I-Pregabalin CAS 148553-50-8 Purity >99.0% (HPLC) Antiepileptic API
Umkhiqizi onoPurity Okuphezulu kanye Nokukhiqiza Kwezentengiso
Igama Lekhemikhali: PregabalinI-CAS: 148553-50-8
I-Pregabalin iyisidakamizwa sesizukulwane sesibili se-antiepileptic (AED)
Igama Lekhemikhali | I-Pregabalin |
Omqondofana | (S) -3-(Aminomethyl)-5-Methylhexanoic Acid;PD-144723;PD144723;I-CI 1008;I-CI-1008;I-Lyrica |
Inombolo ye-CAS | 148553-50-8 |
Inombolo yeCAT | I-RF-API57 |
Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani |
I-Molecular Formula | I-C8H17NO2 |
Isisindo samangqamuzana | 159.23 |
I-Melting Point | 194.0 ~ 196.0℃ |
Ukuncibilika Emanzini | Ayincibiliki Emanzini |
Ukuncibilika | Incibilika Kancane ku-Ethanol |
Isimo Sokuthumela | Ngaphansi Kwezinga Lokushisa Le-Ambient |
Ibhrendi | I-Ruifu Chemical |
Into | Imininingwane |
Ukubukeka | I-Crystalline Powder emhlophe ukuya kokumhlophe |
Ukuhlonza | I-IR: Ifana Nereferensi Into |
Ukuzungezisa okuqondile | +10.0°~+13.0° (C=1, Amanzi) |
Ukulahlekelwa Ekumisweni | <0.50% |
Umlotha one-sulphate | <0.10% |
Izinto Ezihlobene | Ukungcola A <0.15% |
Ukungcola Okungacacisiwe Okuphumayo Ngaphambi Kwe-Pregabalin (ukuhlolwa A) <0.10% | |
Ukungcola Okungacacisiwe Okuphuma Ngemva Kwe-Pregabalin (ukuhlolwa B ) <0.10% | |
Isamba sokuhlolwa A no-B <0.50% | |
Ubumsulwa Nge-HPLC R-Isomer | <0.15% |
Izinsimbi Ezisindayo (njenge-Pb) | <10ppm |
Ama-Chlorides (Cl) | <0.05% |
Izincibilikisi Ezisele | |
Isopropyl Utshwala | <5000ppm |
I-Ethyl Acetate | <5000ppm |
I-Tetrahydrofuran | <250ppm |
I-Isopropyl Ether | <500ppm |
I-Ethanol | <1000ppm |
Ukuhlanzeka / Indlela Yokuhlaziya | >99.0% (HPLC ngokomisiwe) |
Izinga Lokuhlola | I-Enterprise Standard |
Ukusetshenziswa | I-Antiepileptic Drug API |
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwemfuneko yekhasimende
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni nakumswakama
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I-Pregabalin iyisidakamizwa sesizukulwane sesibili se-antiepileptic (AED) eyaziwa ngegama lobunikazi lobunikazi be-Lyrica (Pfizer, Tadworth) e-UK nase-USA, enesakhiwo se-γ-amino butyric acid esakhiweni sawo samangqamuzana, anemiphumela yokulwa nokuquleka, futhi ithuthukiswe ngempumelelo yinkampani i-Pfizer yokwelapha ubuhlungu be-neuropathic be-peripheral, noma ukwelashwa kwe-adjuvant yokuquleka okuyingxenye.I-Pregabalin iyisidakamizwa se-Anticonvulsant ne-antiepileptic esetshenziselwa ukwelapha isithuthwane, ubuhlungu be-neuropathic, i-fibromyalgia, kanye nesifo sokukhathazeka okujwayelekile.Ukusetshenziswa kwaso ekwelapheni isithuthwane kunjengokwelashwa okungeziwe kokuquleka ingxenye noma ngaphandle kokujwayelekile kwesibili kubantu abadala.NgoZibandlela wezi-2008, i-US Food and Drug Administration (FDA) yagunyaza i-pregabalin (igama lokuhweba elithi "Lyrica") ukuze zelashwe ubuhlungu be-diabetic peripheral neuropathic (DPN) kanye ne-postherpetic neuralgia (PHN) okubili izinhlungu ezivame kakhulu ze-neuropathic.I-Pregabalin inenkomba egunyaziwe futhi isetshenziswa kabanzi ekwelapheni ukuphazamiseka kokukhathazeka okujwayelekile.Izivivinyo eziningana ezingahleliwe, ezingaboni kabili, ezilawulwa yi-placebo zathola ukuthi i-pregabalin iyindlela yokwelapha ephumelelayo yeziguli ezinokuphazamiseka kokukhathazeka okujwayelekile kanye nokukhathazeka komphakathi.I-Dose titration Ukwelashwa kwe-Epilepsy-adjunctive: 25 mg bd izinsuku ezingu-7, kufanele kukhuliswe ngo-50 mg njalo ezinsukwini ezingu-7;ukugcinwa evamile 300 mg nsuku zonke, ihlukaniswe 2 noma 3 imithamo (max. 600 mg nsuku zonke, ihlukaniswe 2 noma 3 imithamo).I-Generalized Anxiety Disorder: I-150 mg nsuku zonke, ihlukaniswe ngemithamo emi-2 noma engu-3, izinsuku ezingu-7, ukuze inyuswe ngo-150 mg njalo ezinsukwini ezingu-7 (ubukhulu be-600 mg nsuku zonke, ihlukaniswe ngemithamo emi-2 noma emi-3).Uma umisa i-pregabalin, kutuswa ukuthi uthinte okungenani iviki elingu-1 ukuze ugweme ukuhoxiswa kungazelelwe.Izexwayiso Iziguli ezinezimo ezingase zibangele i-encephalopathy.Iziguli ezinokwehluleka kwenhliziyo okuminyanisa okukhulu.
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