(R)-(-)-3-Quinuclidinol CAS 25333-42-0 Ubumsulwa ≥99.0% Chiral Purity ≥99.0%
Igama Lekhemikhali | (R)-(-)-3-Quinuclidinol |
Omqondofana | (R)-3-Quinuclinol |
Inombolo ye-CAS | 25333-42-0 |
Inombolo yeCAT | I-RF-CC117 |
Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani |
I-Molecular Formula | C7H13NO |
Isisindo samangqamuzana | 127.18 |
Ibhrendi | I-Ruifu Chemical |
Into | Imininingwane |
Ukubukeka | Impushana Emhlophe noma Engamhlophe |
I-Identification RT (by GC) | Vumelana Nezinga Lereferensi |
I-Melting Point | 212.0~224.0℃ |
Ukuzungezisa Okuqondile [α]D20 | -40.0°~ -48.0° |
Umswakama (KF) | ≤0.50% |
Izinsalela ekushiseni | ≤0.50% |
Ubumsulwa | ≥99.0% |
Ukungcola Okuphelele | ≤1.00% |
I-Chiral Purity | ≥99.0% |
I-Enantiomer | ≤1.00% |
Isivivinyo | 98.0%~101.0% (Kusisekelo Esingenamanzi) |
Izinga Lokuhlola | I-Enterprise Standard |
Ukusetshenziswa | I-Chiral Compounds;Pharmaceutical Intermediates |
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwemfuneko yekhasimende
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni nakumswakama
I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi oholayo kanye nabaphakeli be-(R)-(-)-3-Quinuclidinol (CAS: 25333-42-0) enekhwalithi ephezulu, esetshenziswa kabanzi ku-organic synthesis, synthesis of pharmaceutical intermediates and I-Active Pharmaceutical Ingredient (API) synthesis.(R)-(-)-3-Quinuclidinol ingasetshenziswa njengendawo emaphakathi ekuhlanganisweni kwe-API (CAS: 242478-38-2).(CAS: 242478-38-2) umuthi we-antimuscarinic osetshenziselwa ukwelapha esinyeni esisebenza ngokweqile esibangela izimpawu zokuvama, ukuphuthuma, noma ukungakwazi ukuzibamba.(I-CAS: 242478-38-2) i-M3 muscarinic receptor antagonist eyakhiwe futhi yethulwa ukwelashwa kwesinye esisebenza ngokweqile (i-pollakiuria) eYurophu.I-M3 receptors iye yathinteka ekufinyezweni kwemisipha ebushelelezi ekhishwe yi-neurally yesinye, futhi ama-M2 receptors nawo asolwa ngokudlala indima ngenxa yokubusa kwawo ku-detrusor muscle.Ukuhlanganiswa kwe-solifenacin kuhilela ukulungiswa kwe-racemic 1-Phenyl-1,2,3,4-Tetrahydroisoquinoline nge-cyclization ye-N-(2-Phenylethyl)benzamide, kanye nokusabela okulandelayo nge-ethyl chloroformate kanye ne-transesterification nge-(R)-3-Quinuclidinol. .I-Chiral chromatography inikeza ukuhlukaniswa kwe-diastereomer oyifunayo.Kungenjalo, i-1-Phenyl-1,2,3,4-Tetrahydroisoquinoline ingase ibekwe ngaphansi kokuxazululwa kwe-optical (+) -Tartaric Acid ngaphambi kokwelashwa nge-ethyl chloroformate kanye ne-transesterification elandelayo.