(S)-3-Aminoquinuclidine Dihydrochloride CAS 119904-90-4 Ukuhlanzeka ≥99.0% ee≥99.0% Palonosetron Hydrochloride Intermediate
I-Commercial Supply Palonosetron Hydrochloride kanye Nezixhumanisi Ezihlobene:
(S)-1,2,3,4-Tetrahydro-1-Naphthoic Acid CAS: 85977-52-2
(R)-1,2,3,4-Tetrahedro-1-Naphthoic Acid CAS: 23357-47-3
(S)-3-Aminoquinuclidine Dihydrochloride CAS: 119904-90-4
I-3-Quinuclidinone Hydrochloride CAS: 1193-65-3
I-1-Naphthoic Acid CAS: 86-55-5
I-Palonosetron Hydrochloride CAS: 135729-62-3 API
| Igama Lekhemikhali | (S) -3-Aminoquinuclidine Dihydrochloride |
| Omqondofana | (S)-(-)-3-Aminoquinuclidine 2 HCL |
| Inombolo ye-CAS | 119904-90-4 |
| Inombolo yeCAT | I-RF-CC112 |
| Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani |
| I-Molecular Formula | I-C7H16Cl2N2 |
| Isisindo samangqamuzana | 199.12 |
| Ukuminyana | 1.24g/cm3 |
| I-Melting Point | 260℃ |
| Iphuzu elibilayo | 470.4℃ ku-760mmHg |
| Ukuncibilika Emanzini | Encibilikayo |
| Isimo Sokuthumela | Kuthunyelwe Ngaphansi Kwezinga Lokushisa Le-Ambient |
| Ibhrendi | I-Ruifu Chemical |
| Into | Imininingwane |
| Ukubukeka | I-Crystalline Powder Emhlophe Kuya Kuphuzi Ephuzi |
| IR | I-Absorption Spectra Ihambisana Nereferensi |
| Ukusabela kwe-Chloride | Ukusabela Okuhle |
| Ubumsulwa (HPLC) | ≥98.0% |
| Ukulahlekelwa Ekumisweni | ≤0.50% |
| Ukuzungezisa Okuqondile [α]D20 | -22.0°~ -26.0° (C=1, H2O) |
| Izinsimbi Ezisindayo | ≤20ppm |
| Isitoreji | 5-8℃ Ukungangeni moya |
| Izinga Lokuhlola | I-Enterprise Standard |
| Ukusetshenziswa | I-Palonosetron Hydrochloride (CAS: 135729-62-3) Abaphakathi |
(S)-3-Aminoquinuclidine Dihydrochloride (CAS: 119904-90-4) Umzila Wokwenziwa
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, I-Cardboard Drum, 25kg/Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni, umswakama kanye nezinambuzane.
I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi oholayo nomnikezeli we-(S)-3-Aminoquinuclidine Dihydrochloride (CAS: 2133-40-6) enekhwalithi ephezulu.Kuyinto emaphakathi yemithi ngokuvamile ekuhlanganiseni kwePalonosetron Hydrochloride (CAS: 135729-62-3).
I-Palonosetron Hydrochloride (CAS: 135729-62-3) iyisidakamizwa sokuvimbela isicanucanu nokuhlanza, okuwuhlobo olusha olukhetha kakhulu, oluhambisana kakhulu ne-5-HT3 receptor antagonist engavimba isikhungo sokuhlanza se-reflex neurons presynaptic 5-HT.Ukujabula kwesamukeli kuthinta ngokuqondile isimiso sezinzwa esimaphakathi ku-5-HT.Injabulo ye-impulse receptor ekhiqizwa indima ye-vagal afferent nerve ngemva kwendawo, ivimba iziphetho ze-vagus nerve emathunjini, ivimbela amasignali ku-5-HT.I-receptor trigger zone inganciphisa izehlakalo zokucanuzela kwenhliziyo nokuhlanza.Central Clinically yokwelashwa kwe-acute emetogenic chemotherapy ebangela ukubambezeleka kwesicanucanu nokuhlanza.Ngenxa yomphumela wayo ophezulu wokwelapha, umphumela omncane ongathandeki, impilo ende yesigamu (cishe 40 h), umthamo omncane, nokunye, kuye kwakhanga ukunaka okukhulu.Nge-1,2,3,4-tetrahydro-1-naphthoic acid njengento yokuqala, ukuhlukaniswa, ukuchithwa, ukunciphisa, i-cyclization, usawoti we-palonosetron hydrochloride granisetron.Ucwaningo lwezokwelapha lubonise ukuthi i-palonosetron ingasetshenziswa ngokuphepha ne-corticosteroids, ama-analgesics, ama-antiemetics, ama-antispasmodics kanye nezidakamizwa ezilwa ne-anticholinergic njengezinto zokuqala, ukuhlukaniswa, ukukhishwa, ukunciphisa, i-cyclization, usawoti we-palonosetron hydrochloride granisetron.
