(R)-(+)-2-Methyl-CBS-oxazaborolidine;(R)-Me-CBS Catalyst CAS 112022-83-0 Optical Purity ≥98.0%

Ukuhlinzekwa komkhiqizi;Ikhwalithi ephezulu kanye Nentengo Encintisanayo

I-CBS Catalysts
(S)-(-)-2-Methyl-CBS-oxazaborolidine;(S)-Me-CBS Catalyst (ca. 1mol/L ku-Toluene);I-CAS: 112022-81-8
(R)-(+)-2-Methyl-CBS-oxazaborolidine;(R)-Me-CBS Catalyst (ca. 1mol/L ku-Toluene);I-CAS: 112022-83-0

I-CBS Catalyst
I-CBS catalyst noma i-Corey–Bakshi–Shibata catalyst i-asymmetric catalyst etholakala ku-proline.Ithola ukusetshenziswa okuningi ekuphenduleni kwezinto eziphilayo njengokunciphisa kwe-CBS, ukusabela kwe-Diels-Alder kanye (3+2) nama-cycloadditions.I-Proline, inhlanganisela ye-chiral eyenzeka ngokwemvelo, itholakala kalula futhi ngeshibhile.Idlulisela i-stereocenter yayo ku-catalyst yona ekwazi ukushayela ukusabela kwe-organic ngokukhetha eyodwa kwezimbili zama-enantiomers ezingaba khona.Lokhu kukhetha kungenxa yokuqina kwesimo soshintsho esithuthukela i-enantiomer eyodwa kodwa hhayi kwenye.

I-CBS Catalysts Yokuncishiswa kwe-Asymmetric kanye ne-Asymmetric Synthesis
I-CBS (i-Corey-Bakshi-Shibata) i-oxazaborolidine catalyst isetshenziswe ekwehliseni i-asymmetric yama-prochiral ketones.Ezinye izinhlelo zokusebenza zihlanganisa ukuhlanganiswa kwe-enantioselective kwe-α-hydroxy acid, i-α-amino acid, i-C2-symmetrical ferrocenyl diols, kanye ne-propargyl alcohols.

(R)-(+)-2-Methyl-CBS-oxazaborolidine (ca. 1mol/L ku-Toluene) I-CAS: 112022-83-0 ingasetshenziswa njenge-catalyst ekunciphiseni kwe-asymmetric borane ye-perfluoroalkyl ketones.Ezinye izinhlelo zokusebenza zihlanganisa ukuhlanganiswa kwe-enantioselective kwama-α-hydroxy acid, i-α-amino acid, i-C2 symmetrical ferrocenyl diols, kanye ne-propargyl alcohols.Iphinde isetshenziswe ekunciphiseni i-desymmetrizing okuholela ku-(S) -4-hydroxycyclohexenone.Iwusizo ekukhiqizeni i-stereospecific motifs efana ne-α-hydroxy acids, i-α-amino acids, i-symmetrical ferrocenyl diols kanye ne-propargyl alcohols.

(R)-(+)-2-Methyl-CBS-oxazaborolidine (ca. 1mol/L ku-Toluene) I-CAS: 112022-83-0 i-organoboron catalyst esetshenziswa ku-organic synthesis.Le catalyst, eyakhiwe ngu-Itsuno no-Elias James Corey, ikhiqizwa ngokufudumeza (R) -(+) -2-(diphenylhydroxymethyl) pyrrolidine kanye ne-trimethylboroxine noma i-methylboronic acid.Kuyithuluzi elihle kakhulu lokuhlanganiswa kotshwala ngenani eliphakeme le-enantiomeric.Ngokuvamile, i-2-10 mol% yale catalyst isetshenziswa kanye ne-borane-tetrahydrofuran (THF), i-borane-dimethylsulfide, i-borane-N, i-N-diethylaniline, noma i-diborane njengomthombo we-borane.Ukuncishiswa kwe-Enantioselective kusetshenziswa i-chiral oxazaborolidine catalysts isetshenziswe ekuhlanganiseni kwezidakamizwa zentengiso ezifana ne-ezetimibe ne-aprepitant.