I-Polymyxin B Sulfate CAS 1405-20-5 Assay Microbiological ≥6500 IU/mg Factory
I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi oholayo nomphakeli we-Polymyxin B Sulfate (CAS: 1405-20-5) enekhwalithi ephezulu.Singahlinzeka nge-COA, ukulethwa komhlaba wonke, amanani amancane kanye nenqwaba etholakalayo.Uma unentshisekelo kuPolymyxin B Sulfate,Please contact: alvin@ruifuchem.com
| Igama Lekhemikhali | I-Polymyxin B sulfate |
| Omqondofana | I-Polymyxin B Sulfate Usawoti;I-Aerosporin;I-Mastimyxin;I-PXNS;PMB;I-Poly-RX |
| Isimo Sesitoko | Esitokweni, Amandla Okukhiqiza Amathani ayi-10 ngonyaka |
| Inombolo ye-CAS | 1405-20-5 |
| I-Molecular Formula | C55H96N16O13·2H2SO4 |
| Isisindo samangqamuzana | 1301.56 |
| I-Melting Point | 217.0~220.0℃(dec.) |
| Kuyazwela | I-Hygroscopic.Izwela Ukukhanya Nokushisa |
| Ukuncibilika kwamanzi | Incibilika Emanzini, 50 mg/mL.Incibilika Kancane ku-Ethanol |
| I-COA ne-MSDS | Iyatholakala |
| Isampula | Iyatholakala |
| Ibhrendi | I-Ruifu Chemical |
| Izinto | Imininingwane | Imiphumela |
| Ukubukeka | Okumhlophe noma Cishe Nge-Crystalline Powder | Kuyavumelana |
| Ukuhlonza A. Izikhathi zokugcinwa kweziqongo ezinkulu ezivela kusixazululo sesampula zihambisana nalezo zesixazululo esijwayelekile, njengoba kutholwe ekuhlolweni kokwakhiwa kwe-Polymyxins. | Kuyavumelana | |
| PH (2%) | 5.0~7.0 | 5.7 |
| PH (0.5%) | 5.0~7.5 | 5.5 |
| Umlotha one-sulphate | ≤0.75% |
|
| Ukuzungezisa Okuthile [α]20/D | -78.0°~-90.0°(C=2, H2O) (Calcd on Anh. Substance) | -85.0° |
| I-Sulfate | 15.5~17.5% | 16.65% |
| Ukulahlekelwa Ekumisweni | ≤6.00% | 3.0% |
| Izinsalela ekushiseni | ≤0.10% | 0.02% |
| Izinsimbi Ezisindayo | ≤20ppm | ≤20ppm |
| Phenylalanine | 9.0~12.0% | 9.8% |
| Isamba se-Viabel Aerobic Count | ≤10cfu/g | ≤10cfu/g |
| Izinto Ezihlobene, HPLC |
|
|
| Ukungcola Ngamunye | ≤3.0% | 2.723% |
| Ukungcola Okuphelele | ≤17.0% | 16.223% |
| I-Assay HPLC (ODB) | Isamba se-Polymyxins B1,B2,B3 kanye ne-B1-1: ≥80.0% | 86.6% |
| I-Polymyxin B3: ≤ 6.0% | 3.8% | |
| I-Polymyxin B1-1: ≤15.0% | 8.5% | |
| I-Assay, i-Microbiological (njengoba injalo) | ≥6500lU/mg | 8255IU/mg |
| Usayizi Wezinhlayiyana | ≥99.0% ≤30um ngevolumu | Kuyavumelana |
| ≥90.0% ≤25um ngevolumu | ||
| ≥75.0%≤20um ngevolumu | ||
| ≥35.0%≤10um ngevolumu | ||
| Isiphetho | Umkhiqizo uhambisana ne-USP42 |
|
Iphakheji:Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Ukuzwela ukukhanya.Gcina isiqukathi sivalwe ngokuqinile futhi usigcine endaweni epholile, eyomile (2~8℃) nengena umoya omuhle kude nezinto ezingahambelani.Vikela ekukhanyeni nakumswakama.Akuhambisani nama-oxidizing agents aqinile.
Ukuthumela:Zilethe emhlabeni wonke ngendiza, yi-FedEx/DHL Express.Nikeza ukulethwa okusheshayo nokuthembekile.
Indlela Yokuthenga?Sicela uxhumaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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IkhwalithiIsiqiniseko?Isistimu yokulawula ikhwalithi eqinile.Imishini yobuchwepheshe yokuhlaziya ifaka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, NOMA, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njll.
Amasampula?Imikhiqizo eminingi inikeza amasampula wamahhala wokuhlolwa kwekhwalithi, izindleko zokuthumela kufanele zikhokhelwe amakhasimende.
Ukuhlolwa Kwemboni?Wamukelekile ekucwaningweni kwemboni.Sicela wenze i-aphoyintimenti kusengaphambili.
I-MOQ?Ayikho i-MOQ.I-oda elincane liyamukeleka.
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Izimpawu Zengozi Xn - Ziyingozi
Amakhodi Engozi 22 - Ayingozi uma uwagwinyile
Incazelo Yezokuphepha S22 - Ungaluphefumuli uthuli.
I-S24/25 - Gwema ukuthintana nesikhumba namehlo.
Ama-ID e-UN 3249
I-WGK Germany 3
I-RTECS TR1150000
I-FLUKA BRAND F AMAKHODI 3-8-10
I-HS Code 2941909099
I-Hazard Class 6.1(b)
Ukupakisha Iqembu III
I-Polymyxin yiqembu lama-antibiotic e-polypeptide akhiqizwa yi-Bacillus polymyxa (bacilluspolymyxa).I-Polymyxin B no-E isetshenziselwa izinjongo zokwelapha, futhi ama-sulfate awo avame ukusetshenziswa.I-spectrum ye-antibacterial kanye nokusetshenziswa komtholampilo kwe-Polymyxin B Sulfate kuyafana naleyo ye-polymyxin E. Inemiphumela evimbelayo noma ye-bactericidal ku-bactericilli e-gram-negative, njenge-Escherichia coli, i-Pseudomonas aeruginosa, i-paracilli, i-Klebsiella pneumoniae, i-acidophilus, i-pertussis ne-Shigella.
I-Polymyxin Sulfate B ifana ne-polymyxin e, futhi inemiphumela evimbelayo noma ebulala amagciwane ku-bacterium-negative bacilli, njenge-e.coli, pseudomonas aeruginosa, paracilli, Klebsiella pneumoniae, acidophilus, bacilli pertussis kanye ne-dysentery bacilli.Isetshenziswa kakhulu enxebeni, emgudwini womchamo, iso, indlebe, uqhoqhoqho nezinye izingxenye zokutheleleka okubangelwa i-Pseudomonas aeruginosa nezinye i-Pseudomonas.Ingasetshenziselwa futhi i-sepsis ne-peritonitis.Futhi izifo ezinzima ezibangelwa ama-aminoglycosides, amagciwane amelana ne-cephalosporin esizukulwane sesithathu, i-Pseudomonas aeruginosa noma amanye amagciwane azwelayo, njenge-bacteremia, i-endocarditis, inyumoniya, ukutheleleka kwangemva kokushiswa, njll.
1. Ukuvuza komthambo: abadala kanye nezingane ezinomsebenzi wezinso ojwayelekile 1.5 ~ 2.5mg ngekhilogremu ngayinye yesisindo somzimba (ngokuvamile angabi ngaphezu kuka-2.5mg ngekhilogremu yesisindo somzimba) usuku olu-1, ihlukaniswe izikhathi ezingu-2, idonsa kanye njalo emahoreni ayi-12.Wonke ama-50mg alo mkhiqizo ahlanjululwa ngo-500ml we-5% ye-glucose solution bese econsa.Izinsana ezinomsebenzi wezinso ojwayelekile zingabekezelela i-4mg ngekhilogremu yesisindo somzimba usuku olu-1.2. Umjovo we-Intramuscular: abadala kanye nezingane: 2.5 ~ 3mg ngekhilogremu ngayinye yesisindo somzimba ngomhla ka-1, inikezwe ngamaqoqo, kanye njalo emahoreni angu-4 ~ 6.Izinsana zingafinyelela ku-4mg ngekhilogremu ngayinye yesisindo somzimba ngosuku futhi izingane ezisanda kuzalwa zingafinyelela ku-4.5mg ngekhilogremu ngayinye yesisindo somzimba.3. Umjovo we-intrathecal (we-Pseudomonas aeruginosa meningitis): 5mg ngemililitha yomuthi owuketshezi olungiselelwe ngomjovo we-sodium chloride.Abantu abadala kanye nezingane ezineminyaka engaphezu kwengu-2 ubudala, 5mg nsuku zonke, ngemva kwezinsuku ezingu-3-4 zokufaka isicelo, zishintsha zibe kanye ngosuku, okungenani amasonto ama-2, kuze kube yilapho isiko le-cerebrospinal fluid lingalungile, futhi okuqukethwe ushukela kuyinto evamile.Ezinganeni ezingaphansi kweminyaka engu-2 ubudala, sebenzisa i-2mg kanye ngosuku izinsuku ezingu-3-4 ezilandelanayo (noma i-2.5mg kanye njalo ngolunye usuku), bese usebenzisa i-2.5mg kanye ngosuku kuze kube yilapho ukuhlolwa sekujwayelekile.4. Ukugxila kwamaconsi iso yi-1 ~ 2.5mg nge-ml ngayinye.
Gwema ukuhlanganisa nezidakamizwa ezilimaza izinso, iziphumuli zemisipha yamathambo, ama-antibiotic e-aminoglycoside, ama-anesthetics anemiphumela ecacile yokuphumula kwemisipha (njenge-enflurane), njll., Futhi i-quinine, i-magnesium, njll. ayikwazi ukusetshenziswa nge-intravenously ngesikhathi esifanayo.I-Polymyxin B sulfate ihlanganiswa ne-sulfonamides, i-rifampicin, i-semi-synthetic penicillin, njll., ukuze kwelashwe izifo ezinzima zebhaktheriya ezingazweli emishanguzweni yegram-negative, futhi umphumela ungcono kunokusebenzisa okukodwa.
1, Abesifazane abakhulelwe nabancelisayo, izingane, kanye neziguli ezinokwehluleka okukhulu kwezinso zivame kakhulu.2. Lo mkhiqizo unobuthi kakhulu futhi unomphumela omubi wokwelapha ekuthelelekeni kwezicubu ezijulile.Akukona ukukhetha kokuqala kunoma yikuphi ukutheleleka.3. Ukujova ngomjovo kungase kubangele ukucindezeleka kokuphefumula, okuvame ukungasetshenziswa.Okungenani uhhafu womthamo wansuku zonke udinga ukuvuza ngomthambo, hhayi i-bolus esheshayo ngesikhathi esisodwa, ukuze ugweme ukuvimba okubanzi kwe-neuromuscular.4. Akufanele kuhlanganiswe nezinye izidakamizwa nge-nephrotoxicity noma i-neuromuscular blockade ukugwema izingozi.
Ucwaningo lwe-biochemical.I-Polymyxin B iyi-anti-gram-negative bacilli polypeptide antibiotic, engashintsha ukwakheka kwe-membrane ukuthi ivuze ama-molecule amancane futhi ivimbele ukukhula kwamagciwane e-gram-negative.Inomphumela we-bactericidal ku-Escherichia coli.Izingxenye ze-Lipid A eziboshelwe kuma-lipopolysaccharides ebhaktheriya.Izimbotshana ezincane zifakwa kulwelwesi lwamaseli esikhumba.Indlela yesenzo: ibopha futhi iphazamise ukungena kwe-cytoplasmic membrane.I-Antibacterial spectrum: Amagciwane ane-Gram-negative.
I-Polymyxin B, i-sulfate.
I-Polymyxin B Sulfate [1405-20-5].
» I-Polymyxin B Sulfate iwusawoti wesulfate wohlobo lwe-polymyxin, into ekhiqizwa ukukhula kwe-Bacillus polymyxa (Prazmowski) Migula (Fam. Bacillaceae), noma ingxube kasawoti onjalo amabili noma ngaphezulu.Inamandla angekho ngaphansi kwamayunithi angama-6000 e-Polymyxin B nge-mg, abalwe ngokomisiwe.
Ukupakisha nokugcina-Londoloza ezitsheni eziqinile, ezimelana nokukhanya.
Ukulebula-Lapho kupakishwe ukuze kuhlanganiswe incwadi kadokotela, ilebula isho inani lamayunithi e-Polymyxin B esitsheni kanye ne-milligram ngayinye, ukuthi ayihloselwe ukusetshenziswa kokukhiqiza, ukuthi ayinyumba, nokuthi amandla ayo angeke aqinisekiswe isikhathi eside kune-60. izinsuku ngemuva kokuvulwa.Lapho ihloselwe ukusetshenziswa ekulungiseni amafomu omthamo omjovo noma amanye amagciwane, ilebula ithi ayinyumba noma kufanele iqhubeke nokucutshungulwa ngesikhathi sokulungiswa kwamafomu omjovo noma amanye amagciwane.
Amazinga ereferensi we-USP <11>-
I-USP Polymyxin B Sulfate RS
Ukuhlonza-
A: Ukuhlolwa kwe-Liquid Chromatographic Identification-
Isigaba seselula-Lungiselela ingxube ye-0.1 M tribasic sodium phosphate ne-acetonitrile (77:23), futhi ulungise ne-phosphoric acid ibe i-pH engu-3.0.Yenza izinguquko uma kudingeka (bona Ukufaneleka Kwesistimu ngaphansi kwe-Chromatography <621>.
Isixazululo esijwayelekile-Lungiselela isixazululo se-USP Polymyxin B Sulfate RS esigabeni Seselula esinokugxila okungaba ngu-3.5 mg ngemL ngayinye.Vikela lesi sixazululo ekukhanyeni.
Isixazululo sokuhlola-Lungiselela isixazululo se-Polymyxin B Sulfate esigabeni se-Mobile ene-concentration cishe engu-3.5 mg nge-mL ngayinye.Vikela lesi sixazululo ekukhanyeni.
Isistimu ye-Chromatographic (bona i-Chromatography <621>)-I-chromatograph ewuketshezi ifakwe umtshina ongu-212-nm kanye nekholomu engu-4.6-mm × 25-cm equkethe 5-µm ukupakisha L1.Izinga lokugeleza licishe libe ngu-1 mL ngomzuzu.
Inqubo-Ngokuhlukene jova amavolumu alinganayo (cishe u-10 µL) wesisombululo Esijwayelekile kanye nesixazululo sokuhlola ku-chromatograph, futhi urekhode ama-chromatogram.Ichromatogram etholwe esixazululweni sokuhlola ihambisana ngokwemfanelo naleyo etholwe kusixazululo Esijwayelekile, ebonisa ukuphakama okukhulu okuhambisana ne-polymyxin B1 kanye neziqongo ngezikhathi zokugcinwa okuhlobene ezingaba ngu-0.5 (polymyxin B2) kanye no-0.6 (polymyxin B3).
B: Chaza u-2 mg ku-5 mL wamanzi, engeza u-5 mL ka-2.5 N sodium hydroxide, hlanganisa, bese wengeza amaconsi ama-5 esixazululo se-cupric sulfate (1 ku-100), unyakazise ngemva kokwengezwa kweconsi ngalinye: kukhiqizwa umbala obomvana obomvana. .
C: Isixazululo (1 ku-20) sihlangabezana nezidingo zokuhlolwa kwe-Sulfate <191>.
i-pH <791>: phakathi kuka-5.0 no-7.5, esixazululweni esiqukethe u-5 mg nge-mL ngayinye.
Ukulahlekelwa lapho ukoma <731>-Yomisa cishe u-100 mg, ukalwe ngokunembile, ebhodleleni eline-capillary-stoppered ku-vacuum engu-60℃ amahora angu-3: alahlekelwa ngaphezu kuka-7.0% wesisindo sawo.
Okuqukethwe kwe-phenylalanine-Dlulisa cishe u-0.375 g we-Polymyxin B Sulfate, ikalwe ngokunembile, iye ku-100-mL ye-volumetric flask, ncibilika futhi uhlambuluke nge-0.1 N hydrochloric acid ukuya kuvolumu, bese uxuba.Linganisa ukumuncwa kwalesi sixazululo ku-maxima cishe ku-264 nm (A264), 258 nm (A258), no-252 nm (A252), kanye nokudonsa ku-280 nm (A280) no-300 nm (A300).Bala amaphesenti e-phenylalanine engxenyeni ye-Polymyxin B Sulfate ethathwe ifomula:
(9.4787/W)(A258 – 0.5A252 + 0.5A264 – 1.84A280 + 0.8A300)
lapho u-W eyisisindo, ngo-g, sePolymyxin B Sulfate ethathiwe: iqukethe phakathi kuka-9% no-12% we-phenylalanine, ebalwa ngesisekelo esomisiwe.
Ezinye izimfuneko- Uma ngokuhlanganiswa kwencwadi kadokotela, ihlangabezana nezimfuneko Zensalela lapho ivutha ngaphansi kwe-Polymyxin B Yomjovo.Lapho ilebula ithi i-Polymyxin B Sulfate iyinyumba, ihlangabezana nezimfuneko Zokuhlolwa Kokuqina Kwezinzalo <71> futhi, lapho kuhloselwe amafomu omthamo omjovo, ye-Pyrogen ngaphansi kwe-Polymyxin B Yomjovo.Lapho ilebula ithi i-Polymyxin B Sulfate kufanele iqhubeke nokucutshungulwa ngesikhathi sokulungiswa kwamafomu omthamo omjovo, ihlangabezana nezimfuneko zePyrogen ngaphansi kwePolymyxin B Yomjovo.
I-Assay-Qhubeka nge-Polymyxin B Sulfate njengoba kuqondiswe ngaphansi kwe-Antibiotics-Microbial Assays <81>.
