I-Pregabalin CAS 148553-50-8 Purity >99.0% (HPLC) Antiepileptic API

I-Pregabalin iyisidakamizwa sesizukulwane sesibili se-antiepileptic (AED) eyaziwa ngegama lobunikazi lobunikazi be-Lyrica (Pfizer, Tadworth) e-UK nase-USA, enesakhiwo se-γ-amino butyric acid esakhiweni sawo samangqamuzana, anemiphumela yokulwa nokuquleka, futhi ithuthukiswe ngempumelelo yinkampani i-Pfizer yokwelapha ubuhlungu be-neuropathic be-peripheral, noma ukwelashwa kwe-adjuvant yokuquleka okuyingxenye.I-Pregabalin iyisidakamizwa se-Anticonvulsant ne-antiepileptic esetshenziselwa ukwelapha isithuthwane, ubuhlungu be-neuropathic, i-fibromyalgia, kanye nesifo sokukhathazeka okujwayelekile.Ukusetshenziswa kwaso ekwelapheni isithuthwane kunjengokwelashwa okungeziwe kokuquleka ingxenye noma ngaphandle kokujwayelekile kwesibili kubantu abadala.NgoZibandlela wezi-2008, i-US Food and Drug Administration (FDA) yagunyaza i-pregabalin (igama lokuhweba elithi "Lyrica") ukuze zelashwe ubuhlungu be-diabetic peripheral neuropathic (DPN) kanye ne-postherpetic neuralgia (PHN) okubili izinhlungu ezivame kakhulu ze-neuropathic.I-Pregabalin inenkomba egunyaziwe futhi isetshenziswa kabanzi ekwelapheni ukuphazamiseka kokukhathazeka okujwayelekile.Izivivinyo eziningana ezingahleliwe, ezingaboni kabili, ezilawulwa yi-placebo zathola ukuthi i-pregabalin iyindlela yokwelapha ephumelelayo yeziguli ezinokuphazamiseka kokukhathazeka okujwayelekile kanye nokukhathazeka komphakathi.I-Dose titration Ukwelashwa kwe-Epilepsy-adjunctive: 25 mg bd izinsuku ezingu-7, kufanele kukhuliswe ngo-50 mg njalo ezinsukwini ezingu-7;ukugcinwa evamile 300 mg nsuku zonke, ihlukaniswe 2 noma 3 imithamo (max. 600 mg nsuku zonke, ihlukaniswe 2 noma 3 imithamo).I-Generalized Anxiety Disorder: I-150 mg nsuku zonke, ihlukaniswe ngemithamo emi-2 noma engu-3, ​​izinsuku ezingu-7, ukuze inyuswe ngo-150 mg njalo ezinsukwini ezingu-7 (ubukhulu be-600 mg nsuku zonke, ihlukaniswe ngemithamo emi-2 noma emi-3).Uma umisa i-pregabalin, kutuswa ukuthi uthinte okungenani iviki elingu-1 ukuze ugweme ukuhoxiswa kungazelelwe.Izexwayiso Iziguli ezinezimo ezingase zibangele i-encephalopathy.Iziguli ezinokwehluleka kwenhliziyo okuminyanisa okukhulu.