjini, ivimbela amasignali ku-5-HT.I-receptor trigger zone inganciphisa izehlakalo zokucanuzela kwenhliziyo nokuhlanza.Central Clinically yokwelashwa kwe-acute emetogenic chemotherapy ebangela ukubambezeleka kwesicanucanu nokuhlanza.Ngenxa yomphumela wayo ophezulu wokwelapha, umphumela omncane ongathandeki, impilo ende yesigamu (cishe 40 h), umthamo omncane, nokunye, kuye kwakhanga ukunaka okukhulu.

Nge-1,2,3,4-Tetrahydro-1-Naphthoic Acid njengento yokuqala, ukuhlukaniswa, ukukhishwa, ukunciphisa, i-cyclization, usawoti we-palonosetron hydrochloride granisetron.Ucwaningo lwezokwelapha lubonise ukuthi i-palonosetron ingasetshenziswa ngokuphepha ne-corticosteroids, ama-analgesics, ama-antiemetics, ama-antispasmodics kanye nezidakamizwa ezilwa ne-anticholinergic njengezinto zokuqala, ukuhlukaniswa, ukukhishwa, ukunciphisa, i-cyclization, usawoti we-palonosetron hydrochloride granisetron.