Rapamycin Sirolimus RAPA CAS 53123-88-9 Assay ≥98.5% API Factory High Purity
Umkhiqizi onokuhlanzeka Okuphezulu kanye Nekhwalithi Ezinzile
Igama Lekhemikhali: Rapamycin;I-Sirolimus;I-RAPA
I-CAS: 53123-88-9
I-Macrolide Immunosuppressive Agent
Ikhwalithi ephezulu ye-API, Ukukhiqiza Kwezentengiso
Igama Lekhemikhali | I-Rapamycin |
Omqondofana | I-Sirolimus;I-RAPA;AY-22989 |
Inombolo ye-CAS | 53123-88-9 |
Inombolo yeCAT | I-RF-API59 |
Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifika Emakhulwini Amakhilogremu |
I-Molecular Formula | I-C51H79NO13 |
Isisindo samangqamuzana | 914.19 |
I-Melting Point | 183.0~185.0℃ |
Ibhrendi | I-Ruifu Chemical |
Into | Imininingwane |
Ukubukeka | I-Crystalline Powder Emhlophe noma Engamhlophe |
Ukuhlonza A | I-IR spectrum ye-potassium bromide yokulungiswa kwesampula ibonisa ubukhulu obungamaza wamaza afanayo nalolo lokulungiselelwa okufanayo kwezinga lereferensi yasendlini. |
Ukuhlonza B | I-spectrum ye-UV ye-95% yokulungiswa kwe-ethanol yesampula ibonisa ubukhulu obungu-267nm, 277nm, 288nm njengalelo lokulungiswa okufanayo kwezinga lereferensi yangaphakathi. |
Ukuhlonza C | Isikhathi sokugcinwa kweziqongo zama-trans-and cis-stereoisomers ku-chromatogram yokulungiswa kokuhlolwa sihambisana naleso esiku-chromatogram yokulungiselelwa okujwayelekile, njengoba kutholwe ku-assay. |
Ukujikeleza kwe-Optical | -147.0°~ -157.0° |
Ukulahlekelwa Ekumisweni | ≤0.50% |
Izinsalela ekushiseni | ≤0.20% |
Izinsimbi Ezisindayo | ≤20ppm |
Ukungcola Ngamunye | ≤1.5% |
Ukungcola Okuphelele | ≤2.0% (ngaphandle kwe-Cis-Stereoisomer ye-Sirolimus) |
Cis-Stereoisomer of Sirolimus | ≤5.0% |
Izincibilikisi Ezisele | |
I-Ethanol | ≤5000ppm |
I-Ethyl Acetate | ≤5000ppm |
I-Cyclohexane | ≤5000ppm |
I-acetone | ≤5000ppm |
I-Diethyl Ether | ≤5000ppm |
Isivivinyo | ≥98.5% (Ibalwe i-trans- ne-cis-stereoisomer ye-sirolimus ngokwesisekelo esinqunyiwe) |
Izinga Lokuhlola | I-Chinese Pharmacopoeia (CP);I-Enterprise Standard |
Ukusetshenziswa | I-Active Pharmaceutical Ingredient (API) |
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, isigubhu seCardboard, 25kg/Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni, umswakama kanye nezinambuzane.
I-Rapamycin (i-Sirolimus; i-AY 22989) iyi-activator ye-autophagy, uhlobo olusha lwe-macrolide immunosuppressive ejenti enemiphumela emihle yokwelapha, ubuthi obuphansi, futhi ayikho i-nephrotoxicity.Ingasetshenziselwa ukugcina ukungatheleleki kwezitho zokufakelwa (ikakhulukazi ekufakweni kwezinso) ukuze kuncishiswe ukwenqatshwa kwe-immunological ngemva kokuhlinzwa kokufakelwa isitho.