English
(R)-(-)-3-Pyrrolidinol Hydrochloride CAS 104706-47-0 Purity ≥99.7% (GC) Chiral Purity ≥99.7% Panipenem ne-Darifenacin hydrobromide Isithombe Esimaphakathi Esifakiwe
  • (R)-(-)-3-Pyrrolidinol Hydrochloride CAS 104706-47-0 Purity ≥99.7% (GC) Chiral Purity ≥99.7% Panipenem ne-Darifenacin hydrobromide Intermediate

(R)-(-)-3-Pyrrolidinol Hydrochloride CAS 104706-47-0 Purity ≥99.7% (GC) Chiral Purity ≥99.7% Panipenem ne-Darifenacin hydrobromide Intermediate

Incazelo emfushane:

Igama Lekhemikhali: (R)-(-)-3-Pyrrolidinol Hydrochloride

I-CAS: 104706-47-0

Ukubukeka: Okumhlophe Okumhlophe kuya Kuphuphu Obucwebe Olunsundu Ophaphathekile

Ubumsulwa: ≥ 99.7%(GC)

Ukuhlanzeka kweChiral: ≥ 99.7% ee

I-Intermediate ye-Panipenem (CAS 87726-17-8) ne-Darifenacin hydrobromide (CAS 133099-07-7)


Imininingwane Yomkhiqizo

Imikhiqizo Ehlobene

Omaka bomkhiqizo

Incazelo:

Ukuhlinzekwa komkhiqizi;Ukuhlanzeka Okuphezulu Nentengo Encintisanayo
Shanghai Ruifu Chemical Co., Ltd. Commercial Supply Chiral Compounds:
(R)-(-)-3-Pyrrolidinol Hydrochloride CAS: 104706-47-0
(S)-3-Hydroxypyrrolidine hydrochloride CAS: 122536-94-1
I-Intermediate ye-Panipenem (CAS 87726-17-8) ne-Darifenacin hydrobromide (CAS 133099-07-7)

Chemical Properties:

Igama Lekhemikhali (R)-(-)-3-Pyrrolidinol Hydrochloride
Omqondofana (R)-(-)-3-Hydroxypyrrolidine Hydrochloride;(R)-(-)-3-Hydroxypyrrolidine-HCl
Inombolo ye-CAS 104706-47-0
Inombolo yeCAT I-RF-CC102
Ukuhlanzeka / Indlela Yokuhlaziya ≥98.0% (GC)
Isimo Sesitoko Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani
I-Molecular Formula I-C4H10ClNO
Isisindo samangqamuzana 123.58
I-Melting Point 107.0 ~ 111.0 °C
Ukuncibilika Emanzini Cishe Ukungafihli
Ibhrendi I-Ruifu Chemical

Imininingwane:

Into Imininingwane
Ukubukeka I-Off-White ukuya ku-Pale Brown Crystalline Powder
Ukuhlanzeka / Indlela Yokuhlaziya ≥99.7% (GC)
I-Chiral Purity ≥99.7% ee
Izinsalela ekushiseni ≤0.50%
Ukuzungezisa Okuqondile [α]D20 -6.5°~ -8.5° (C=3.5 CH3OH)
Noma yikuphi Ukungcola Komuntu Ngamunye ≤0.20%
Ukungcola okuphelele ≤0.30%
Izinga Lokuhlola I-Enterprise Standard
Ukusetshenziswa Abalamuli Bezemithi;I-Chiral Compounds

Indlela Yokuhlaziya
Isisetshenziswa: Insimbi ye-GC (Shimadzu GC-2010)
Ikholomu: DB-17 Agilent 30mX0.53mmX1.0μm
Ukushisa kwe-oven yokuqala: 80 ℃
Isikhathi sokuqala 2.0min
Linganisa 15℃/min
Izinga lokushisa likahhavini lokugcina: 250 ℃
Isikhathi sokugcina 20min
I-Carrier gas Nitrogen
Imodi Ukugeleza Okuqhubekayo
Ukugeleza 5.0mL/min
Isilinganiso sokuhlukaniswa 10:1
Izinga lokushisa lomjovo: 250 ℃
Ukushisa komtshina: 300 ℃
Ivolumu yomjovo 1.0μL

Izinyathelo okufanele zithathwe ngaphambi kokuhlaziywa:
1. Ikholomu yesimo ku-240℃ ubuncane bemizuzu engama-30.
2. Geza isipetu bese uhlanza ijector liner ngendlela efanele ukuze ususe ukungcola kokuhlaziya kwangaphambili.
3. Geza, womise futhi ugcwalise i-diluent ezitsheni zokugeza isirinji.
Ukulungiselela i-Diluent:
Lungiselela isixazululo esingu-2% w/v sodium hydroxide emanzini.
Ukulungiselela okujwayelekile:
Kala cishe u-100mg we-(R)-3-hydroxyprrolidine hydrochloride ejwayelekile ebhodleleni, engeza u-1mL we-diluent bese uncibilikisa.
Ukulungiselela ukuhlolwa:
Kala cishe u-100mg wesampula yokuhlola ebhodleleni, engeza u-1mL we-diluent bese uncibilikisa.Lungiselela ngempinda.
Inqubo:
Jova kungenalutho (i-diluent), ukulungiswa okujwayelekile kanye nokulungiselela ukuhlolwa usebenzisa izimo ze-GC ezingaphezulu.Ziba iziqongo ngenxa yokungenalutho.Isikhathi sokugcina sokuphakama ngenxa ye-(R) -3-hydroxyprrolidine singaba ngu-5.0min.
Qaphela:
Bika umphumela njengesilinganiso

Iphakheji nesitoreji:

Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, isigubhu seCardboard, 25kg/Drum, noma ngokwezidingo zekhasimende.

Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni, umswakama kanye nezinambuzane.

Izinzuzo:

Amandla Anele: Izinsiza ezanele kanye nochwepheshe

Isevisi Yobuchwepheshe: Isevisi yokuthenga yokuma eyodwa

Iphakheji le-OEM: Iphakheji yangokwezifiso kanye nelebula iyatholakala

Ukulethwa Okusheshayo: Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe

Impahla Ezinzile: Gcina isitoko esinengqondo

Ukusekelwa Kwezobuchwepheshe: Isixazululo sezobuchwepheshe siyatholakala

Isevisi Yokuhlanganisa Ngokwezifiso: Isukela kumagremu kuye kumakhilo

Ikhwalithi Ephezulu: Kusungulwe uhlelo oluphelele lokuqinisekisa ikhwalithi

I-FAQ:

121

Isicelo:

I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi oholayo nomphakeli we-(R)-(-)-3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) enekhwalithi ephezulu, esetshenziswa kabanzi ku-organic synthesis, ukuhlanganiswa kwemithi ephakathi kwemithi. kanye ne-Active Pharmaceutical Ingredient (API) synthesis.

(R)-(-)-3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) iphakathi ngokuvamile ekuhlanganiseni kwe-Panipenem (CAS 87726-17-8) kanye ne-Darifenacin hydrobromide (CAS 133099-07-7).

(R)-(-)-3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) i-chiral hydroxy derivative ye-pyrrlodine esetshenziselwa ukulungiswa kwe-chiral niologically active compounds njenge-muscarinic receptor antagonists kanye nama-antimicrobial agents.

Umzila Wokwenziwa kwe-(R) -3-Hydroxypyrrolidine hydrochloride
(R) -4-chloro-3-hydroxybutanitrile yasabela nge-trimethyl chlorosilane kusincibilikisi se-dichloromethane ukuze kutholwe (R) -4-chloro-3-trimethylsiloxy butanitrile.(R) -4-chloro-3-trimethylsiloxyebutylamine wabe ese-hydrogenated ku-Pd / C catalyst. (R) -3-trimethylsiloxyepyrrolidine itholwe ngokwelashwa kokuvala indandatho ye-sodium hydroxide.Ekugcineni, umkhiqizo (R) -3-hydroxypyrrolidine hydrochloride watholwa ngokwelashwa okugxilile kwe-hydrochloric acid futhi iqembu lokuvikela le-trimethylsilyl lasuswa.

Bhala umyalezo wakho lapha futhi usithumelele wona