I-Pyridine-3-Sulfonyl Chloride CAS 16133-25-8 Purity ≥98.5% (GC) I-Vonoprazan Fumarat Intermediate Factory
Ukunikezela nge-Vonoprazan Fumarate kanye Nezimaphakathi Ezihlobene
5-(2-Fluorophenyl)pyrrole-3-Carboxaldehyde CAS 881674-56-2
I-Pyridine-3-Sulfonyl Chloride CAS 16133-25-8
I-Vonoprazan Fumarate (TAK-438) CAS 1260141-27-2 881681-01-2
Igama Lekhemikhali | I-Pyridine-3-Sulfonyl Chloride |
Omqondofana | 3-Pyridinesulfonyl Chloride;3-Pyridylsulfonyl Chloride;m-Pyridinesulfonyl Chloride;I-Piperidine-3-Sulfonylchloride |
Inombolo ye-CAS | 16133-25-8 |
Inombolo yeCAT | I-RF-PI540 |
Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani |
I-Molecular Formula | I-C5H4ClNO2S |
Isisindo samangqamuzana | 177.61 |
Ibhrendi | I-Ruifu Chemical |
Into | Imininingwane |
Ukubukeka | Uketshezi Oluphuzi Olungenambala noma Oluphuzi |
Ukuhlanzeka / Indlela Yokuhlaziya | ≥98.5% (GC) |
Iphuzu elibilayo | 110.0 ~ 112.0℃/2mm Hg |
Ukungcola Okukodwa | ≤0.50% |
Ukungcola Okuphelele | ≤1.5% |
Izinga Lokuhlola | I-Enterprise Standard |
Ukusetshenziswa | I-Intermediate ye-Vonoprazan Fumarate (CAS: 1260141-27-2) |
Iphakheji: Ibhodlela, 25kg/Umgqomo, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni nakumswakama.
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I-Pyridine-3-Sulfonyl Chloride (i-CAS: 16133-25-8) iphakathi kwe-Vonoprazan Fumarate (CAS: 1260141-27-2).I-Vonoprazan Fumarate, eyatholwa futhi yathuthukiswa ngu-Takeda no-Otsuka, yagunyazwa yi-PMDA yaseJapane ngoDisemba 2014, futhi ikhonjiswe ekwelapheni isilonda sesisu, isilonda se-duodenal kanye ne-reflux esophagitis.I-Vonoprazan fumarate inomshini wokusebenza wenoveli obizwa ngokuthi i-potassium-competitive acid blockers, evimbela ngokuncintisana ukuboshwa kwama-ion e-potassium ku-H+, K+-ATPase (eyaziwa nangokuthi iphampu ye-proton) esinyathelweni sokugcina sokuphuma kwe-asidi esiswini kumaseli e-gastric parietal.I-Vonoprazan ayivimbeli umsebenzi we-Na+, K+-ATPase ngisho nasekugxiliseni izikhathi ezingu-500 ngaphezu kwamanani e-IC50 uma kuqhathaniswa nomsebenzi wesisu we-H+, K+-ATPase.Ngaphezu kwalokho, umuthi awuthintwa yi-gastric secretory state, ngokungafani nama-PPI.