I-Rivastigmine Tartrate CAS 129101-54-8 Assay 98.0~102.0
I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi ohamba phambili we-Rivastigmine Tartrate (CAS: 129101-54-8) enekhwalithi ephezulu.I-Ruifu Chemical inganikeza ukulethwa komhlaba wonke, intengo encintisanayo, isevisi enhle kakhulu, amanani amancane kanye nenqwaba etholakalayo.Thenga i-Rivastigmine Tartrate,Please contact: alvin@ruifuchem.com
| Igama Lekhemikhali | I-Rivastigmine Tartrate |
| Omqondofana | Exelon;ENA-713;I-Rivastigmine L-Tartrate;I-Rivastigmine Hydrogen Tartrate;I-CS-118;I-S-Rivastigmine Tartrate;3-[(S)-1-(Dimethylamino)ethyl]phenyl N-Ethyl-N-Methylcarbamate L-Tartrate;I-N-Ethyl-N-Methylcarbamic Acid 3-[(S)-1-(Dimethylamino)ethyl]phenyl Ester L-Tartrate |
| Isimo Sesitoko | Ku-Stock, Commercial Production |
| Inombolo ye-CAS | 129101-54-8 |
| I-CAS ehlobene | 123441-03-2 |
| I-Molecular Formula | C14H22N2O2·C4H6O6 |
| Isisindo samangqamuzana | 400.43 g/mol |
| I-Melting Point | 124.0 ukuze 128.0 ℃ |
| Ukuzungezisa Okuthile [a]20/D | +4.0° ukuya +7.0° (C=5, Methanol) |
| Ukuncibilika | I-Soluble ku-Methanol |
| I-COA ne-MSDS | Iyatholakala |
| Umsuka | Shanghai, China |
| Ibhrendi | I-Ruifu Chemical |
| Izinto | Amazinga Wokuhlola | Imiphumela |
| Ukubukeka | I-Crystalline Powder emhlophe ukuya kokumhlophe | Iyahambisana |
| Isivivinyo | 98.0~102.0% (Kusisekelo Esingenamanzi) | 99.8% |
| Amanzi nguKarl Fischer | ≤0.50% | 0.15% |
| Izinsalela ekushiseni | ≤0.10% | 0.07% |
| Izinsimbi Ezisindayo (Pb) | ≤20ppm | <10ppm |
| Phenol Ukungcola | ≤0.30% | <0.30% |
| I-DPTTA | ≤0.15% | <0.15% |
| Noma Ukungcola | ≤0.15% | <0.15% |
| Ukungcola kweCarbamate | ≤0.15% | <0.15% |
| Ukungcola kwe-Ether | ≤0.15% | <0.15% |
| Noma Ikuphi Okunye Ukungcola | ≤0.10% | <0.10% |
| Ukungcola okuphelele | ≤0.50% | <0.50% |
| I-R-Enantiomer | ≤0.30% | <0.30% |
| I-Infrared Spectrum | Ihambisana Nesakhiwo | Iyahambisana |
| 1H NMR Spectrum | Ihambisana Nesakhiwo | Iyahambisana |
| Isiphetho | Umkhiqizo uhloliwe futhi uhambisana ne-USP35 Standard | |
Iphakheji:Ibhodlela eliFluorinated, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina isiqukathi sivalwe ngokuqinile futhi usigcine endaweni epholile, eyomile (2~8℃) nengena umoya omuhle kude nezinto ezingahambelani.Vikela ekukhanyeni nakumswakama.
Ukuthumela:Zilethe emhlabeni wonke ngendiza, yi-FedEx/DHL Express.Nikeza ukulethwa okusheshayo nokuthembekile.
I-Rivastigmine Tartrate
C14H22N2O2·C4H6O6 400.42
I-Ethylmethylcarbamic acid, i-3-[(S)-1-(dimethylamino)ethyl]phenyl ester, (2R,3R) -2,3-dihydroxybutanedioate;
(S) -3--[1-(Dimethylamino) ethyl]phenyl ethylmethylcarbamate, i-hydrogen tartrate [129101-54-8].
I-Rivastigmine 250.34 [123441-03-2].
INCAZELO
I-Rivastigmine Tartrate iqukethe i-NLT 98.0% kanye ne-NMT 102.0% yenani elinelebula elithi C14H22N2O2·C4H6O6, elibalwa ngesisekelo se-anhydrous.
UKUKHOMBA
• A. I-Infrared Absorption <197K>
• B. Isikhathi sokugcina sesiqongo esikhulu sesixazululo Sesampuli sihambisana naleso sesixazululo sokufaneleka Kwesistimu, njengoba sitholwe ekuhlolweni Kokungcola Kwezinto Eziphilayo, Inqubo 2: I-Enantiomeric Purity.
ISIVIVINYO
• Inqubo
Isigcinalwazi: 8.6 mg/mL ye-monobasic ammonium phosphate.Lungisa ngesisombululo se-ammonia sibe yi-pH engu-7.0.
Isigaba seselula: I-Methanol, i-acetonitrile, ne-Buffer (15:15:70)
Isixazululo sokufaneleka kwesistimu: 0.05 mg/mL ngayinye ye-USP Rivastigmine Inhlanganisela Ehlobene A RS kanye ne-USP Rivastigmine Inhlanganisela Ehlobene B RS esigabeni Seselula
Isixazululo esijwayelekile: 0.2 mg/mL ye-USP Rivastigmine Tartrate RS esigabeni Seselula
Isixazululo sesampula: 0.2 mg/mL ye-Rivastigmine Tartrate esigabeni Seselula
Isistimu yeChromatographic
(Bona i-Chromatography <621>, Ukufaneleka Kwesistimu.)
Imodi: LC
Umtshina: UV 215 nm
Ikholomu: 4.6-mm × 25-cm;5-µm ukupakisha L7
Izinga lokugeleza: 1.2 mL/min
Usayizi womjovo: 20 µL
[Qaphela-Izinga lokugeleza lingalungiswa libe ngu-1.5 mL/min, uma kudingeka, ukuze kuzuzwe isikhathi esinconyiwe sokugcina i-rivastigmine cishe emizuzwini eyi-10.]
Ukufaneleka kwesistimu
Amasampula: Isixazululo sokufaneleka kwesistimu nesixazululo Esijwayelekile
Izidingo zokufaneleka
Isixazululo: I-NLT 1.5 phakathi kwenhlanganisela ehlobene ne-rivastigmine A kanye ne-rivastigmine ehlobene ne-compound B, isisombululo sokufaneleka kwesistimu
Ukusebenza kahle kwekholomu: I-NLT 5000 theory plates, isixazululo esijwayelekile
Isici somsila: NMT 3.0, Isixazululo esijwayelekile
Ukuchezuka okujwayelekile okuhlobene: I-NMT 2.0%, Isixazululo esijwayelekile
Ukuhlaziya
Amasampula: Isixazululo esijwayelekile kanye nesixazululo esiyisampula
Bala iphesenti le-C14H22N2O2·C4H6O6 engxenyeni ye-Rivastigmine Tartrate ethathiwe:
Umphumela = (rU/rS) × (CS/CU) × 100
rU = impendulo ephezulu evela kusixazululo Sesampula
rS = impendulo ephezulu evela kusixazululo Esijwayelekile
CS = ukugxila kwesixazululo Esijwayelekile (mg/mL)
I-CU = ukugxila kwesixazululo sesampula (mg/mL)
Imibandela yokwamukela: 98.0% -102.0% kusisekelo se-anhydrous
UKUNGCOLA
Ukungcola Okungaphili
• Insalela Ekuthutheni <281>: NMT 0.1%
• I-Heavy Metals, Indlela II <231>: NMT 20 ppm
Ukungcola Okuphilayo
• Inqubo 1
Isigaba seselula nesixazululo sokufaneleka kwesistimu: Qhubeka njengoba kuqondiswe ku-Assay.
Isixazululo esijwayelekile: 1.0 µg/mL ye-USP Rivastigmine Tartrate RS esigabeni Seselula
Isixazululo sesampula: 1.0 mg/mL ye-Rivastigmine Tartrate esigabeni Seselula
Isistimu yeChromatographic: Qhubeka njengoba kuqondiswe ku-Assay.
(Bona i-Chromatography <621>, Ukufaneleka Kwesistimu.)
Ukufaneleka kwesistimu
Amasampula: Isixazululo sokufaneleka kwesistimu nesixazululo Esijwayelekile
Izidingo zokufaneleka
Isixazululo: I-NLT 1.5 phakathi kwenhlanganisela ehlobene ne-rivastigmine A kanye ne-rivastigmine ehlobene ne-compound B, isisombululo sokufaneleka kwesistimu
Ukuchezuka okujwayelekile okuhlobene: I-NMT 10%, Isixazululo esijwayelekile
Ukuhlaziywa [Qaphela-Isikhathi sokusebenza izikhathi eziyisi-8 isikhathi sokugcina senani eliphakeme le-rivastigmine.]
Amasampula: Isixazululo esijwayelekile kanye nesixazululo esiyisampula
Bala iphesenti lanoma yikuphi ukungcola komuntu ngamunye engxenyeni ye-Rivastigmine Tartrate ethathiwe:
Umphumela = (rU/rS) × (CS/CU) × (1/F) × 100
i-rU = impendulo ephezulu yokungcola ngakunye okuvela kusixazululo Sesampuli
rS = impendulo ephezulu evela kusixazululo Esijwayelekile
CS = ukugxila kwe-USP Rivastigmine Tartrate RS kusixazululo Esijwayelekile (mg/mL)
I-CU = ukuhlushwa kwe-Rivastigmine Tartrate kusixazululo Sesampula (mg/mL)
F = isici sokuphendula esihlobene (bona Ithebula Lokungcola 1)
Imibandela yokwamukela
Ukungcola komuntu ngamunye: Bheka Ithebula Lokungcola 1.
Ukungcola okuphelele: NMT 0.5%
Ithebula Lokungcola 1
| Igama | Isikhathi Sokugcina Esihlobene | Isici Sempendulo Esihlobene | Umbandela Wokwamukela i-NMT % |
| I-Tartrate | 0.18 | - | Unganaki |
| I-Phenol impuritya | 0.28 | 1.6 | 0.3 |
| I-DPTAb | 0.46 | 0.83 | 0.15 |
| Noma ukungcola | 0.57 | 1.2 | 0.15 |
| I-Rivastigmine | 1.0 | 1.0 | - |
| I-Carbamate engcolile | 4.1 | 1.3 | 0.15 |
| Ukungcola kwe-Ether | 6.5 | 1.4 | 0.15 |
| Noma yikuphi okunye ukungcola | - | 1.0 | 0.1 |
a (S) -3-[1-(Dimethylamino)ethyl]phenol.
b (+)-Di-(p-toluoyl)-d-tartaric acid (inhlanganisela ehlobene ne-rivastigmine A).
c (S) -3-[1-(Dimethylamino)ethyl]phenyl dimethylcarbamate (inhlanganisela B ehlobene ne-rivastigmine).
d 3-Nitrophenyl ethyl(methyl)carbamate.
e (S)-N,N-Dimethyl-1-[3-(4-nitrophenoxy)phenyl]ethanamine.
• Inqubo 2: I-Enantiomeric Purity
I-Buffer: Dlulisa u-1.78 g we-dibasic sodium phosphate dihydrate kanye no-1.38 g we-monobasic sodium phosphate kuflask yevolumu ye-1000-mL.Chaza bese uhlanza ngamanzi ngevolumu.Lungisa nge-phosphoric acid ibe yi-pH engu-6.0.
Isigaba seselula: Dlulisa u-20 mL we-acetonitrile no-205 µL we-N,N-dimethyloctylamine ku-1000-mL ye-volumetric flask, futhi uxube nge-Buffer kuvolumu.
Isixazululo esijwayelekile: 0.1 µg/mL ye-USP Rivastigmine Tartrate R-Isomer RS esigabeni Seselula
Isixazululo sokuzwela: 0.05 µg/mL ye-USP Rivastigmine Tartrate R-Isomer RS esigabeni Seselula, isixazululo esijwayelekile
Isixazululo sokufaneleka kwesistimu: 100 µg/mL ye-USP Rivastigmine Tartrate RS kanye no-0.1 µg/mL ye-USP Rivastigmine Tartrate R-Isomer RS esigabeni Seselula
Isixazululo sesampula: 100 µg/mL ye-Rivastigmine Tartrate esigabeni Seselula
Isistimu yeChromatographic
(Bona i-Chromatography <621>, Ukufaneleka Kwesistimu.)
Imodi: LC
Umtshina: UV 200 nm
Ikholomu: 4.0-mm × 10-cm;ukupakisha L41
Izinga lokugeleza: 0.5 mL/min
Usayizi womjovo: 20 µL
Ukufaneleka kwesistimu
Amasampula: Isixazululo esijwayelekile, Isixazululo Sokuzwela, nesixazululo sokufaneleka kwesistimu
Izidingo zokufaneleka
Ukulungiswa: I-NLT 0.8 phakathi kweziqongo ze-enantiomer, Isixazululo sokufaneleka kwesistimu
[Qaphela-I-elution order yi-R-enantiomer, ilandelwa yi-rivastigmine peak, okuyi-S-enantiomer.]
Isilinganiso somsindo wesignali: NLT 10, Isixazululo sokuzwela
Ukuchezuka okujwayelekile okuhlobene: I-NMT 10%, Isixazululo esijwayelekile
Ukuhlaziya
Amasampula: Isixazululo esijwayelekile kanye nesixazululo esiyisampula
Bala iphesenti le-R-enantiomer engxenyeni ye-Rivastigmine Tartrate ethathiwe:
Umphumela = (rU/rS) × (CS/CU) × 100
rU = impendulo ephezulu ye-R-enantiomer evela kusixazululo Sesampuli
rS = impendulo ephezulu ye-R-enantiomer evela kusixazululo Esijwayelekile
CS = ukugxila kwe-R-enantiomer kusixazululo Esijwayelekile (µg/mL)
I-CU = ukuhlushwa kwe-Rivastigmine Tartrate kusixazululo Sesampula (µg/mL)
Imibandela yokwamukela: I-NMT 0.3% ye-R-enantiomer
IZIVIVINYO EZITHILE
• Ukunqunywa kwamanzi, Indlela Ia <921>: NMT 0.5%
IZIDINGO EZENGEZIWE
• Ukupakisha Nokugcina: Londoloza ezitsheni eziqinile, futhi ugcine endaweni eshisa kakhulu.
• I-USP Reference Standards <11>
I-USP Rivastigmine Tartrate RS
I-USP Rivastigmine Inhlanganisela Ehlobene A RS
I-Di-p-toluoyl-d-(+)-tartaric acid monohydrate.
C20H20O9 404.37
I-USP Rivastigmine Inhlanganisela Ehlobene B RS
N,N-Dimethylcarbamic acid-3-[1-(dimethylamino)ethyl]phenyl ester.
I-C13H20N2O2 236.32
I-USP Rivastigmine Tartrate R-Isomer RS
Indlela Yokuthenga?Sicela uxhumaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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Izimakethe Eziyinhloko?Thengisa emakethe yasekhaya, eNyakatho Melika, eYurophu, eNdiya, eKorea, eJapane, e-Australia, njll.
Izinzuzo?Ikhwalithi ephezulu, intengo ethengekayo, izinsizakalo ezichwepheshile nokusekelwa kobuchwepheshe, ukulethwa okusheshayo.
IkhwalithiIsiqiniseko?Isistimu yokulawula ikhwalithi eqinile.Imishini yobuchwepheshe yokuhlaziya ifaka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, NOMA, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njll.
Amasampula?Imikhiqizo eminingi inikeza amasampula wamahhala wokuhlolwa kwekhwalithi, izindleko zokuthumela kufanele zikhokhelwe amakhasimende.
Ukuhlolwa Kwemboni?Wamukelekile ekucwaningweni kwemboni.Sicela wenze i-aphoyintimenti kusengaphambili.
I-MOQ?Ayikho i-MOQ.I-oda elincane liyamukeleka.
Isikhathi sokuthumela? Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe.
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Amadokhumenti?Ngemuva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njll.
Custom Synthesis?Ingahlinzeka ngezinsizakalo zokwenziwa ngokwezifiso ukuze zilingane kangcono nezidingo zakho zocwaningo.
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Omazisi be-UN UN 2811 6.1 / PGII
I-WGK Germany 3
RTECS FA9550000
I-HS Code 29242990
I-Hazard Class 6.1
Ukupakisha Iqembu III
I-Rivastigmine Tartrate (i-CAS: i-129101-54-8) i-tartrate ye-rivastigmine, umuthi wokwelapha isifo se-Alzheimer's.I-Rivastigmine iphuma ku-physostigmine, eyathuthukiswa ngempumelelo okokuqala yiNovartis, eSwitzerland.Igama lokuhweba yi-exelon, futhi i-molecule inesakhiwo se-benzyl carbamate, i-carbamate brain-selective cholinesterase inhibitor, engavimbela i-acetylcholinesterase ne-butyrylcholinesterase ngesikhathi esifanayo, futhi ikhuthaze ukuqhutshwa kwe-cholinergic nerve ngokubambezela ukuwohloka kwe-acetylcholine ekhishwe yi-cholinergic. izinzwa.Ingathuthukisa ukungasebenzi kahle kwengqondo okulamulwa yi-cholinergic, ngaleyo ndlela ithuthukise umphumela wokuqonda weziguli ezinesifo i-Alzheimer's.Amaprotheni e-plasma abopha amandla e-rivastigmine abuthakathaka, kulula ukudlula emgodleni wegazi nobuchopho, futhi anezinga eliphezulu lokukhetha kobuchopho.Ayikwazi ukwenza ngokukhetha kuphela ezindaweni ezisengozini kakhulu ye-cerebral cortex kanye ne-hippocampus, kodwa futhi ivimbela ngokukhethekile ama-subtypes abusayo e-AChE ebuchosheni, okunganciphisa imiphumela emibi ye-cholinergic ngenkathi ikhiqiza imiphumela yokwelapha.I-half-life ye-rivastigmine tartrate emzimbeni ifushane futhi isikhathi sesenzo side.Ngokungafani ne-tacrine, lo mkhiqizo unomphumela onamandla ovimbela i-G1 enzyme ku-hippocampus kanye ne-cortex.Isetshenziswa ngokomtholampilo ukwelapha ukuwohloka komqondo okumaphakathi kuya komaphakathi, okusolwa njengesifo i-Alzheimer's noma i-Alzheimer's.
1. Njenge-acetylcholinesterase inhibitor, i-rivastigmine bicartrate ingathuthukisa umphumela we-succinylcholine muscle relaxant.Ngakho-ke, kufanele kube nenkathi yesikhashana efanelekile yokuyeka ukuthatha lo mkhiqizo ngaphambi kwe-anesthesia.Lo mkhiqizo kufanele uhlanganiswe namanye amalungiselelo e-cholinergic noma i-anticholinergic, futhi kufanele kuqashelwe (bona [Ukusebenzelana Kwezidakamizwa]).
2. Ngenxa yemiphumela yawo yezemithi, ama-cholinesterase inhibitors angase abe nemiphumela yokucindezeleka kwenzwa ye-vagus ekushayeni kwenhliziyo.Njengezinye izidakamizwa ze-cholinergic, ukuqapha kufanele kusetshenziswe lapho kunikezwa iziguli ezine-sinus syndrome egulayo noma enye i-heart block (bheka Ukusabela Okubi).
3. I-Cholinergic nerve excitement ingabangela ukwanda kwe-gastric acid secretion.Nakuba kungekho bufakazi bokuwohloka okuphawulekayo kwezimpawu ezihambisanayo obutholakala ngesikhathi sokuhlolwa komtholampilo, iziguli ezisengozini enkulu yokuba nesilonda esiswini, njengalezo ezinomlando wesifo sezilonda noma ezithola ukwelashwa okuhambisanayo nezidakamizwa ezingezona ukuvuvukala, kufanele isetshenziswe ngokuqapha.
4. Njengamanye ama-cholinesterase inhibitors, iziguli ezinomlando we-asthma noma esinye isifo se-pulmonary obstructive kufanele zisetshenziswe ngokuqapha.
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