I-Remdesivir GS-5734 CAS 1809249-37-3 COVID-19 API Isithombe Esifakiwe Sekhwalithi Ephezulu

I-Remdesivir GS-5734 CAS 1809249-37-3 COVID-19 API Ikhwalithi ephezulu

Incazelo emfushane:

Igama Lekhemikhali: Remdesivir (GS-5734)

I-CAS: 1809249-37-3

Ukubukeka: Okumhlophe kuya Kokumhlophe Okuqinile Okuqinile

Isilinganiso: 98.0%~102.0%

I-Remdesivir yokwelapha i-COVID-19

Ikhwalithi ephezulu ye-API, Ukukhiqiza Kwezentengiso

Inquiry: alvin@ruifuchem.com

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Imikhiqizo Ehlobene

Omaka bomkhiqizo

Incazelo:

Umkhiqizi Wokuhlinzeka Ngempahla Yezohwebo i-Remdesivir kanye Nezixhumanisi Ezihlobene Nekhwalithi Ephezulu
I-Remdesivir CAS 1809249-37-3
2-Ethyl-1-butanol CAS 97-95-0
I-Trimethylsilyl Cyanide CAS 7677-24-9
I-4-Nitrophenol CAS 100-02-7
2-Ethylbutyl ((S)-(perfluorophenoxy)(phenoxy)phosphoryl)-L-alaninate CAS 1911578-98-7
N-[(S)-(4-nitrophenoxy)phenoxyphosphinyl]-L-Alanine 2-ethylbutyl ester CAS 1354823-36-1
(S)-2-Ethylbutyl 2-Aminopropanoate Hydrochloride CAS 946511-97-3
I-Remdesivir Metabolite (GS-441524) CAS 1191237-69-0
I-Remdesivir N-2 I-CAS Emaphakathi 1191237-80-5
2,3,5-Tri-O-benzyl-D-ribonolactone CAS 55094-52-5
7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine CAS 937046-98-5
I-Pyrrolo[1,2-F][1,2,4]Triazin-4-Amine CAS 159326-68-8
4-Amino-7-iodopyrrolo[2,1-f][1,2,4]triazine CAS 1770840-43-1

Chemical Properties:

Igama Lekhemikhali	I-Remdesivir
Omqondofana	GS-5734;2-ethylbutyl ((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano -3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate
Inombolo ye-CAS	1809249-37-3
Inombolo yeCAT	I-RF-API96
Isimo Sesitoko	Esitokweni, Isikali Sokukhiqiza Sifika Emakhulwini Amakhilogremu
I-Molecular Formula	I-C27H35N6O8P
Isisindo samangqamuzana	602.58
Ukuminyana	1.47±0.1 g/cm3
Ibhrendi	I-Ruifu Chemical

Imininingwane:

Into	Imininingwane
Ukubukeka	Impushana Eqinile Emhlophe ukuya Kokumhlophe
Ukuhlonza A	IR: I-spectrum yokumuncwa kwe-infrared yomkhiqizo kufanele ihambisane naleyo yereferensi yento.
Ukuhlonza B	Isikhathi sokugcina se-HPLC sifana nento eyisethenjwa
Ukuzungezisa okuqondile	-19.0° ~ -22.0°
Ukuncibilika	I-Solunle ku-Methanol, Incibilika Kancane ku-Ethanol, Incibilika Kancane ku-Acetonitrile, Ayincibiliki Emanzini
Izinto Ezihlobene
Noma yikuphi Ukungcola Komuntu Ngamunye	≤0.10%
Ukungcola Okuphelele	≤1.0%
I-RD-3.1	≤0.10%
I-RD-C	≤0.10%
I-RD-D	≤0.10%
I-RD-E	≤0.10%
I-RP-Isomer	≤0.10%
I-Nitrophenol	≤0.10%
Izincibilikisi Ezisele
I-Methanol Dichloride	≤6000ppm
I-acetone	≤5000ppm
Isopropyl Utshwala	≤5000ppm
I-acetonitrile	≤410ppm
I-Dichloromethane	≤600ppm
I-Methyl tert Butyl Ether	≤5000ppm
I-Ethyl Acetate	≤5000ppm
I-Tetrahydrofuran	≤720ppm
n-Heptane	≤5000ppm
Isivivinyo	98.0%~102.0% (Ibalwe ngokomisiwe)
Izibalo eziphelele ze-Aerobic
I-Aerobic Amagciwane	≤100cfu/g
Imvubelo nesikhunta	≤10cfu/g
E. Ikhoyili	Okubi
I-Endotoxin yebhaktheriya	≤1.0EU
Izinsimbi Ezisindayo	≤20ppm
Izinga Lokuhlola	I-Enterprise Standard
Ukusetshenziswa	I-API, i-COVID-19

Iphakheji nesitoreji:

Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, isigubhu seCardboard, 25kg/Drum, noma ngokwezidingo zekhasimende.

Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni, umswakama kanye nezinambuzane.

Izinzuzo:

I-FAQ:

Isicelo:

I-Remdesivir (i-CAS 1809249-37-3), ethengiswa ngaphansi kwegama lomkhiqizo i-Veklury, umuthi we-antiviral obanzi owenziwe yinkampani ye-biopharmaceutical Gilead Sciences.Ilawulwa ngomjovo emithanjeni.Ngesikhathi sobhubhane lwe-COVID-19, i-remdesivir yagunyazwa noma yagunyazwa ukusetshenziswa okuphuthumayo ukwelapha i-COVID-19 emazweni acishe abe ngu-50.Imihlahlandlela ebuyekeziwe evela ku-World Health Organization ngoNovemba 2020 ihlanganisa isincomo esinemibandela ngokumelene nokusetshenziswa kwe-Remdesivir ekwelapheni i-COVID-19.I-Remdesivir ekuqaleni yathuthukiswa ukwelapha isifo sokusha kwesibindi kohlobo C, futhi yabe isiphenywa ngesifo segciwane le-Ebola kanye nokutheleleka ngegciwane laseMarburg ngaphambi kokuthi ifundwe njengokwelashwa kwangemva kokutheleleka kwe-COVID-19.Umphumela ovame kakhulu kumavolontiya anempilo ukukhuphuka kwamazinga egazi ama-enzyme esibindi (uphawu lwezinkinga zesibindi).Umthelela oseceleni ovame kakhulu kubantu abane-COVID-19 isicanucanu.Imiphumela engemihle ingase ihlanganise ukuvuvukala kwesibindi kanye nokusabela okuhlobene nokumnika okuhambisana nesicanucanu, umfutho wegazi ophansi, nokujuluka.I-Remdesivir iwumkhiqizo okuhloswe ngawo ukuvumela ukulethwa kwe-intracellular ye-GS-441524 monophosphate kanye ne-biotransformation elandelayo ibe yi-GS-441524 triphosphate, i-ribonucleotide analogue inhibitor ye-viral RNA polymerase.