I-Ramelteon Intermediate 12 CAS 1053239-39-6 Ubumsulwa >98.0% (HPLC)

Incazelo emfushane:

Igama Lekhemikhali: 2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl)ethanamine Hydrochloride

Synonyms: Ramelteon Intermediate 12

I-CAS: 1053239-39-6

Ubumsulwa: >98.0% (HPLC)

Ukubukeka: Okumhlophe kuya Kokumhlophe Okuqinile Okuqinile

I-Intermediate of Ramelteon (CAS: 196597-26-9)

Thintana: UDkt. Alvin Huang

Iselula/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Imikhiqizo Ehlobene

Omaka bomkhiqizo

Incazelo:

Umkhiqizi Oholayo Nomhlinzeki, Abaphakathi kwe-Ramelteon
I-Ramelteon (TAK-375) CAS 196597-26-9
2,3-Dihydrobenzofuran CAS 496-16-2
1,2,6,7-Tetrahydro-8H-Indeno[5,4-b]furan-8-one CAS 196597-78-1
I-Ramelteon Acrylonitrile CAS 196597-79-2
I-Despropionyl Ramelteon Hydrochloride CAS 196597-80-5
2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl)ethanamine Hydrochloride CAS 1053239-39-6
Please contact: alvin@ruifuchem.com

Chemical Properties:

Igama Lekhemikhali	2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl)ethanamine Hydrochloride
Omqondofana	Ramelteon Intermediate 12;I-Ramelteon Stage-2 Ukungcola;1,6,7,8-Tetrahydro-2H-Indeno[5,4-B]Furan-8-Ethanamine Hydrochloride
Inombolo ye-CAS	1053239-39-6
Inombolo yeCAT	I-RF2887
Isimo Sesitoko	Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani
I-Molecular Formula	I-C13H18ClNO
Isisindo samangqamuzana	239.74
I-Melting Point	165.0 ~ 167.0℃
Ukuminyana	1.058±0.06 g/cm3
Ibhrendi	I-Ruifu Chemical

Imininingwane:

Into	Imininingwane
Ukubukeka	Impushana Eqinile Emhlophe ukuya Kokumhlophe
Ukuhlanzeka / Indlela Yokuhlaziya	>98.0% (HPLC)
Ukulahlekelwa Ekumisweni	<1.00%
Ukungcola Okukodwa	<1.00%
Ukungcola Okuphelele	<2.00%
1 H NMR Spectrum	Ihambisana Nesakhiwo
Izinga Lokuhlola	I-Enterprise Standard
Ukusetshenziswa	I-Intermediate of Ramelteon (CAS: 196597-26-9)

Iphakheji nesitoreji:

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Impahla Ezinzile: Gcina isitoko esinengqondo

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Ikhwalithi Ephezulu: Kusungulwe uhlelo oluphelele lokuqinisekisa ikhwalithi

I-FAQ:

Indlela Yokuthenga?Sicela uxhumaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

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IkhwalithiIsiqiniseko?Isistimu yokulawula ikhwalithi eqinile.Imishini yobuchwepheshe yokuhlaziya ifaka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, NOMA, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njll.

Amasampula?Imikhiqizo eminingi inikeza amasampula wamahhala wokuhlolwa kwekhwalithi, izindleko zokuthumela kufanele zikhokhelwe amakhasimende.

Ukuhlolwa Kwemboni?Wamukelekile ekucwaningweni kwemboni.Sicela wenze i-aphoyintimenti kusengaphambili.

I-MOQ?Ayikho i-MOQ.I-oda elincane liyamukeleka.

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Amadokhumenti?Ngemuva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njll.

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Isicelo:

I-2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl) i-ethanamine Hydrochloride (CAS: 1053239-39-6) iphakathi kwe-Ramelteon (CAS: 196597- 26-9).Ngokungafani nokwelashwa okuningi kokuqwasha okuqondise ku-GABA (g-aminobutyric acid) receptor complex, u-Ramelteon uyi-agonist ye-melatonin receptor.Ikakhulukazi, inokukhetha okuphezulu kwe-MT1 ne-MT2 subtypes, eye yathinteka ekugcinweni kwezigqi ze-circadian, ngaphezu kwesamukeli se-MT3 esibhekele eminye imisebenzi ye-melatonin.Ukuntuleka kwayo kokuzwana hhayi kuphela kwe-GABA receptor complex kodwa ne-neurotransmitter, dopaminerigic, opiate, kanye ne-benzodiazepine receptors kuphakamisa iphrofayili yokuphepha ethuthukisiwe engenawo amandla okuhlukumeza ezidakamizwa zokulutha eziqondise lezi zamukeli.Kanjalo, i-Ramelteon ayisona isidakamizwa esihleliwe.Ama-metabolites ayisisekelo ahlanganisa i-hydroxylation kanye ne-oxidation ezinhlotsheni ze-carbonyl ezinama-metabolites esibili aphuma ku-glucuronidation.Njengoba i-CYP1A2 iyi-isozyme enkulu ebandakanyeka ku-hepatic metabolism ye-Ramelteon, akufanele ithathwe ngokuhambisana nama-CYP1A2 inhibitors aqinile, njenge-fluvoxamine.Ukusetshenziswa kanyekanye ne-ketoconazole (i-CYP3A4 inhibitor) noma i-fluconazole (i-CYP2C9 inhibitor enamandla) kubangele ukwanda okukhulu kwe-AUC ne-Cmax, kodwa ukuqina kwe-metabolism kanye nokugxila okuguquguqukayo okukhulu kwe-Ramelteon ku-plasma kwavimbela isidingo sokuguqulwa komthamo.Ukufakwa kwephakheji, nokho, kuxwayisa iziguli mayelana nokuphatha ngokubambisana ne-CYP3A4 enamandla kanye ne-CYP2C9 inhibitors.Ngokusekelwe kumphumela wokuhlolwa komtholampilo, umthamo onconyiwe we-Ramelteon ngu-8mg othathwe phakathi nemizuzu engama-30 yokulala.Ngaphezu kokuqapha kokuphatha ngokubambisana ne-CYP inhibitors, akufanele isetshenziswe ezigulini ezinokukhubazeka okukhulu kwe-hepatic.Izehlakalo ezingezinhle, ezibonwe ku-5% weziguli ezifundweni zomtholampilo, kwaba ukuqwasha, isiyezi, isicanucanu, ukukhathala, ikhanda elibuhlungu nokuqwasha.