I-Sitagliptin Phosphate Monohydrate CAS 654671-77-9 Purity >99.0% (HPLC) API Factory High Quality

Incazelo emfushane:

Igama Lekhemikhali: I-Sitagliptin Phosphate Monohydrate

I-CAS: 654671-77-9

Ubumsulwa: >99.0% (HPLC on the omisiwe)

Ukubukeka: I-Crystalline Powder Emhlophe ukuya Kokumhlophe

Ukuze ekwelapheni uhlobo II sikashukela mellitus

Ikhwalithi ephezulu ye-API, Ukukhiqiza Kwezentengiso

E-Mail: alvin@ruifuchem.com

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Imikhiqizo Ehlobene

Omaka bomkhiqizo

Incazelo:

Thola Izimo Ezihlobene Ne-Sitagliptin Phosphate Monohydrate:
I-Sitagliptin API CAS 486460-32-6
I-Sitagliptin Phosphate Monohydrate API CAS 654671-77-9
2,4,5-Trifluorophenylacetic Acid CAS 209995-38-0
I-Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid CAS 486460-00-8
I-Sitagliptin Triazole Hydrochloride CAS 762240-92-6
I-Sitagliptin Phosphate Monohydrate Intermediate CAS 486460-21-3

Chemical Properties:

Igama Lekhemikhali	I-Sitagliptin Phosphate Monohydrate
Omqondofana	(R) -3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4- (2,4,5-trifluorophenyl)butan-1-one phosphate monohydrate
Inombolo ye-CAS	654671-77-9
Isimo Sesitoko	Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani
I-Molecular Formula	I-C16H20F6N5O6P
Isisindo samangqamuzana	523.3240802
I-Melting Point	202.0~204.0℃
Ukuncibilika kwamanzi	Incibilika Emanzini
Ukuzungezisa okuqondile	-18.0°~-23.0° (C=1, Amanzi)
Ibhrendi	I-Ruifu Chemical

Imininingwane:

Into	Imininingwane
Ukubukeka	I-Crystalline Powder emhlophe ukuya kokumhlophe
Ukuhlonza nge-HPLC	Isikhathi sokugcinwa kwesampula sihambisana nezinga lokubhekisela
I-IR-Infrared Spectrum	I-IR Absorption Spectrum yesampula izovumelana naleyo ye-spectrum evamile
I-Phosphate	Iyahambisana
Ukuhlanzeka / Indlela Yokuhlaziya	>99.0% (HPLC on the dry basis)
Okuqukethwe kwamanzi (KF)	3.3%~4.4%
Izinsalela ekushiseni	≤0.20%
I-Sulfate	≤0.02%
I-Chloride	≤0.05%
Ukungcola KweChiral	<0.50%
Izinto Ezihlobene
Ukungcola Okukodwa	<0.50%
Ukungcola Okuphelele	<1.0%
I-Ethyl Acetate	<0.50%
Izinsimbi Ezisindayo	<20ppm
Izinga Lokuhlola	I-Enterprise Standard
Ukusetshenziswa	Pharmaceutical Intermediates

Iphakheji nesitoreji:

Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.

Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni nakumswakama.

Izinzuzo:

I-FAQ:

Isicelo:

I-Sitagliptin Phosphate Monohydrate (CAS: 654671-77-9), umuthi omusha wokwelapha uhlobo 2 sikashukela.Ngo-Agasti 2009, umuthi wagunyazwa yi-European Union njengomuthi womugqa wokuqala wokwelapha isifo sikashukela sohlobo 2.I-Sitagliptin Phosphate iyi-inhibitor yokuqala egunyazwe yi-FDA-dipeptidyl peptidase-IV ukuba isetshenziselwe ukwelapha uhlobo 2 sikashukela kuze kube manje, ngaphansi kwegama lokuhweba elithi Januvia.I-Dipeptidylpeptidase Ⅳ (DPP-Ⅳ) yehlisa isithunzi ngokushesha nangempumelelo i-GLP-1, i-GLP-1, eyisikhuthazi esisebenza kahle kakhulu sokukhiqizwa kwe-insulin nokuphuma kwayo, amazinga e-insulin, ngaleyo ndlela kwehle futhi kugcinwe amazinga kashukela egazini ezigulini ezinesifo sikashukela.Njengamanje, imithi isiqinisekisile ukuthi i-DPP-IV inhibitor iwuhlobo olusha lwesidakamizwa esilwa nesifo sikashukela, futhi imiphumela yomtholampilo ibonisa ukuthi izidakamizwa zinomphumela omuhle we-hypoglycemic.Ngenxa yokuthi i-GLP-1 idlala indima encike ku-glucose ekukhuthazeni ukukhiqizwa nokukhiqizwa kwe-insulin, imiphumela emibi evamile efana ne-hypoglycemia nesisindo esibangelwa ukusetshenziswa kwezidakamizwa ze-antidiabetic ayenzeki.